{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:38:38Z","timestamp":1761514718790,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T00:00:00Z","timestamp":1612915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>During the COVID pandemic, a surge in pediatric Type 1 Diabetes Mellitus (T1DM) cases appears to be occurring, potentially due to the presence of autoantibody-induced immune dysregulation triggered by COVID-19. We describe one such case in a previously healthy 7-year-old with asymptomatic COVID-19 presenting with a high nasopharyngeal SARS CoV-2 virus load, detectable COVID-19 IgG antibodies, diabetic keto-acidosis and islet cell autoantibodies. COVID-19 is not a trivial disease in children and adolescents and can lead to lifelong sequelae such as T1DM. Raising awareness about a possible association between COVID-19 and T1DM in children is critical.<\/jats:p>","DOI":"10.3389\/fped.2021.628810","type":"journal-article","created":{"date-parts":[[2021,2,10]],"date-time":"2021-02-10T14:31:14Z","timestamp":1612967474000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Case Report: Insulin-Dependent Diabetes Mellitus and Diabetic Keto-Acidosis in a Child With COVID-19"],"prefix":"10.3389","volume":"9","author":[{"given":"Karin","family":"Nielsen-Saines","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Martinez","family":"Olivera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel","family":"Martin-Blais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonca","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2020.13445","article-title":"Ketoacidosis in children and adolescents with newly diagnosed type 1 diabetes during the COVID-19 pandemic in Germany","volume":"324","author":"Kamrath","year":"2020","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.2337\/dc20-1551","article-title":"New-onset Type 1 diabetes in children during COVID-19: multicenter regional findings in the U.K","volume":"43","author":"Unsworth","year":"2020","journal-title":"Diab Care."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1007\/s00125-017-4365-5","article-title":"Respiratory infections are temporally associated with initiation of type 1 diabetes autoimmunity: the TEDDY study","volume":"60","author":"L\u00f6nnrot","year":"2017","journal-title":"Diabetologia."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e172","DOI":"10.2337\/dc20-1633","article-title":"Did the COVID-19 lockdown affect the incidence of pediatric type 1 diabetes in Germany?","volume":"43","author":"Tittel","year":"2020","journal-title":"Diabetes Care."},{"key":"B5","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1056\/NEJMc2018688","article-title":"New-onset diabetes in Covid-19","volume":"383","author":"Rubino","year":"2020","journal-title":"N Engl J Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1038\/s42255-020-00281-8","article-title":"Autoantibody-negative insulin-dependent diabetes mellitus after SARS-CoV-2 infection: a case report","volume":"2","author":"Hollstein","year":"2020","journal-title":"Nat Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1111\/pedi.12659","article-title":"A plateau in new onset type 1 diabetes: Incidence of pediatric diabetes in the United States Military Health System","volume":"19","author":"Rush","year":"2018","journal-title":"Pediatr Diabetes."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.15585\/mmwr.mm6932e3","article-title":"Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19 - 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