{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T01:03:43Z","timestamp":1782867823813,"version":"3.54.5"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold>The full breastfeeding may lead to insufficient milk intake of newborns and increase the rate of body weight loss (BWL). Severe BWL was generally believed as a cause of significant hyperbilirubinemia in newborn babies. The study aimed to investigate the effect if early supplemental feeding in newborns with birth weight loss at the first 3 days after birth could decrease the rate of hyperbilirubinemia 72 h of birth.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold>A total of 395 neonates with gestational age &amp;gt;37 weeks and birth body weight &amp;gt;2500g were prospectively collected between 2016 and 2018. We analyzed 280 neonates with BWL rate reaching the predictive value (4.5%, 7.5%, and 8% on the first, second, third day after birth, respectively) for subsequent hyperbilirubinemia after 72 hours after birth. The enrolled cases were divided into four subgroups as interventional consecutive milk supplement for 0, 1, 2, and 3 days after birth for further analysis<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold>For newborns with BWL reaching the predictive value on the first day after birth, the serum bilirubin levels were lower in the experimental group than those in the non-involved control group (<jats:italic>p<\/jats:italic>&amp;lt; 0.05). For newborns with three consecutive days of interventional milk supplementation, the serum bilirubin levels at the 72 h after birth showed the lowest levels compared with the other sub-groups with two consecutive days and one consecutive day of interventional milk supplementation (<jats:italic>p<\/jats:italic>&amp;lt; 0.05). Moreover, there was a significantly decreasing trend in the consecutive days of interventional milk supplementation (<jats:italic>p<\/jats:italic>&amp;lt; 0.05).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold>Newborns with BWL over 4.5% on the first day after birth receiving early intervention milk supplementation could significantly reduce serum bilirubin levels at the<\/jats:p><jats:p>72 h after birth. The more days of consecutive milk supplementation after birth may lead to the lower the 72 h serum bilirubin levels. It is recommended to early and consecutive milk supplementation after birth to be an effective way in reducing serum bilirubin levels.<\/jats:p>","DOI":"10.3389\/fped.2021.625536","type":"journal-article","created":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T04:24:06Z","timestamp":1622003046000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Early Supplemental Formula Intervention on Body Weight and Hyperbilirubinemia in Neonates During 72 h After Birth"],"prefix":"10.3389","volume":"9","author":[{"given":"Lu-Lu","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Pei","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Nein-Chen","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen Shei-Dei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.pedneo.2011.11.008","article-title":"Weight loss percentage prediction of subsequent neonatal hyperbilirubinemia in exclusively breastfed neonates","volume":"53","author":"Chang","year":"2012","journal-title":"Pediatr Neonatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"31","DOI":"10.7098\/CN.200806.0031","article-title":"The impact of breast-feeding on early neonatal jaundice","volume":"15","author":"Lin","year":"2008","journal-title":"Clin Neonatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/1471-2431-13-145","article-title":"Bodyweight loss in predicting neonatal hyperbilirubinemia 72 hours after birth in term newborn infants","volume":"13","author":"Yang","year":"2013","journal-title":"BMC Pediatr."},{"key":"B4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1542\/peds.78.5.837","article-title":"Normal serum bilirubin levels in the newborn and the effect of breast-feeding","volume":"78","author":"Maisels","year":"1986","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000243979","article-title":"Unconjugated and conjugated bilirubin pigments during perinatal development. 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