{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:16:55Z","timestamp":1792030615192,"version":"4.4.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007560","name":"Chiesi Farmaceutici","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007560","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>\n                    <jats:bold>Aim:<\/jats:bold>\n                    To establish the impact of oxygen requirement before surfactant (SF) and time from birth to SF administration on treatment outcomes in neonatal respiratory distress syndrome (RDS).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    We conducted a\n                    <jats:italic>post-hoc<\/jats:italic>\n                    analysis of data from a prospective cohort study of 500 premature infants treated with less invasive surfactant administration (LISA). LISA failure was defined as the need for early (&amp;lt;72 h of life) mechanical ventilation (MV). Baseline clinical characteristic parameters, time to SF, and fraction of inspired oxygen (FiO\n                    <jats:sub>2<\/jats:sub>\n                    ) prior to SF were all included in the multifactorial logistic regression model that explained LISA failure.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    LISA failed in 114 of 500 infants (22.8%). The median time to SF was 2.1 h (IQR: 0.8\u20136.7), and the median FiO\n                    <jats:sub>2<\/jats:sub>\n                    prior to SF was 0.40 (IQR: 0.35\u20130.50). Factors significantly associated with LISA failure were FiO\n                    <jats:sub>2<\/jats:sub>\n                    prior to SF (OR 1.03, 95% CI 1.01\u20131.04) and gestational age (OR 0.82, 95 CI 0.75\u20130.89); both\n                    <jats:italic>p<\/jats:italic>\n                    &amp;lt;0.001. Time to SF was not an independent risk factor for therapy failure (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.528) or the need for MV at any time during hospitalization (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.933).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    The FiO\n                    <jats:sub>2<\/jats:sub>\n                    before SF, but not time to SF, influences the need for MV in infants with RDS. While our findings support the relevance of FiO\n                    <jats:sub>2<\/jats:sub>\n                    in SF prescription, better adherence to the recommended FiO\n                    <jats:sub>2<\/jats:sub>\n                    threshold for SF (0.30) is required in daily practice.\n                  <\/jats:p>","DOI":"10.3389\/fped.2021.734696","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T01:33:43Z","timestamp":1633311223000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["FiO2 Before Surfactant, but Not Time to Surfactant, Affects Outcomes in Infants With Respiratory Distress Syndrome"],"prefix":"10.3389","volume":"9","author":[{"given":"Piotr","family":"Kruczek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Krajewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Ho\u017cejowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"Szczapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1055\/s-2004-823779","article-title":"A randomized, multicenter masked comparison trial of poractant alfa (Curosurf) versus beractant (Survanta) in the treatment of respiratory distress syndrome in preterm infants","volume":"21","author":"Ramanathan","year":"2004","journal-title":"Am J Perinatol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1038\/jp.2010.20","article-title":"Poractant alfa and beractant treatment of very premature infants with respiratory distress syndrome","volume":"30","author":"Fujii","year":"2010","journal-title":"J Perinatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1055\/s-0031-1295648","article-title":"A randomized, controlled trial of poractant alfa versus beractant in the treatment of preterm infants with respiratory distress syndrome","volume":"29","author":"Dizdar","year":"2012","journal-title":"Am J Perinatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"603716","DOI":"10.3389\/fped.2020.603716","article-title":"Dose effect of poractant alfa in neonatal RDS: analysis of combined data from three prospective studies","volume":"8","author":"Kr\u00f3lak-Olejnik","year":"2020","journal-title":"Front Pediatr."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001456","article-title":"Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome","author":"Yost","year":"2000","journal-title":"Cochrane Database Syst Rev."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000513783","article-title":"Personalized medicine for the management of RDS in preterm neonates","volume":"18","author":"De Luca","year":"2021","journal-title":"Neonatology."},{"key":"B7","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1159\/000297773","article-title":"European Association of Perinatal Medicine. 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