{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:08:42Z","timestamp":1792249722892,"version":"4.4.0"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 EY010572"],"award-info":[{"award-number":["P30 EY010572"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY019474"],"award-info":[{"award-number":["R01 EY019474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HD107494"],"award-info":[{"award-number":["R01 HD107494"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Recent advances in portable optical coherence tomography (OCT) and OCT angiography (OCTA) have resulted in wider fields of view (FOV) and shorter capture times, further expanding the potential clinical role of OCT technology in the diagnosis and management of retinopathy of prematurity (ROP). Using a prototype, handheld OCT device, retinal imaging was obtained in non-sedated infants in the neonatal intensive care unit (NICU) as well as sedated infants in the operating room of Oregon Health &amp;amp; Science University (OHSU) Hospital. In this observational study, we provide an overview of potential advantages of OCT-based disease assessment in ROP. We observed that next-generation OCT imaging (a) may be sufficient for objective diagnosis and zone\/stage\/plus disease categorization, (b) allows for minimally-invasive longitudinal monitoring of disease progression and post-treatment course, (c) provides three-dimensional mapping of the vitreoretinal interface, and (d) with OCTA, enables dye-free visualization of normal and pathologic vascular development.<\/jats:p>","DOI":"10.3389\/fped.2021.797684","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T18:36:40Z","timestamp":1642531000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":33,"title":["Advantages of Widefield Optical Coherence Tomography in the Diagnosis of Retinopathy of Prematurity"],"prefix":"10.3389","volume":"9","author":[{"given":"Thanh-Tin P.","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuibin","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanjida","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Ostmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Peter","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,1,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1001\/archophthalmol.2009.361","article-title":"Retinoschisis detected with handheld spectral-domain optical coherence tomography in neonates with advanced retinopathy of prematurity","volume":"128","author":"Muni","year":"2010","journal-title":"Arch Ophthalmol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.ophtha.2006.01.007","article-title":"Optical coherence tomography findings in stage 4A retinopathy of prematurity: a theory for visual variability","volume":"113","author":"Joshi","year":"2006","journal-title":"Ophthalmology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"5183","DOI":"10.1167\/iovs.10-7155","article-title":"Understanding clinically undetected macular changes in early retinopathy of prematurity on spectral domain optical coherence tomography","volume":"52","author":"Vinekar","year":"2011","journal-title":"Investig Ophthalmol Visual Sci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"468653","DOI":"10.1155\/2014\/468653","article-title":"Macular findings obtained by spectral domain optical coherence tomography in retinopathy of prematurity","volume":"2014","author":"Erol","year":"2014","journal-title":"J. Ophthalmol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1016\/j.ophtha.2013.12.004","article-title":"Three-dimensional assessment of vascular and perivascular characteristics in subjects with retinopathy of prematurity","volume":"121","author":"Maldonado","year":"2014","journal-title":"Ophthalmology."},{"key":"B6","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.oret.2018.02.001","article-title":"Spectral-domain OCT findings of retinal vascular-avascular junction in infants with retinopathy of prematurity","volume":"2","author":"Chen","year":"2018","journal-title":"Ophthalmol Retina."},{"key":"B7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00417-019-04274-6","article-title":"Three-dimensional pattern of extraretinal neovascular development in retinopathy of prematurity","volume":"257","author":"Mangalesh","year":"2019","journal-title":"Graefe's Arch Clin Experi Ophthalmol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1016\/j.oret.2020.03.027","article-title":"Vitreous findings by handheld spectral-domain oct correlate with retinopathy of prematurity severity","volume":"4","author":"Legocki","year":"2020","journal-title":"Ophthalmol Retina."},{"key":"B9","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1016\/j.ophtha.2011.05.028","article-title":"Dynamics of human foveal development after premature birth","volume":"118","author":"Maldonado","year":"2011","journal-title":"Ophthalmology."},{"key":"B10","doi-asserted-by":"publisher","first-page":"OCT69","DOI":"10.1167\/iovs.15-18825","article-title":"Pediatric optical coherence tomography in clinical practice-recent progress","volume":"57","author":"Lee","year":"2016","journal-title":"Investig Ophthalmol Visual Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1167\/tvst.9.11.25","article-title":"Repeatability and reproducibility of axial and lateral measurements on handheld optical coherence tomography systems compared with tabletop system","volume":"9","author":"Chen","year":"2020","journal-title":"Translational Vision Sci Technol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.21037\/qims.2019.09.01","article-title":"Handheld swept-source optical coherence tomography with angiography in awake premature neonates","volume":"9","author":"Moshiri","year":"2019","journal-title":"Quant Imaging Med Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1001\/jamaophthalmol.2017.2481","article-title":"Handheld optical coherence tomography angiography and ultra-wide-field optical coherence tomography in retinopathy of prematurity","volume":"135","author":"Campbell","year":"2017","journal-title":"JAMA ophthalmology."},{"key":"B14","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1364\/BOE.10.002623","article-title":"Ergonomic handheld OCT angiography probe optimized for pediatric and supine imaging","volume":"10","author":"Viehland","year":"2019","journal-title":"Biomed Optics Express."},{"key":"B15","doi-asserted-by":"publisher","first-page":"100094","DOI":"10.1101\/2021.10.14.21265026","article-title":"Peripheral optical coherence tomography assisted by scleral depression in retinopathy of prematurity","author":"Scruggs","year":"2021","journal-title":"Ophthalmol Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.1364\/BOE.425411","article-title":"High-speed and widefield handheld swept-source OCT angiography with a VCSEL light source","volume":"12","author":"Ni","year":"2021","journal-title":"Biomed Optics Express."},{"key":"B17","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1201\/9781420005615.ax4","article-title":"Image processing with ImageJ","volume":"11","author":"Abr\u00e0moff","year":"2004","journal-title":"Biophotonics Int."},{"key":"B18","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fninf.2014.00013","article-title":"ITK: enabling reproducible research and open science","volume":"8","author":"McCormick","year":"2014","journal-title":"Front. Neuroinform."},{"key":"B19","year":"2021"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2419","DOI":"10.1364\/BOE.420503","article-title":"Phase-stabilized complex-decorrelation angiography","volume":"12","author":"Wei","year":"2021","journal-title":"Biomed Optics Express."},{"key":"B21","doi-asserted-by":"publisher","first-page":"4429","DOI":"10.1364\/BOE.9.004429","article-title":"Automated segmentation of retinal layer boundaries and capillary plexuses in wide-field optical coherence tomographic angiography","volume":"9","author":"Guo","year":"2018","journal-title":"Biomed Optics Express."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-021-84723-7","article-title":"Key factors in a rigorous longitudinal image-based assessment of retinopathy of prematurity","volume":"11","author":"Rosenblatt","year":"2021","journal-title":"Sci Rep."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1001\/jamaophthalmol.2019.2442","article-title":"A quantitative severity scale for retinopathy of prematurity using deep learning to monitor disease regression after treatment","volume":"137","author":"Gupta","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.ophtha.2020.10.025","article-title":"Evaluation of a deep learning-derived quantitative retinopathy of prematurity severity scale","volume":"128","author":"Campbell","year":"2021","journal-title":"Ophthalmology."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1001\/jamaophthalmol.2019.2433","article-title":"Monitoring disease progression with a quantitative severity scale for retinopathy of prematurity using deep learning","volume":"137","author":"Taylor","year":"2019","journal-title":"JAMA Ophthalmol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1601","DOI":"10.1016\/j.ophtha.2015.04.023","article-title":"Influence of fluorescein angiography on the diagnosis and management of retinopathy of prematurity","volume":"122","author":"Klufas","year":"2015","journal-title":"Ophthalmology."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2021-319254","article-title":"Associations between systemic health and retinal nerve fibre layer thickness in preterm infants at 36 weeks postmenstrual age","author":"Shen","year":"2021","journal-title":"Br J Ophthalmol."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.797684\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T18:36:42Z","timestamp":1642531002000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2021.797684\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":27,"alternative-id":["10.3389\/fped.2021.797684"],"URL":"https:\/\/doi.org\/10.3389\/fped.2021.797684","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,18]]},"article-number":"797684"}}