{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:12:21Z","timestamp":1753891941666,"version":"3.41.2"},"reference-count":14,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T00:00:00Z","timestamp":1625788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>In this case report, we describe the clinical course of a neonate who presented initially with respiratory distress and later with choking during feeding. He was subsequently found to have an esophageal bronchus to the right upper lung lobe, a rare communicating bronchopulmonary foregut malformation. Histological and molecular analysis of the fistula and distal tissues revealed that the proximal epithelium from the esophageal bronchus has characteristics of both esophageal and respiratory epithelia. Using whole exome sequencing of the patient's and parent's DNA, we identified gene variants that are predicted to impact protein function and thus could potentially contribute to the phenotype. These will be the subject of future functional analysis.<\/jats:p>","DOI":"10.3389\/fped.2021.707822","type":"journal-article","created":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:47:00Z","timestamp":1625806020000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Esophageal Bronchus in a Neonate, With Image, Histological, and Molecular Analysis"],"prefix":"10.3389","volume":"9","author":[{"given":"Stephen L.","family":"Trisno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nara S.","family":"Higano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Kechele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talia","family":"Nasr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron M.","family":"Zorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Kingma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"92","DOI":"10.4103\/0971-9261.151558","article-title":"Esophageal lung: a rare type of communicating bronchopulmonary foregut malformation, case report with review of literature","volume":"20","author":"Bokka","year":"2015","journal-title":"J Indian Assoc Pediatr Surg."},{"key":"B2","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1007\/s00247-016-3724-6","article-title":"Computed tomography and upper gastrointestinal series findings of esophageal bronchi in infants","volume":"47","author":"Colleran","year":"2017","journal-title":"Pediatr Radiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1016\/S0022-3468(88)80224-0","article-title":"Review of bronchopulmonary foregut malformations","volume":"23","author":"Fowler","year":"1988","journal-title":"J Pediatr Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1056\/NEJM196806272782602","article-title":"Congenital bronchopulmonary-foregut malformation","volume":"278","author":"Gerle","year":"1968","journal-title":"N Engl J Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1002\/jmri.25394","article-title":"Pulmonary MRI of neonates in the intensive care unit using 3D ultrashort echo time and a small footprint MRI system","volume":"45","author":"Hahn","year":"2017","journal-title":"J Magn Reson Imaging."},{"key":"B6","doi-asserted-by":"publisher","first-page":"46","DOI":"10.2214\/ajr.126.1.46","article-title":"Bronchopulmonary foregut malformations. A unifying etiological concept","volume":"126","author":"Heithoff","year":"1974","journal-title":"Am J Roentgenol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.epsc.2017.10.001","article-title":"Pre- and post-operative visualization of neonatal esophageal atresia\/tracheoesophageal fistula via magnetic resonance imaging","volume":"29","author":"Higano","year":"2018","journal-title":"J Pediatr Surg Case Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/ppul.20827","article-title":"Bronchial anomalies in VACTERL association","volume":"43","author":"Kanu","year":"2008","journal-title":"Pediatr Pulmonol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e6307","DOI":"10.1097\/MD.0000000000006307","article-title":"Diagnosis and treatment of communicating bronchopulmonary foregut malformation: report of two cases and review of the literature","volume":"96","author":"Ren","year":"2017","journal-title":"Medicine."},{"key":"B10","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/S0022-3468(99)90087-8","article-title":"Esophageal lung with multiple congenital anomalies: conundrums in diagnosis and management","volume":"34","author":"Saydam","year":"1999","journal-title":"J Pediatr Surg."},{"key":"B11","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s00383-004-1359-4","article-title":"P. Reimplantation of oesophageal bronchus following a type III oesophageal atresia repair","volume":"21","author":"Seguier-Lipszyc","year":"2005","journal-title":"Pediatr Surg Int."},{"key":"B12","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/S0022-3468(05)80103-4","article-title":"Communicating bronchopulmonary foregut malformations: classification and embryogenesis","volume":"27","author":"Srikanth","year":"1992","journal-title":"J Pediatr Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.jpedsurg.2011.04.057","article-title":"Esophageal lung: presentation, management, and review of literature","volume":"46","author":"Sugandhi","year":"2011","journal-title":"J Pediatr Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1038\/s41431-020-0680-2","article-title":"Novel candidate genes in esophageal atresia\/tracheoesophageal fistula identified by exome sequencing","volume":"29","author":"Wang","year":"2021","journal-title":"Eur J Hum Genet."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.707822\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,9]],"date-time":"2021-07-09T04:47:04Z","timestamp":1625806024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.707822\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,9]]},"references-count":14,"alternative-id":["10.3389\/fped.2021.707822"],"URL":"https:\/\/doi.org\/10.3389\/fped.2021.707822","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2021,7,9]]},"article-number":"707822"}}