{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:31:23Z","timestamp":1792690283166,"version":"4.5.0"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p><jats:bold>Objectives:<\/jats:bold> To describe the clinical characteristics of hip involvement in juvenile idiopathic arthritis (JIA) from arthritis to hip osteoarthritis (HOA) and total hip arthroplasty (THA).<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Seven hundred fifty-three patients aged 2\u201317 years with JIA were included in the study. The comparison analysis was performed between the following subgroups: (i) JIA without hip involvement (<jats:italic>n<\/jats:italic> = 600; 79.7%) vs. JIA with hip involvement without HOA (<jats:italic>n<\/jats:italic> = 105; 13.9%), (ii) JIA with hip involvement with HOA, but without THA (<jats:italic>n<\/jats:italic> = 32; 4.3%) and JIA with hip involvement with HOA and with THA (<jats:italic>n<\/jats:italic> = 16; 2.1%). Clinical, laboratory characteristics and treatment regimens compared.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Hip involvement was present in 20.3% of patients. HOA was present in 6.4% (12<jats:sup>*<\/jats:sup>1,000 patient-years) of the entire JIA group and 31.4% of patients with hip involvement. Sixteen patients (2.1%; 4.0<jats:sup>*<\/jats:sup>1,000 patient-years) required THA. The following factors were associated with HOA: sJIA (OR = 3.6, <jats:italic>p<\/jats:italic> = 0.008; HR = 3.0, <jats:italic>p<\/jats:italic> = 0.002), delayed remission (OR = 4.2, <jats:italic>p<\/jats:italic> = 0.004; HR = 1.4, <jats:italic>p<\/jats:italic> = 0.538), delay in biologic therapy initiation (OR = 7.5, <jats:italic>p<\/jats:italic> = 0.00001; HR = 6.7, <jats:italic>p<\/jats:italic> = 0.002), alkaline phosphatase &amp;lt;165 U\\l (OR = 4.1, <jats:italic>p<\/jats:italic> = 0.0003; HR = 5.2, <jats:italic>p<\/jats:italic> = 0.000004), treatment with corticosteroids (CS) (OR = 2.6, <jats:italic>p<\/jats:italic> = 0.008; HR = 1.2, <jats:italic>p<\/jats:italic> = 0.670), cumulative corticosteroids &amp;gt;2,700 mg (OR = 4.3, <jats:italic>p<\/jats:italic> = 0.032; HR = 1.4, <jats:italic>p<\/jats:italic> = 0.527). The following factors were associated with THA: delay in biologic treatment initiation (OR = 1.04, <jats:italic>p<\/jats:italic> = 0.0001; HR = 9.1, <jats:italic>p<\/jats:italic> = 0.034), delayed hip involvement (OR = 5.2, <jats:italic>p<\/jats:italic> = 0.002; HR = 3.0, <jats:italic>p<\/jats:italic> = 0.044), and methylprednisolone pulse therapy (OR = 10.8, <jats:italic>p<\/jats:italic> = 0.0000001; HR = 5.6, <jats:italic>p<\/jats:italic> = 0.002).<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Both sJIA and systemic CS, impaired calcium-phosphorus metabolism, and delayed hip arthritis are associated with HOA development in JIA. HOA is considered to be a severe adverse event of CS treatment, especially delayed hip involvement.<\/jats:p>","DOI":"10.3389\/fped.2021.747779","type":"journal-article","created":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T11:08:25Z","timestamp":1636110505000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":18,"title":["Hip Involvement in Juvenile Idiopathic Arthritis: A Roadmap From Arthritis to Total Hip Arthroplasty or How Can We Prevent Hip Damage?"],"prefix":"10.3389","volume":"9","author":[{"given":"Lubov S.","family":"Sorokina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilia S.","family":"Avrusin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinat K.","family":"Raupov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia A.","family":"Lubimova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Khrypov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail M.","family":"Kostik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"B1","first-page":"390","article-title":"International league of associations for rheumatology. 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