{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:59Z","timestamp":1753891919077,"version":"3.41.2"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T00:00:00Z","timestamp":1664150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Childhood Guillain\u2013Barr\u00e9 syndrome (GBS) is a rare neurological disease. Early diagnosis followed by precise treatment can reduce mortality. In this study, we collected two transcriptome data between GBS and controls from the publicly available databases (GEO dataset). We identified two distinct down-regulated genes (PTGDS and AR) in GBS by transcriptome analysis (<jats:italic>n<\/jats:italic> = 20). Based on the two distinct down-regulated genes in the GBS group, a two-gene diagnostic signature was developed. Moreover, gene expression analysis for the two-gene was performed on a patient with GBS before and after Supportive Care. RT\u2013PCR results show that the expression of PTGDS increased after the patient was given supportive care. Therefore, PTGDS might be considered as a potential target for therapeutic target in GBS.<\/jats:p>","DOI":"10.3389\/fped.2022.1008996","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:37:39Z","timestamp":1664185059000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcriptome analysis of childhood Guillain\u2013Barr\u00e9 syndrome associated with supportive 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