{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T15:26:35Z","timestamp":1774279595521,"version":"3.50.1"},"reference-count":19,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>We initially described two children who developed Guillain-Barr\u00e9 syndrome (GBS) complicated by rhabdomyolysis (RML), and reviewed five adult patients from the literature. Through analysis of the clinical features, laboratory examination, treatment and prognostic data from these seven patients, we found that when GBS \u201cmeets\u201d RML, the most prominent characteristics were the following: male dominance; limb weakness, pain and respiratory failure could be caused by multiple factors; limb weakness and respiratory muscle paralysis were more serious than with GBS alone; and the probability of mechanical ventilation was increased. Neuroelectrophysiological studies revealed axonal lesions. Close monitoring and timely identification and intervention to remedy potentially fatal complications such as electrolyte disorder multisystem complications and kidney injury are crucial. With plasma exchange, peritoneal dialysis and supportive treatment, the long-term outcome of most patients was satisfactory.<\/jats:p>","DOI":"10.3389\/fped.2022.1001775","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T12:04:13Z","timestamp":1665403453000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Guillain-Barr\u00e9 syndrome (GBS) complicated by rhabdomyolysis (RML): Case reports of 2 children and literature review"],"prefix":"10.3389","volume":"10","author":[{"given":"Xin-Ying","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong-Li","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Lan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/S0140-6736(21)00517-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"397","author":"Shahrizaila","year":"2021","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1016\/S0140-6736(16)00339-1","article-title":"Guillain-Barr\u00e9 syndrome","volume":"388","author":"Willison","year":"2016","journal-title":"Lancet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1186\/s12883-020-01796-z","article-title":"Clinical features of Guillain-Barr\u00e9 syndrome patients with elevated serum creatine kinase levels","volume":"20","author":"Hosokawa","year":"2020","journal-title":"BMC Neurol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1159\/000508747","article-title":"HyperCKemia in Guillain-Barr\u00e9 syndrome","volume":"83","author":"Choi","year":"2020","journal-title":"Eur Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1136\/pgmj.67.783.73","article-title":"Acute rhabdomyolysis associated with atypical Guillain-Barr\u00e9 syndrome","volume":"67","author":"Scott","year":"1991","journal-title":"Postgrad Med J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1097\/CND.0000000000000175","article-title":"Atypical Asymmetric Guillain-Barr\u00e9 Syndrome With Acute Rhabdomyolysis","volume":"19","author":"Hargis","year":"2017","journal-title":"J Clin Neuromuscul Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"241","DOI":"10.4103\/0972-5229.130577","article-title":"Guillain-Barre syndrome complicated by acute fatal rhabdomyolysis","volume":"18","author":"Saxena","year":"2014","journal-title":"Indian J Crit Care Med."},{"key":"B8","first-page":"305","article-title":"Mycoplasma pneumonia associated with rhabdomyolysis and the Guillain-Barre syndrome","volume":"47","author":"Gupta","year":"2005","journal-title":"Indian J Chest Dis Allied Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1186\/s12879-020-05506-5","article-title":"Concurrent acute myositis and Guillain-Barre syndrome in Cytomegalovirus infection - 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