{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T22:11:48Z","timestamp":1790892708006,"version":"4.1.0"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Sepsis is responsible for a massive burden of disease, with a global estimate of 48.9 million cases resulting in approximately 11 million deaths annually. Survivors of sepsis may also experience long-term impairments that can persist for years after hospital discharge. These cognitive, physical and\/or psychosocial deficits may contribute to a lower health related quality of life and represent a significant ongoing burden to the individual, the community and the health care system. We aim to systematically review the available evidence on long-term functional and quality of life outcomes after sepsis in children and adults.<\/jats:p><jats:p><jats:bold>Data Sources:<\/jats:bold> Medline, EMBASE, and CINAHL will be searched for eligible studies.<\/jats:p><jats:p><jats:bold>Study Selection:<\/jats:bold> Studies of adult and pediatric survivors of sepsis who had required admission to intensive care will be included. A minimum 6 month prospective follow up will be required. Accepted outcomes will be any validated measure of health-related quality of life (HRQoL) or functional deficits, using the Post-Intensive Care Syndrome (PICS) framework of cognitive, physical or psychosocial outcomes.<\/jats:p><jats:p><jats:bold>Data Extraction:<\/jats:bold> Data extraction will include information related to study characteristics, population characteristics, clinical criteria and outcomes.<\/jats:p><jats:p><jats:bold>Data Synthesis:<\/jats:bold> Studies meeting the inclusion criteria will be presented descriptively separated for pediatric and adult age groups. Meta-analysis will be attempted if sufficient primary data from several studies applying the same tests and outcomes are available. The primary outcome is HRQoL after sepsis; secondary outcomes include the functional status at follow-up.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> This systematic review will define the long-term impact of sepsis survivorship. The data will contribute to informing patient, clinician and stakeholder decisions and guide further research and resource management.<\/jats:p>","DOI":"10.3389\/fped.2021.734205","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T06:16:55Z","timestamp":1635142615000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Long-Term Functional Outcomes After Sepsis for Adult and Pediatric Critical Care Patients\u2014Protocol for a Systematic Review"],"prefix":"10.3389","volume":"9","author":[{"given":"Adam","family":"Simpson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Fleischmann-Struzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessicah","family":"Minogue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balasubramanian","family":"Venkatesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naomi E.","family":"Hammond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luregn J.","family":"Schlapbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA."},{"key":"B2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1001\/jamapediatrics.2017.5208","article-title":"Defining pediatric sepsis","volume":"172","author":"Schlapbach","year":"2018","journal-title":"JAMA Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet."},{"key":"B4","doi-asserted-by":"publisher","first-page":"L518","DOI":"10.1152\/ajplung.00369.2020","article-title":"World Sepsis Day: a global agenda to target a leading cause of morbidity and mortality","volume":"319","author":"Schlapbach","year":"2020","journal-title":"Am J Physiol Lung Cell Mol Physiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1056\/NEJMp1707170","article-title":"Recognizing sepsis as a global health priority - A WHO resolution","volume":"377","author":"Reinhart","year":"2017","journal-title":"N Engl J Med."},{"key":"B7","doi-asserted-by":"publisher","first-page":"e625","DOI":"10.1097\/PCC.0000000000001340","article-title":"Sepsis in children: global implications of the world health assembly resolution on sepsis","volume":"18","author":"Kissoon","year":"2017","journal-title":"Pediatr Crit Care Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"395","DOI":"10.5694\/mja2.50279","article-title":"The WHO resolution on sepsis: what action is needed in Australia?","volume":"211","author":"Schlapbach","year":"2019","journal-title":"Med J Aust."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"JAMA."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1007\/s00134-017-4701-8","article-title":"Australian, O. 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