{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T22:31:47Z","timestamp":1787697107524,"version":"build-2784847793"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To determine the risk factors of persistent pulmonary hypertension of the newborn using a meta-analysis method and provide a reference for its clinical prevention and treatment.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> A meta-analysis was performed by searching the PubMed, Embase, Cochrane Library, China Biology Medicine Disc, Wanfang, and Chinese VIP journal databases, as well as the China National Knowledge Infrastructure.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 22 references were included in the meta-analysis; the cumulative medical records comprised 7,937 cases, and 2,613,072 control cases were included. A total of 12 related risk factors were included (7 were associated with pregnant women and 5 were associated with newborns).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Among the 12 associated risk factors included, the three most important and their combined odds ratio values and 95% CI were as follows: (1) pregnant women smoking, 4.85 (1.98\u201311.9) during pregnancy; (2) gestational weeks &amp;lt;37, 4.34 (1.64\u201311.5); (3) perinatal asphyxia, 3.9 (2.87\u20135.31).<\/jats:p>","DOI":"10.3389\/fped.2021.659137","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T05:43:18Z","timestamp":1635486198000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["A Meta-Analysis of the Risk Factors of Persistent Pulmonary Hypertension in 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