{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:24:43Z","timestamp":1791973483149,"version":"4.4.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The aim of this study is to provide new data on pediatrics spondylodiscitis for an optimal clinical management of this site-specific osteomyelitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We reported 48 cases of pediatric spondylodiscitis and made three comparisons between: (1) tubercular and non-tubercular cases; (2) patients aged more or less than 5 years; (3) children with spondylodiscitis and 62 controls with non-vertebral osteomyelitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    A higher rate of sequelae was reported in patients with tubercular spondylodiscitis, but no significant differences were noted at the cut-off of 5 years of age. Compared to non-vertebral osteomyelitis, pediatric spondylodiscitis affects younger children of both genders, usually presenting with afebrile back pain, and requiring longer time to admission, hospitalization, and antibiotic therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Pediatric spondylodiscitis is an insidious disease with a non-specific presentation in childhood and peculiarities of its own. However, when clinical remission is obtained by an early start of broad-spectrum antibiotics, prolonging the therapy does not improve, nor worsens, the outcome. Surgical management is mandatory in case of vertebral instability and neurological signs but can be avoided when the infection is promptly treated with antibiotic therapy.\n                  <\/jats:p>","DOI":"10.3389\/fped.2021.727031","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T03:22:45Z","timestamp":1634786565000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Spondylodiscitis in Children: A Retrospective Study and Comparison With Non-vertebral Osteomyelitis"],"prefix":"10.3389","volume":"9","author":[{"given":"Marco","family":"Roversi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Mirra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Musolino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Barbuti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lancella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Deriu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Iorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Villani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Crostelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Mazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Krzysztofiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/01.brs.0000152097.57891.98","article-title":"Spondylodiscitis in childhood: results of a long-term study","volume":"30","author":"Kayser","year":"2005","journal-title":"Spine."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1542\/peds.105.6.1299","article-title":"Discitis and vertebral osteomyelitis in children: an 18-year review","volume":"105","author":"Fernandez","year":"2000","journal-title":"Pediatrics."},{"key":"B3","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3390\/antibiotics10010030","article-title":"Characteristics, management and outcomes of spondylodiscitis in children: a Systematic review","volume":"10","author":"Ferri","year":"2020","journal-title":"Antibiotics."},{"key":"B4","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1302\/0301-620X.100B4.BJJ-2017-1080.R1","article-title":"Spinal infections in children: a multicentre retrospective study","author":"Dayer","year":"2018","journal-title":"Bone Joint J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1111\/clm.12031","article-title":"Prospective survey of acute osteoarticular infections in a French paediatric orthopedic surgery unit","volume":"19","author":"Ferroni","year":"2013","journal-title":"Clin Microbiol Infect."},{"key":"B6","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1136\/archdischild-2013-305860","article-title":"Community-acquired bone and joint infections in children: a 1-year prospective epidemiological study","volume":"100","author":"Mitha","year":"2015","journal-title":"Arch Dis Child."},{"key":"B7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1471-2431-8-45","article-title":"Childhood osteomyelitis-incidence and differentiation from other acute onset musculoskeletal features in a population-based study","volume":"8","author":"Riise","year":"2008","journal-title":"BMC Pediatr."},{"key":"B8","doi-asserted-by":"publisher","first-page":"e26","DOI":"10.1093\/cid\/civ482","article-title":"Infectious Diseases Society of America. (2015) infectious diseases society of america (idsa) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults","volume":"61","author":"Berbari","year":"2015","journal-title":"Clin Infect Dis"},{"key":"B9","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.jinf.2008.02.005","article-title":"Infectious spondylodiscitis","volume":"56","author":"Cottle","year":"2008","journal-title":"J Infect."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1007\/s00381-019-04470-z","article-title":"Paediatric spondylodiscitis: a 10-year single institution experience in management and clinical outcomes","volume":"36","author":"Afshari","year":"2020","journal-title":"Childs Nerv Syst."},{"key":"B11","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00586-018-5598-9","article-title":"Multidisciplinary management of pyogenic spondylodiscitis: epidemiological and clinical features, prognostic factors and long-term outcomes in 207 patients","volume":"27","author":"Pola","year":"2018","journal-title":"Eur Spine J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"875","DOI":"10.3238\/arztebl.2017.0875","article-title":"Spondylodiscitis: diagnosis and treatment options","volume":"114","author":"Herren","year":"2017","journal-title":"Dtsch Arztebl Int."},{"key":"B13","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1007\/s00586-015-4318-y","article-title":"Outcome of conservative and surgical treatment of pyogenic spondylodiscitis: a systematic literature review","volume":"25","author":"Rutges","year":"2016","journal-title":"Eur Spine J."},{"key":"B14","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1186\/s12891-021-04155-2","article-title":"Early surgery with antibiotic medication was effective and efficient in treating pyogenic spondylodiscitis","volume":"22","author":"Guo","year":"2021","journal-title":"BMC Musculoskelet Disord."},{"key":"B15","doi-asserted-by":"publisher","first-page":"539","DOI":"10.3390\/ijms17040539","article-title":"Infectious discitis and spondylodiscitis in children","volume":"17","author":"Principi","year":"2016","journal-title":"Int J Mol Sci."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.727031\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T03:22:47Z","timestamp":1634786567000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.727031\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,21]]},"references-count":15,"alternative-id":["10.3389\/fped.2021.727031"],"URL":"https:\/\/doi.org\/10.3389\/fped.2021.727031","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,21]]},"article-number":"727031"}}