{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:01:51Z","timestamp":1783112511056,"version":"3.54.6"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T00:00:00Z","timestamp":1627344000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Recurrent wheezing is a common clinical manifestation in childhood, and respiratory syncytial virus infection is a well-known risk factor. However, the genetic background favoring the development of recurrent wheezing is not fully understood. A possible role of macrophage receptor with collagenous gene (MARCO) polymorphism has been recently proposed.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> To investigate a correlation between MARCO rs1318645 polymorphisms and susceptibility to recurrent wheezing during childhood.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We prospectively recruited 116 infants, of which 58 with respiratory syncytial virus bronchiolitis and 58 controls hospitalized at Regina Margherita Children's Hospital, Turin, Italy, between November 2014 and April 2015. All subjects were investigated for MARCO rs1318645 polymorphisms in the first period of life. Genotyping of rs1318645 was carried out by TaqMan mismatch amplification mutation assay real-time polymerase chain reaction procedure. Subjects were then enrolled in a 5-year follow-up study to monitor the occurrence of wheezing and respiratory infections.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The analysis of MARCO rs1318645 of allelic frequencies shows an increasingly significant risk to develop recurrent infection (<jats:italic>p<\/jats:italic> = 0.00065) and recurrent wheezing (<jats:italic>p<\/jats:italic> = 0.000084) with a wild-type C allele compared with a G allele. No correlation was found between wheezing and past respiratory syncytial virus infection (<jats:italic>p<\/jats:italic> = 0.057) and for a history of atopy in the family (<jats:italic>p<\/jats:italic> = 0.859).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our finding showed that subjects with C allelic MARCO rs1318645 polymorphism are at higher risk for recurrent infection and wheezing episodes during the first 5 years of life. Future studies of genetic associations should also consider other types of polymorphisms.<\/jats:p>","DOI":"10.3389\/fped.2021.666423","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T07:11:47Z","timestamp":1627369907000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Macrophage Receptor With Collagenous Structure Polymorphism and Recurrent Respiratory Infections and Wheezing During Infancy: A 5-Years Follow-Up Study"],"prefix":"10.3389","volume":"9","author":[{"given":"Francesco","family":"Savino","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Pellegrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Dapr\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Calvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Alliaudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Montanari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Galliano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Bergallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.5588\/ijtld.14.0170","article-title":"Global burden of asthma among children","volume":"18","author":"Asher","year":"2014","journal-title":"Int J Tuberc Lung Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1136\/thx.2009.121582","article-title":"Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life","volume":"65","author":"Sigurs","year":"2010","journal-title":"Thorax."},{"key":"B3","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S2213-2600(18)30055-9","article-title":"Respiratory syncytial virus prevention and asthma in healthy preterm infants: a randomised controlled trial","volume":"6","author":"Scheltema","year":"2018","journal-title":"Lancet Respir Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e013034","DOI":"10.1136\/bmjopen-2016-013034","article-title":"Association between rhinovirus wheezing illness and the development of childhood asthma: a meta-analysis","volume":"7","author":"Liu","year":"2017","journal-title":"BMJ Open."},{"key":"B5","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1128\/CMR.00017-08","article-title":"Human genetic factors and respiratory syncytial virus disease severity","volume":"21","author":"Miyairi","year":"2008","journal-title":"Clin Microbiol Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"178","DOI":"10.3390\/cells4020178","article-title":"Scavenger receptor structure and function in health and disease","volume":"4","author":"Zani","year":"2015","journal-title":"Cells."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.23736\/S1120-4826.19.02567-9","article-title":"TaqMAMA assay polymerase chain reaction real time for allelic discrimination of Macrophage receptor with collagenous structure rs1318645 polymorphism","volume":"32","author":"Galliano","year":"2020","journal-title":"Minerva Biotecnol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S2213-2600(18)30048-1","article-title":"To wheeze or not to wheeze: the question of RSV prevention","volume":"6","author":"O'Brien","year":"2018","journal-title":"Lancet Respir Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"046","DOI":"10.1055\/s-0037-1606565","article-title":"Wheeze after hospitalization for respiratory syncytial virus infection in children","volume":"13","author":"Stensballe","year":"2018","journal-title":"J Pediatr Infect Dis."},{"key":"B10","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.jaci.2005.01.057","article-title":"Effects of viral respiratory infections on lung development and childhood asthma","volume":"115","author":"Gern","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.jaci.2006.12.669","article-title":"Early-life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma","volume":"119","author":"Kusel","year":"2007","journal-title":"J Allergy Clin Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"E38","DOI":"10.1542\/peds.106.3.e38","article-title":"Early respiratory infections and childhood asthma","volume":"106","author":"Nafstad","year":"2000","journal-title":"Pediatrics."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1111\/j.1651-2227.2012.02825.x","article-title":"Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?","volume":"101","author":"Drysdale","year":"2012","journal-title":"Acta Paediatr."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1590\/S1806-37132009001200010","article-title":"Genetic associations with asthma and virus- induced wheezing: a systematic review","volume":"35","author":"Pinto","year":"2009","journal-title":"J Bras Pneumol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.ebiom.2016.08.011","article-title":"Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants","volume":"11","author":"High","year":"2016","journal-title":"EBioMedicine."},{"key":"B16","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1136\/adc.66.1.124","article-title":"Recurrent wheezy bronchitis, and viral respiratory infections","volume":"66","author":"Mertsola","year":"1991","journal-title":"Arch Dis Child."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1164\/rccm.200809-1471OC","article-title":"Exploring the association between severe respiratory syncytial virus infection and asthma: a registry-based twin study","volume":"179","author":"Thomsen","year":"2009","journal-title":"Am J Respir Crit Care Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/S0140-6736(15)00156-7","article-title":"Risk factors for asthma: is prevention possible?","volume":"386","author":"Beasley","year":"2015","journal-title":"Lancet."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1183\/09031936.00047714","article-title":"Viral infections, and asthma: an inflammatory interface?","volume":"44","author":"Oliver","year":"2014","journal-title":"Eur Respir J."},{"key":"B20","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1164\/rccm.200802-309OC","article-title":"Wheezing rhinovirus illnesses in early life predict asthma development in high-risk children","volume":"178","author":"Jackson","year":"2008","journal-title":"Am J Respir Crit Care Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.4103\/ijmr.IJMR_840_15","article-title":"Viral aetiology of wheezing in children under five","volume":"145","author":"Mummidi","year":"2017","journal-title":"Indian J Med Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.jaci.2019.07.023","article-title":"ORMDL3 and allergic asthma: from physiology to pathology","volume":"144","author":"James","year":"2019","journal-title":"J Allergy Clin Immunol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.4168\/aair.2015.7.2.175","article-title":"The association of GSDMB and ORMDL3 gene polymorphisms with asthma: a meta-analysis","volume":"7","author":"Zhao","year":"2015","journal-title":"Allergy Asthma Immunol Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"981","DOI":"10.3109\/02770903.2015.1044251","article-title":"IL-17 polymorphisms and asthma risk: a meta-analysis of 11 single nucleotide polymorphisms","volume":"52","author":"Jin","year":"2015","journal-title":"J Asthma."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.3892\/etm.2018.7096","article-title":"Correlation between IL-4 and IL-13 gene polymorphisms and asthma in Uygur children in Xinjiang","volume":"17","author":"Zhang","year":"2019","journal-title":"Exp Ther Med."},{"key":"B26","first-page":"111","article-title":"The role of interleukin-4 and 13 gene polymorphisms in allergic rhinitis: a case control study","volume":"8","author":"Shirking","year":"2019","journal-title":"Rep Biochem Mol Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.advms.2015.07.003","article-title":"Polymorphisms in the interleukin 4, interleukin 4 receptor and interleukin 13 genes and allergic phenotype: a case control study","volume":"61","author":"Narozna","year":"2016","journal-title":"Adv Med Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"31165","DOI":"10.1038\/srep31165","article-title":"Post-bronchiolitis wheezing is associated with toll-like receptor 9 rs187084 gene polymorphism","volume":"6","author":"Nuolivirta","year":"2016","journal-title":"Sci Rep."},{"key":"B29","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/iid3.385","article-title":"Association of a four-gene model with allergic diseases: two-year follow-up of a birth cohort study","volume":"9","author":"Hua","year":"2021","journal-title":"Immun Inflamm Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"300060520929179","DOI":"10.1177\/0300060520929179","article-title":"Relationship between interleukin-13 rs20541 single nucleotide polymorphisms and therapeutic efficacy in children with asthma","volume":"48","author":"Liu","year":"2020","journal-title":"J Int Med Res."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.666423\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T07:11:51Z","timestamp":1627369911000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.666423\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,27]]},"references-count":30,"alternative-id":["10.3389\/fped.2021.666423"],"URL":"https:\/\/doi.org\/10.3389\/fped.2021.666423","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,27]]},"article-number":"666423"}}