{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:52:37Z","timestamp":1788357157598,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Modern surgical techniques and scientific advancements have made liver transplant (LT) in infants feasible. However, there are only a small number of studies examining the short- as well as long-term outcomes of LT in this vulnerable subset of children.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Comprehensive searches were done systematically through the PubMed, Scopus, and Google scholar databases. Studies that were retrospective record based or adopted a cohort approach and reported either patient survival rates or graft survival rates or complications of LT in infants were included in the meta-analysis. Statistical analysis was done using STATA version 13.0.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 22 studies were included in the meta-analysis. The overall pooled patient survival rate at 1 year, &amp;gt;1\u20135 years, and &amp;gt;5 years post-transplantation was 85% (95% CI: 78-\u221292%), 71% (95% CI: 59\u201383%), and 80% (95% CI: 69\u201391%), respectively. The overall pooled graft survival rate at 1 year, &amp;gt;1\u20135 years, and &amp;gt;5 years post-transplantation was 72% (95% CI: 68\u201376%), 62% (95% CI: 46\u201378%), and 71% (95% CI: 56\u201386%), respectively. The overall pooled rate for vascular complications, need for re-transplantation, biliary complications, and infection\/sepsis was 12% (95% CI: 10\u201315%), 16% (95% CI: 12\u201320%), 15% (95% CI: 9\u201321%), and 50% (95% CI: 38\u201361%), respectively.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The current meta-analysis showed modest patient and graft survival rates for infant liver transplantation. However, the complication rates related to infection\/sepsis were high. More comprehensive evidence is required from studies with larger sample sizes and a longer duration of follow-up.<\/jats:p>","DOI":"10.3389\/fped.2021.628771","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T04:29:29Z","timestamp":1619670569000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Survival and Complication of Liver Transplantation in Infants: A Systematic Review and Meta-Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Yifu","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongji","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.5754\/hge12956","article-title":"Can primary LDLT be the alternative first line treatment for infant patients with biliary atresia?","volume":"60","author":"Wang","year":"2013","journal-title":"Hepatogastroenterology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"11062","DOI":"10.3748\/wjg.v20.i32.11062","article-title":"Beyond the Pediatric end-stage liver disease system: solutions for infants with biliary atresia requiring liver transplant","volume":"20","author":"Tessier","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm649","article-title":"Indications for pediatric liver transplantation. 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