{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:23:25Z","timestamp":1787027005692,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    <jats:bold>Objective:<\/jats:bold>\n                    This study aims to evaluate safety and success rates of lumbar puncture (LP) and to identify factors associated with adverse events or failure of LP in infants.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    This two-center prospective observational study investigated infants younger than 90 days of age who underwent LP. Need for resuscitation oxygen desaturation (SpO\n                    <jats:sub>2<\/jats:sub>\n                    &amp;lt; 90%), bradycardia and intraventricular hemorrhage were considered adverse events. LP failed if cerebrospinal spinal fluid was not collected or had traces of blood. Logistic regression analysis was used to evaluate whether corrected gestational age (GA), body weight at LP, position, and any respiratory support during LP affected SpO\n                    <jats:sub>2<\/jats:sub>\n                    desaturation or failure of LP.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Among 204 LPs, 134 were performed in full-term and 70 in pre-term born infants. SpO\n                    <jats:sub>2<\/jats:sub>\n                    desaturations occurred during 45 (22.4%) LPs. At multivariate analysis, lower GA at LP (\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt; 0.001), non-invasive respiratory support (\n                    <jats:italic>p<\/jats:italic>\n                    0.007) and mechanical ventilation (\n                    <jats:italic>p<\/jats:italic>\n                    0.004) were associated with SpO\n                    <jats:sub>2<\/jats:sub>\n                    desaturations. Transient, self-resolving bradycardia occurred in 7 (3.4%) infants. Two infants had intraventricular hemorrhage detected within 72 h of LP. No further adverse events were registered. Failure of LP occurred in 38.2% of cases and was not associated with any of the factors evaluated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    LP was safe in most infants. Body weight or GA at LP did not affect LP failure. These data are useful to clinicians, providing information on the safety of the procedure.\n                  <\/jats:p>","DOI":"10.3389\/fped.2021.692652","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T02:19:56Z","timestamp":1623637196000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Safety and Success of Lumbar Puncture in Young Infants: A Prospective Observational Study"],"prefix":"10.3389","volume":"9","author":[{"given":"Luca","family":"Bedetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia","family":"Lugli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Marrozzini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Baraldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Baroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lucaccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria F.","family":"Roversi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Iughetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Berardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.clp.2014.10.004","article-title":"Bacterial meningitis in infants","volume":"42","author":"Ku","year":"2015","journal-title":"Clin Perinatol"},{"key":"B2","first-page":"51","article-title":"Neonatal bacterial meningitis","volume-title":"Minerva Pediatr","author":"Berardi","year":"2010"},{"key":"B3","unstructured":"LondonRCOG PressBacterial Meningitis and Meningococcal Septicaemia: Management of Bacterial Meningitis and Meningococcal Septicaemia in Children and Young People Younger than 16 Years in Primary and Secondary Care2010"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1542\/peds.2012-0541","article-title":"Management of neonates with suspected or proven early-onset bacterial sepsis","volume":"129","year":"2012","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e200593","DOI":"10.1001\/jamapediatrics.2020.0593","article-title":"Early-onset neonatal sepsis 2015 to 2017, the rise of Escherichia coli, and the need for novel prevention strategies","volume":"174","author":"Stoll","year":"2020","journal-title":"JAMA Pediatr"},{"key":"B6","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Early onset neonatal sepsis: the burden of group B Streptococcal and E. coli disease continues","volume":"127","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3126","DOI":"10.3109\/14767058.2015.1114093","article-title":"The burden of early-onset sepsis in Emilia-Romagna (Italy): a 4-year, population-based study","volume":"29","author":"Berardi","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1542\/peds.2005-0519","article-title":"Local anesthetic and stylet styles: factors associated with resident lumbar puncture success","volume":"117","author":"Baxter","year":"2006","journal-title":"Pediatrics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.annemergmed.2006.10.018","article-title":"Risk factors for traumatic or unsuccessful lumbar punctures in children","volume":"49","author":"Nigrovic","year":"2007","journal-title":"Ann Emerg Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12887-020-02050-8","article-title":"\u2018The NeoCLEAR Collaborative Group'. 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