{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T05:47:01Z","timestamp":1781243221200,"version":"3.54.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016274","name":"Omron Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Given that wheezing is treated with inhaled \u03b22-agonists, their effect should be reviewed before the condition becomes severe; however, few methods can currently predict reactivity to inhaled \u03b22-agonists. We investigated whether preinhalation wheezing characteristics identified by lung sound analysis can predict reactivity to inhaled \u03b22-agonists.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> In 202 children aged 10\u2013153 months, wheezing was identified by auscultation. Lung sounds were recorded for 30 s in the chest region on the chest wall during tidal breathing. We analyzed the wheezing before and after \u03b22-agonist inhalation. Wheezing was displayed as horizontal bars of intensity defined as a wheeze power band, and the wheezing characteristics (number, frequency, and maximum intensity frequency) were evaluated by lung sound analysis. The participants were divided into two groups: non-disappears (wheezing did not disappear after inhalation) and disappears (wheezing disappeared after inhalation). Wheezing characteristics before \u03b22-agonist inhalation were compared between the two groups.<\/jats:p><jats:p>The characteristics of wheezing were not affected by body size. The number of wheeze power bands of the non-responder group was significantly higher than those of the responder group (<jats:italic>P<\/jats:italic> &amp;lt; 0.001). The number of wheeze power bands was a predictor of reactivity to inhaled \u03b22-agonists, with a cutoff of 11.1. The 95% confidence intervals of sensitivity, specificity, and positive and negative predictive values were 88.8, 42, 44, and 81.1% (<jats:italic>P<\/jats:italic> &amp;lt; 0.001), respectively.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The number of preinhalation wheeze power bands shown by lung sound analysis was a useful indicator before treatment. This indicator could be a beneficial index for managing wheezing in young children.<\/jats:p>","DOI":"10.3389\/fped.2021.667094","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T17:51:17Z","timestamp":1633110677000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Wheezing Characteristics and Predicting Reactivity to Inhaled \u03b22-Agonist in Children for Home Medical 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