{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:24Z","timestamp":1753891884407,"version":"3.41.2"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Vitamin B12 deficiency in childhood presents with a wide variety of symptoms including anemia, failure to thrive and developmental delays. It is a diagnostic consideration in children who are exclusively breastfed or have minimal solid intake, especially if their mother is vegetarian or has underlying vitamin B12 deficiency. Infantile tremor syndrome (ITS) has been associated with vitamin B12 deficiency. ITS presents with neurological symptoms such as developmental delays and tremors. The tremors seen in ITS can be profound and interfere with daily functioning. Different therapies have been tried for those tremors without much evidence or information regarding their efficacy and dosing regimens. We present the case of a 13-month-old girl with vitamin B12 deficiency who developed ITS with significant tremors after initiation of vitamin B12 therapy. She was treated with propranolol which resulted in significant improvement in her tremors. This case highlights the efficacy and safety of propranolol for the treatment of ITS in the context of vitamin B12 deficiency.<\/jats:p>","DOI":"10.3389\/fped.2021.774747","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:54:10Z","timestamp":1638298450000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Propranolol Therapy for Infantile Tremor Syndrome in a Child With Vitamin B12 Deficiency"],"prefix":"10.3389","volume":"9","author":[{"given":"Am\u00e9lie","family":"Cyr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan","family":"Frehlick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Stammers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan","family":"Crone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"152","DOI":"10.11604\/pamj.2018.30.152.12046","article-title":"Psychomotor regression due to vitamin B12 deficiency","volume":"30","author":"Bousselamti","year":"2018","journal-title":"Pan Afr Med J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1093\/tropej\/fmx062","article-title":"Case series of infantile tremor syndrome in tertiary care Paediatric Centre from Southern India","volume":"64","author":"Gowda","year":"2018","journal-title":"J Trop Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1503\/cmaj.112170","article-title":"Vitamin B12 deficiency in infants secondary to maternal causes","volume":"184","author":"Roumeliotis","year":"2012","journal-title":"CMAJ."},{"key":"B4","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3121\/cmr.4.3.236","article-title":"Megaloblastic anemia and other causes of macrocytosis","volume":"4","author":"Aslinia","year":"2006","journal-title":"Clin Med Res."},{"key":"B5","unstructured":"MeansR\n            FairfieldK\n          Clinical Manifestations and Diagnosis of Vitamin B12 and Folate Deficiency2021"},{"key":"B6","doi-asserted-by":"publisher","first-page":"298","DOI":"10.4103\/1817-1745.199475","article-title":"Infantile tremor syndrome: a review and critical appraisal of its etiology","volume":"11","author":"Goraya","year":"2016","journal-title":"J Pediatr Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3390\/medicina56020088","article-title":"Nutritional status and the influence of the vegan diet on the gut microbiota and human health","volume":"56","author":"Sakkas","year":"2020","journal-title":"Medicina."},{"key":"B8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.arcped.2007.01.014","article-title":"Stagnation pond\u00e9rale et r\u00e9gression psychomotrice r\u00e9v\u00e9lant une carence en vitamine B12 chez 3 nourrissons. Underweight and psychomotor regression revealing vitamin B12 deficiency in 3 infants","volume":"14","author":"Mathey","year":"2007","journal-title":"Arch Pediatr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1684\/epd.2012.0507","article-title":"Involuntary movements after correction of vitamin B12 deficiency: a video-case report","volume":"14","author":"Zanus","year":"2012","journal-title":"Epileptic Disord."},{"key":"B10","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1055\/a-0981-6355","article-title":"Infantile tremor syndrome after peroral and intramuscular vitamin B12 therapy: two cases","volume":"231","author":"Tun\u00e7er","year":"2019","journal-title":"Zwei F\u00e4lle Klin Padiatr."},{"key":"B11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.2147\/RRTM.S180604","article-title":"Infantile tremor syndrome: current perspectives","volume":"10","author":"Gupta","year":"2019","journal-title":"Res Rep Trop Med."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.774747\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T18:54:13Z","timestamp":1638298453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.774747\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":11,"alternative-id":["10.3389\/fped.2021.774747"],"URL":"https:\/\/doi.org\/10.3389\/fped.2021.774747","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"article-number":"774747"}}