{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:20:10Z","timestamp":1779297610208,"version":"3.51.4"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T00:00:00Z","timestamp":1629072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> This study aimed to evaluate the effects of nasal high-frequency oscillatory ventilation (NHFOV) vs. nasal continuous positive airway pressure (NCPAP) on postextubation respiratory failure (PRF) in infants after congenital heart surgery (CHS).<\/jats:p><jats:p><jats:bold>Method:<\/jats:bold> Eighty infants underwent postoperative invasive mechanical ventilation for more than 12 h and planned extubation. The infants were randomized to undergo either NHFOV or NCPAP after extubation. Primary outcomes were the incidence of PRF and reintubation, the average PaCO<jats:sub>2<\/jats:sub> level, the average oxygenation index (OI), and pulmonary recruitment in the early extubation phase. Secondary outcomes included the NCPAP\/NHFOV time, length of hospital stay, treatment intolerance, signs of discomfort, pneumothorax, adverse hemodynamic effects, nasal trauma, and mortality.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Except for PaCO<jats:sub>2<\/jats:sub> within 12 after extubation (39.3 \u00b1 5.8 vs. 43.6 \u00b1 7.3 mmHg, <jats:italic>p<\/jats:italic> = 0.05), there was no statistically significant difference for any of the primary outcome measure (PRF, reintubation within 12 h after extubation, oxygenation index within 12 h after extubation, or lung volumes on X-ray after extubation) or secondary outcome measures (duration of non-invasive ventilation, duration of hospital stay, ventilation intolerance, signs of discomfort, pneumothorax, nasal trauma, adverse hemodynamic effects, or death prior to discharge), <jats:italic>p<\/jats:italic> &amp;gt; 0.1 for each comparison.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> NHFOV therapy after extubation in infants after CHS was more efficient in improving CO<jats:sub>2<\/jats:sub> cleaning than NCPAP therapy, but there was no difference in other outcomes (PRF, reintubation, oxygenation index, and pulmonary recruitment).<\/jats:p>","DOI":"10.3389\/fped.2021.700632","type":"journal-article","created":{"date-parts":[[2021,8,16]],"date-time":"2021-08-16T09:29:47Z","timestamp":1629106187000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Nasal High-Frequency Oscillatory Ventilation vs. Nasal Continuous Positive Airway Pressure as Therapy for Postextubation Respiratory Failure in Infants After Congenital Heart Surgery"],"prefix":"10.3389","volume":"9","author":[{"given":"Hong-Lin","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Qing","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Peng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Rong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s40560-017-0227-y","article-title":"Complex effects of high-flow nasal cannula therapy on hemodynamics in the pediatric patient after cardiac surgery","volume":"5","author":"Inata","year":"2017","journal-title":"J Intens Care."},{"key":"B2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s40560-017-0226-z","article-title":"Physiological impact of high-flow nasal cannula therapy on postextubation acute respiratory failure after pediatric cardiac surgery: a prospective observational study","volume":"5","author":"Shioji","year":"2017","journal-title":"J Intens Care."},{"key":"B3","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.chest.2019.01.014","article-title":"Nasal high-frequency oscillatory ventilation in preterm infants with respiratory distress syndrome and ARDS after extubation: a randomized controlled trial","volume":"155","author":"Chen","year":"2019","journal-title":"Chest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1111\/vec.12816","article-title":"Effects of continuous positive airway pressure on respiratory function in sedated foals","volume":"29","author":"Raidal","year":"2019","journal-title":"J Vet Emerg Crit Care."},{"key":"B5","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1186\/s12887-019-1625-1","article-title":"NASal OscillatioN post-Extubation (NASONE) study group. 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