{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:39:32Z","timestamp":1790120372955,"version":"4.0.1"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Asphyxia is an emergent condition in neonates that may influence the function of the nervous system. Research has shown that intestinal microbiota is very important for neurodevelopment. Studies regarding the association between gut microbiota and neurodevelopment outcome in asphyxiated newborns remain scarce.<\/jats:p><jats:p><jats:bold>Objective:<\/jats:bold> To study the microbial characteristics of asphyxiated neonates within 1 week of life and to investigate their relationship with neural development at 6 months.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The feces produced on days 1, 3, and 5, and the clinical data of full-term neonates with asphyxia and without asphyxia, delivered from March 2019 to October 2020 at Peking University First Hospital, were collected. We used 16S ribosomal deoxyribonucleic acid amplicon sequencing to detect the intestinal microbiota of asphyxiated neonates and neonates in the control group. We followed up asphyxiated neonates for 6 months and used the Ages and Stages Questionnaires-3 (ASQ-3) to evaluate their development.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> A total of 45 neonates were enrolled in the study group and 32 were enrolled in the control group. On day 1, the diversity and richness of the microflora of the study group were more than those of the control group. Non-metric multidimensional scaling analysis showed significant differences in the microbiota of the two groups on days 1, 3, and 5. At the phylum level, the main microflora of the two groups were not different. At the genus level, the study group had increased relative abundance of <jats:italic>Clostridium_sensu_stricto_1, Lachnoclostridium, Fusicatenibacter<\/jats:italic>, etc. on day 1. On day 3, the relative abundance of <jats:italic>Clostridium_sensu_stricto_1, Fusicatenibacter<\/jats:italic>, etc. was still greater than that of the control group, and the relative abundance of <jats:italic>Staphylococcus<\/jats:italic> was less than that of the control group. On day 5, the relative abundance of <jats:italic>Clostridium_sensu_stricto_1<\/jats:italic> and <jats:italic>Lachnoclostridium<\/jats:italic> was still higher than that of the control group, and the relative abundance of <jats:italic>Dubosiella<\/jats:italic> in the study group was significantly increased. At the species level, on day 3, the relative abundance of <jats:italic>Staphylococcus caprae<\/jats:italic> in the study group was less than that in the control group. Linear discriminant analysis effect size showed that the microbiota of the study group mainly consisted of <jats:italic>Lachnospiraceae<\/jats:italic> and <jats:italic>Clostridia<\/jats:italic> on day 1 and <jats:italic>Clostridia<\/jats:italic> on day 3. In the control group, <jats:italic>Staphylococcus<\/jats:italic> was the dominant bacterium on day 3. Neonates in the study group were followed up for 6 months, and the communication score of ASQ-3 was negatively correlated with the relative abundance of <jats:italic>Lachnospiraceae<\/jats:italic> and <jats:italic>Clostridia<\/jats:italic> on day 1.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> The diversity and richness of the microbiota of asphyxiated neonates on the first day of life were significantly increased and mainly consisted of pathogenic flora. <jats:italic>Lachnospiraceae<\/jats:italic> and <jats:italic>Clostridia<\/jats:italic> found in neonates with asphyxia on day 1 of life may be related to neural development at 6 months.<\/jats:p>","DOI":"10.3389\/fped.2021.690339","type":"journal-article","created":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T12:50:36Z","timestamp":1629723036000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months"],"prefix":"10.3389","volume":"9","author":[{"given":"Xiaojiao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"B1","first-page":"222","volume-title":"Practice of Neonatology","author":"Shao","year":"2015"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.7499\/j.issn.1008-8830.2019.01.002","article-title":"Incidence of neonatal asphyxia and contributing factors for the development of severe asphyxia in Hubei Enshi Tujia and Miao Autonomous Prefecture: a multicenter study","volume":"21","author":"Wu","year":"2019","journal-title":"Chin J Contemp Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.19757\/j.cnki.issn1674-7763.2019.01.007","article-title":"A study on attention deficit hyperactivity disorder (ADHD) among preschool children in Liuzhou city","volume":"10","author":"Nu","year":"2019","journal-title":"Chin J Women Children Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2877","DOI":"10.7620\/zgfybj.j.issn.1001-4411.2018.12.81","article-title":"Meta-analysis of risk factors for autism spectrum diseases in Chinese children","volume":"12","author":"Yin","year":"2018","journal-title":"Maternal Child Health Care China"},{"key":"B5","doi-asserted-by":"publisher","first-page":"806248","DOI":"10.1155\/2015\/806248","article-title":"Effects of surgical and dietary weight loss therapy for obesity on gut microbiota composition and nutrient absorption","volume":"2015","author":"Damms-Machado","year":"2015","journal-title":"Biomed Res Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1007\/s10096-017-3060-2","article-title":"Close association between intestinal microbiota and irritable bowel syndrome","volume":"36","author":"Fan","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3389\/fncel.2017.00120","article-title":"The gut microbiota and autism spectrum disorders","volume":"11","author":"Li","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.siny.2016.04.012","article-title":"Fetal, neonatal, and infant microbiome: perturbations and subsequent effects on brain development and behavior","volume":"21","author":"Heijtz","year":"2016","journal-title":"Semin Fetal Neonatal Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1001\/jamapediatrics.2013.497","article-title":"Effect of intestinal microbial ecology on the developing brain","volume":"167","author":"Douglas-Escobar","year":"2013","journal-title":"JAMA Pediatrics."},{"key":"B10","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cell.2020.08.047","article-title":"Maternal fecal microbiota transplantation in cesarean-born infants rapidly restores normal gut microbial development: a proof-of-concept study","volume":"183","author":"Korpela","year":"2020","journal-title":"Cell"},{"key":"B11","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1053\/j.gastro.2011.04.052","article-title":"The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice","volume":"141","author":"Bercik","year":"2011","journal-title":"Gastroenterology."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jpsychires.2015.02.021","article-title":"Collective unconscious: how gut microbes shape human behavior","volume":"63","author":"Dinan","year":"2015","journal-title":"J Psychiatr Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behaviour","volume":"108","author":"Heijtz","year":"2011","journal-title":"Proc Natl. Acad Sci USA."},{"key":"B14","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1038\/mp.2013.65","article-title":"Microbiota is essential for social development in the mouse","volume":"19","author":"Desbonnet","year":"2013","journal-title":"Mol Psychiatry."},{"key":"B15","doi-asserted-by":"publisher","first-page":"492","DOI":"10.4161\/cib.15702","article-title":"Effects of intestinal microbiota on anxiety-like behavior","volume":"4","author":"Neufeld","year":"2011","journal-title":"Commun Integr Biol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.3945\/ajcn.111.026435","article-title":"Contrasting effects of Bifidobacterium breve NCIMB 702258 and Bifidobacterium breve DPC 6330 on the composition of murine brain fatty acids and gut microbiota","volume":"95","author":"Wall","year":"2012","journal-title":"Am J Clin Nutr."},{"key":"B17","first-page":"69","article-title":"A double blind, placebo-controlled, crossover-designed probiotic feeding study in children diagnosed with autistic spectrum disorders","volume":"5","author":"Parracho","year":"2010","journal-title":"Int J Probiot Prebiot."},{"key":"B18","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.nut.2011.08.002","article-title":"The level of arabinitol in autistic children after probiotic therapy","volume":"28","author":"Kaluzna-Czaplinska","year":"2012","journal-title":"Nutrition"},{"key":"B19","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1186\/s12888-016-0887-5","article-title":"Gut to brain interaction in autism spectrum disorders: a randomized controlled trial on the role of probiotics on clinical, biochemical and neurophysiological parameters","volume":"16","author":"Santocchi","year":"2016","journal-title":"BMC Psychiatry."},{"key":"B20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40168-016-0225-7","article-title":"Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study","volume":"5","author":"Kang","year":"2017","journal-title":"Microbiome."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.14309\/ajg.0000000000000203","article-title":"Bifidobacterium longum 1714\u2122 strain modulates brain activity of healthy volunteers during social stress","volume":"114","author":"Wang","year":"2019","journal-title":"Am J Gastroenterol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1053\/j.gastro.2013.02.043","article-title":"Consumption of fermented milk product with probiotic modulates brain activity","volume":"144","author":"Tillisch","year":"2013","journal-title":"Gastroenterology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jad.2019.04.043","article-title":"The gut-brain relationship: Investigating the effect of multispecies probiotics on anxiety in a randomized placebo-controlled trial of healthy young adults","volume":"252","author":"Tran","year":"2019","journal-title":"J Affect Disord."},{"key":"B24","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.cgh.2018.10.002","article-title":"The gut\u2013brain axis and the microbiome: mechanisms and clinical implications","volume":"17","author":"Osadchiy","year":"2019","journal-title":"Clin Gastroenterol Hepatol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fped.2016.00139","article-title":"Intestinal bacterial intestinal bacterial colonization in the first 2 weeks of life of Nigerian neonates using standard culture methods","volume":"4","author":"Kigbu","year":"2016","journal-title":"Front Pediatrics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3760\/cma.j.issn.1007-9408.2016.01.002","article-title":"Neonatal asphyxia: consensus recommendations for diagnosis","volume":"19","year":"2016","journal-title":"Chin J Perinat Med."},{"key":"B27","first-page":"44","article-title":"Analysis of risk factors of NICU neonatal infections by Logistic regression model","volume":"54","author":"Chen","year":"2016","journal-title":"China Morden Doctor."},{"key":"B28","doi-asserted-by":"publisher","first-page":"113","DOI":"10.6061\/clinics\/2012(02)05","article-title":"Establishment of the bacterial fecal community during the first month of life in Brazilian newborns","volume":"67","author":"Brandt","year":"2012","journal-title":"Clinics."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e0185569","DOI":"10.1371\/journal.pone.0185569","article-title":"Evolution in fecal bacterial\/viral composition in infants of two central African countries (Gabon and Republic of the Congo) during their first month of life","volume":"12","author":"Brazier","year":"2017","journal-title":"PLoS ONE."},{"key":"B30","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1006\/anae.1997.0102","article-title":"The intestinal microflora during the first weeks of life","volume":"3","author":"Bezirtzoglou","year":"1997","journal-title":"Anaerobe."},{"key":"B31","volume-title":"Diversity of Gut Microbiota Associated with Patients with Major Depressive Disorder","author":"Jiang","year":"2015"},{"key":"B32","doi-asserted-by":"publisher","first-page":"104709","DOI":"10.1016\/j.micpath.2020.104709","article-title":"Dysbiosis of gut microbiota in patients with esophageal cancer","volume":"150","author":"Deng","year":"2020","journal-title":"Microb Pathog."},{"key":"B33","doi-asserted-by":"publisher","first-page":"458","DOI":"10.12775\/JEHS.2020.10.08.056","article-title":"Role of the gut microbiota in human health","volume":"10","author":"Cha\u0142upnik","year":"2020","journal-title":"J Educ Health Sport."},{"key":"B34","doi-asserted-by":"publisher","first-page":"F334","DOI":"10.1136\/archdischild-2012-303035","article-title":"The individual-specific and diverse nature of the preterm infant microbiota","volume":"98","author":"Barrett","year":"2013","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e53838","DOI":"10.1371\/journal.pone.0053838","article-title":"Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS ONE."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1080\/14767058.2017.1319352","article-title":"The influence of maternal vaginal flora on the intestinal colonization in newborns and 3-month- old infants","volume":"31","author":"Gabriel","year":"2017","journal-title":"J Maternal Frtal Neonatal Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1111\/nmo.12378","article-title":"Correlation between the human fecal microbiota and depression","volume":"26","author":"Naseribafrouei","year":"2014","journal-title":"Neurogastroenterol Motil"},{"key":"B38","doi-asserted-by":"publisher","first-page":"118738","DOI":"10.1016\/j.lfs.2020.118738","article-title":"Variations in fecal microbial profiles of acute exacerbations and stable chronic obstructive pulmonary disease","volume":"265","author":"Wu","year":"2021","journal-title":"Life Sci"},{"key":"B39","unstructured":"Sulphide-induced energy deficiency in colonic cells is prevented by glucose but not by butyrate32531\n            HulinSJ\n            SinghS\n            ChapmanMAS\n            AllanA\n            LangmanMJS\n            EggoMC\n          10.1046\/j.1365-2036.2002.01164.x11860416Aliment Pharmacol Ther162002"},{"key":"B40","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1136\/gut.34.4.437","article-title":"Sulphate reducing bacteria and hydrogen metabolism in the human large intestine","volume":"34","author":"Gibson","year":"1993","journal-title":"Gut"},{"key":"B41","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.2041-1014.2009.00550.x","article-title":"Desulfovibrio spp. survive within KB cells and modulate inflammatory responses","volume":"25","author":"Bisson-Boutelliez","year":"2010","journal-title":"Mol Oral Microbiol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/apt.16204","article-title":"Fructan-sensitive children with irritable bowel syndrome have distinct gut microbiome signatures","volume":"53","author":"Chumpitazi","year":"2020","journal-title":"Aliment Pharmacol Therapeut."},{"key":"B43","doi-asserted-by":"publisher","first-page":"100294","DOI":"10.1016\/j.ynstr.2021.100294","article-title":"Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota","volume":"14","author":"Maa","year":"2021","journal-title":"Neurobiol Stress"},{"key":"B44","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41366-020-00712-2","article-title":"Identification of gut microbiota and microbial metabolites regulated by an antimicrobial peptide lipocalin 2 in high fat diet-induced obesity","volume":"45","author":"Qiu","year":"2021","journal-title":"Int J Obes"},{"key":"B45","doi-asserted-by":"publisher","first-page":"585995","DOI":"10.3389\/fcell.2020.585995","article-title":"Gut microbiota-related evidence provides new insights into the association between activating transcription factor 4 and development of salt-induced hypertension in mice","volume":"8","author":"Liu","year":"2020","journal-title":"Front Cell Dev Biol."},{"key":"B46","first-page":"450","volume-title":"Zhu Futang Practice of Pediatrics","author":"Jiang","year":"2015"},{"key":"B47","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.biopsych.2017.06.021","article-title":"Infant gut microbiome associated with cognitive development","volume":"83","author":"Carlson","year":"2018","journal-title":"Biol Psychiatry"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e00209","DOI":"10.1128\/mSystems.00857-19","article-title":"Depletion of Blautia species in the microbiota of obese children relates to intestinal inflammation and metabolic phenotype worsening","volume":"5","author":"Ben\u00edtez-P\u00e1ez","year":"2020","journal-title":"mSystems"},{"key":"B49","doi-asserted-by":"publisher","first-page":"104344","DOI":"10.1016\/j.micpath.2020.104344","article-title":"The critical role of Faecalibacterium prausnitzii in human health: an overview","volume":"149","author":"Leylabadlo","year":"2020","journal-title":"Microb Pathog."},{"key":"B50","doi-asserted-by":"publisher","first-page":"4932","DOI":"10.1016\/j.cub.2020.09.063","article-title":"Newly explored Faecalibacterium diversity is connected to age, lifestyle, geography, and disease","volume":"30","author":"De Filippis","year":"2020","journal-title":"Curr Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"366","DOI":"10.4161\/gmic.21287","article-title":"Gut microbial communities modulating brain development and function","volume":"3","author":"Al-Asmakh","year":"2012","journal-title":"Gut Microb."},{"key":"B52","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.chom.2017.11.001","article-title":"Coagulase-negative Staphylococcal strain prevents Staphylococcus aureus colonization and skin infection by blocking quorum sensing","volume":"22","author":"Paharik","year":"","journal-title":"Cell Host Microbe."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4137\/NMI.S41125","article-title":"The inflfluence of early infant-feeding practices on the intestinal microbiome and body composition in infants","volume":"2015","author":"O'Sullivan","year":"2016","journal-title":"Nutr Metab Insights."},{"key":"B54","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1002\/bdrc.21113","article-title":"On the origin of species: factors shaping the establishment of infant's gut microbiota","volume":"105","author":"van Best","year":"2015","journal-title":"Birth Defects Res C Embryo Today."},{"key":"B55","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.chom.2015.04.004","article-title":"Dynamics and stabilization of the human gut microbiome during the first year of life","volume":"17","author":"B\u00e4ckhed","year":"2015","journal-title":"Cell Host Microbe."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e20173716","DOI":"10.1542\/peds.2017-3716","article-title":"Advocacy for improving nutrition in the first 1000 days to support childhood development and adult health","volume":"141","author":"Schwarzenberg","year":"2018","journal-title":"Pediatrics."},{"key":"B57","doi-asserted-by":"publisher","first-page":"902","DOI":"10.1093\/jn\/nxy299","article-title":"Strong multivariate relations exist among milk, oral, and fecal microbiomes in mother-infant dyads during the first six months postpartum","volume":"149","author":"Williams","year":"2019","journal-title":"J Nutr."},{"key":"B58","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.3390\/ijms20133306","article-title":"Bifidobacterium and Lactobacillus composition at species level and gut microbiota diversity in infants before 6 weeks","volume":"20","author":"Yang","year":"2019","journal-title":"Int J Mol Sci."},{"key":"B59","doi-asserted-by":"publisher","first-page":"343ra82","DOI":"10.1126\/scitranslmed.aad7121","article-title":"Antibiotics, birth mode, and diet shape microbiome maturation during early life","volume":"8","author":"Bokulich","year":"2016","journal-title":"Sci Transl Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3389\/fcimb.2015.00003","article-title":"Milk- and solid-feeding practices and daycare attendance are associated with differences in bacterial diversity, predominant communities, and metabolic and immune function of the infant gut microbiome","volume":"5","author":"Thompson","year":"2015","journal-title":"Front Cell Infect Microbiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-018-0216-2","article-title":"Infant diet and maternal gestational weight gain predict early metabolic maturation of gut microbiomes","volume":"24","author":"Baumann-Dudenhoeffer","year":"2018","journal-title":"Nat Med."},{"key":"B62","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1001\/jamapediatrics.2015.3732","article-title":"Association of cesarean delivery and formula supplementation with the intestinal microbiome of 6-week-old infants","volume":"170","author":"Madan","year":"2016","journal-title":"JAMA Pediatr."},{"key":"B63","doi-asserted-by":"publisher","first-page":"11971","DOI":"10.1073\/pnas.1002601107","article-title":"Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns","volume":"107","author":"Dominguez-Bello","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B64","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1111\/cea.12063","article-title":"Meconium microbiota types dominated by lactic acid or enteric bacteria are differentially associated with maternal eczema and respiratory problems in infants","volume":"43","author":"Gosalbes","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e9966","DOI":"10.7759\/cureus.9966","article-title":"Gut microbiome and depression: how microbes affect the way we think","volume":"12","author":"Limbana","year":"2020","journal-title":"Cureus"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.690339\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T12:50:56Z","timestamp":1629723056000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.690339\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,23]]},"references-count":65,"alternative-id":["10.3389\/fped.2021.690339"],"URL":"https:\/\/doi.org\/10.3389\/fped.2021.690339","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,23]]},"article-number":"690339"}}