{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:00:33Z","timestamp":1792645233968,"version":"4.5.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> There is limited information on therapeutic benefits and tube-related complications of pediatric nasoenteric (NE) tube feeding. We viewed, from different clinical aspects, NE tube feeding in children who are under intolerable conditions.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A 10-years retrospective study enrolled 77 pediatric patients who underwent an endoscopic-guided placement of the NE tube for enteral nutrition. The evaluated data, including growth parameters, feeding volume, parenteral nutrition (PN) dependence, and nutritional markers [serum hemoglobin (Hb) and albumin] before and after NE tube feeding were compared. Tube-related complications and major adverse events were also recorded.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 77 patients (including 50 males) underwent 176 endoscopic-guided placements of the NE tube with an average duration of 133.7 (6.0\u20131,847.3) days. The gastroesophageal reflux disease-related symptoms (vomiting, desaturations, and aspiration pneumonia) improved in 71.4% of patients. Feeding volume increased significantly after intervention, especially in patients with delayed gastric emptying, from 144.8 \u00b1 28.5 to 1,103.1 \u00b1 524.7 ml\/days (<jats:italic>p<\/jats:italic> &amp;lt; 0.001). Weaning from PN was successfully achieved in 84.3% of patients with an average of 9.33 \u00b1 7.30 days. About 16 patients (20.8%) were subsequently highly compatible with oral feeding after NE tube placement for an average of 24.7 \u00b1 14.1 days. Patients either without neurologic dysfunction or with no ventilator-dependent status had a higher chance of shifting to oral feeding. Weight-for-age <jats:italic>z<\/jats:italic>-scores increased by 0.15 \u00b1 1.33 after NE tube intervention. One NE tube-related adverse event, which caused bowel perforation at 6 days post-insertion, was recorded. No direct tube-related mortality was observed.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Endoscopic-guided NE tube placement is a relatively safe, non-invasive procedure for pediatric patients who require enteral nutrition. Feeding <jats:italic>via<\/jats:italic> NE tube showed beneficial effects such as improvement in symptoms, PN weaning, and maintenance of body growth without major tube-related complications.<\/jats:p>","DOI":"10.3389\/fped.2021.646395","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T05:07:03Z","timestamp":1616044023000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Therapeutic Efficacy of Nasoenteric Tube Feeding in Children Needing Enteral Nutrition"],"prefix":"10.3389","volume":"9","author":[{"given":"Mi-Chi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsun-Chin","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai-Jui","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Wei","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/MPG.0b013e3181d336d2","article-title":"Practical approach to paediatric enteral nutrition: a comment by the ESPGHAN committee on nutrition","volume":"51","author":"Braegger","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"B2","first-page":"109","article-title":"Enteral nutrition and mucosal immunity: implications for feeding strategies in surgery and trauma","volume":"47","author":"Sigalet","year":"2004","journal-title":"Can J Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1097\/MOP.0000000000000666","article-title":"Feeding tubes in children","volume":"30","author":"Volpe","year":"2018","journal-title":"Curr Opin Pediatr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.gtc.2017.09.003","article-title":"Enteral access and associated complications","volume":"47","author":"DeLegge","year":"2018","journal-title":"Gastroenterol Clin North Am."},{"key":"B5","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1007\/s004649900390","article-title":"Prospective evaluation of a new through-the-scope nasoduodenal enteral feeding tube","volume":"11","author":"Damore","year":"1997","journal-title":"Surg Endosc."},{"key":"B6","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1097\/MPG.0000000000002379","article-title":"The use of jejunal tube feeding in children: a position paper by the gastroenterology and nutrition committees of the european society for paediatric gastroenterology, hepatology, and nutrition 2019","volume":"69","author":"Broekaert","year":"2019","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1097\/MPG.0000000000001646","article-title":"European society for paediatric gastroenterology, hepatology and nutrition guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with neurological impairment","volume":"65","author":"Romano","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1007\/s00431-018-3229-4","article-title":"A review of feeding intolerance in critically ill children","volume":"177","author":"Tume","year":"2018","journal-title":"Eur J Pediatr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1136\/pmj.78.918.198","article-title":"Enteral feeding. 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