{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:50Z","timestamp":1753892090926,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T00:00:00Z","timestamp":1623110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002380","name":"Hanyang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002380","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background and Objectives:<\/jats:bold> Anaphylaxis, a severe allergic disease, can be triggered by various causes. This study investigated the association between allergic sensitization and anaphylactic symptoms and the severity of anaphylaxis in children.<\/jats:p><jats:p><jats:bold>Patients and Methods:<\/jats:bold> A retrospective review of 107 pediatric patients with anaphylaxis was performed between January 1, 2015, and December 31, 2017; 74 patients underwent allergen testing for specific immunoglobulin E. Allergic sensitizations and associations with anaphylactic symptoms and severity were investigated.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Overall, 64 (86.5%) patients were sensitized to food or inhalant allergens. In children under 2 years of age, 90.5% were sensitized to food (<jats:italic>P<\/jats:italic> = 0.001); in those over 6 years of age, 84.6% were sensitized to inhalant allergens (<jats:italic>P<\/jats:italic> = 0.001). Milk sensitization was significantly associated with severe anaphylaxis (<jats:italic>P<\/jats:italic> = 0.036). The following symptoms showed significant associations with certain allergen sensitizations: facial edema with food; wheezing with milk; dyspnea with mite, etc. Certain allergen sensitizations presenting as risk factors for anaphylactic symptoms: wheat (adjusted odds ratio [aOR] = 4.644, <jats:italic>P<\/jats:italic> = 0.044) and nuts (aOR=3.614, <jats:italic>P<\/jats:italic> = 0.041) for wheezing, nuts (aOR=5.201, <jats:italic>P<\/jats:italic> = 0.026) for dyspnea, and milk (aOR=4.712, <jats:italic>P<\/jats:italic> = 0.048) for vomiting.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The allergen sensitization status differed according to the age of the children experiencing anaphylaxis. The severity, symptoms, and signs of anaphylaxis differed depending on the allergen sensitization status.<\/jats:p>","DOI":"10.3389\/fped.2021.651375","type":"journal-article","created":{"date-parts":[[2021,6,8]],"date-time":"2021-06-08T05:03:20Z","timestamp":1623128600000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Allergen Sensitization and Anaphylaxis in Patients Visiting a Pediatric Emergency Department"],"prefix":"10.3389","volume":"9","author":[{"given":"Won Seok","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily Myung-Jin","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Yong","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung Suk","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.pcl.2019.06.005","article-title":"Anaphylaxis in children and adolescents","volume":"66","author":"Poowuttikul","year":"2019","journal-title":"Pediatr Clin North Am."},{"key":"B2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.jaip.2016.08.013","article-title":"Increasing emergency department visits for anaphylaxis, 2005-2014","volume":"5","author":"Motosue","year":"2017","journal-title":"J Allergy Clin Immunol Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.jaci.2013.08.016","article-title":"Anaphylaxis in America: the prevalence and characteristics of anaphylaxis in the United States","volume":"133","author":"Wood","year":"2014","journal-title":"J Allergy Clin Immunol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2014104","DOI":"10.1155\/2020\/2014104","article-title":"Characteristics and treatment of anaphylaxis in children visiting a pediatric emergency department in Korea","volume":"2020","author":"Lee","year":"2020","journal-title":"Biomed Res Int."},{"key":"B5","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/j.jaci.2004.04.029","article-title":"Clinical features and severity grading of anaphylaxis","volume":"114","author":"Brown","year":"2004","journal-title":"J Allergy Clin Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1398-9995.2008.01719.x","article-title":"Paediatric anaphylaxis: a 5 year retrospective review","volume":"63","author":"de Silva","year":"2008","journal-title":"Allergy."},{"key":"B7","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3238\/arztebl.2014.0367","article-title":"Triggers and treatment of anaphylaxis: an analysis of 4,000 cases from Germany, Austria and Switzerland","volume":"111","author":"Worm","year":"2014","journal-title":"Dtsch Arztebl Int."},{"key":"B8","doi-asserted-by":"publisher","first-page":"E2787","DOI":"10.3390\/ijerph17082787","article-title":"Clinical manifestations and causes of anaphylaxis. 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