{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T05:28:20Z","timestamp":1770269300427,"version":"3.49.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T00:00:00Z","timestamp":1620086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Purpose:<\/jats:bold> In order to compensate for the early intrauterine growth restriction, small-for-gestational age (SGA) infants have \u201ccatch-up growth\u201d after birth. Increased caloric intake has been suggested for SGA infants conventionally. It is important to determine if the early growth rate of body mass index (BMI) is associated with risk of persistent obesity later in life. In this longitudinal cohort study, we assessed the BMI of a large cohort of children who were SGA at birth to determine their risk of persistent obesity at school age (6\u20137 years) due to excessive weight gain in the first 3 years of life.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We collected the height and weight data of 23,871 SGA babies. A polynomial function was used to fit the BMI-for-age z-score (BAZ) values of 0\u20136 years old SGA children and interpolate their growth trajectory. In addition, we screened out 6,959 children from 23,871 children to further evaluate the dynamic changes of early childhood BMI. We divided the school-age children into groups as non-obese (BAZ &amp;lt; 2) and obese (BAZ &amp;gt; 2), and determined the association between changes in BMI and school-age obesity.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> From the perspective of BMI distribution, the interpolated growth trajectory indicated that SGA children reaching overweight status or developing obesity by 3 years of age, continued to have obesity until school age (R<jats:sup>2<\/jats:sup>, 0.65; R<jats:sup>2<\/jats:sup>, 0.21). The retrospective analysis showed that children who were overweight and had obesity during school age had a high BMI from early age. By analyzing the changes in early BMI, we found that the fastest growth of SGA children occurred in the early infancy before 6 months and they continued to grow rapidly for a period of time. Interestingly, former SGA children who maintained a near overweight (1 &amp;lt; BAZ &amp;lt; 2) status before the age of 2 maintained an appropriate growth rate and usually did not develop obesity.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> A rapid increase in BMI during early infancy in former SGA newborns leads to a persistent risk of obesity. The energy intake of SGA infants should appropriately meet the infants' growth needs and early BMI changes should be closely monitored for an optimal integrated management.<\/jats:p>","DOI":"10.3389\/fped.2021.625853","type":"journal-article","created":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T04:15:28Z","timestamp":1620101728000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Rapid BMI Increases and Persistent Obesity in Small-for-Gestational-Age 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