{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:25:50Z","timestamp":1788881150526,"version":"build-2803163510"},"reference-count":13,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Posterior urethral valves are urethral leaflets that cause Lower Urinary Tract Obstruction (LUTO) in boys and are associated with congenital renal dysplasia and abnormal bladder function. They affect 1:4,000 to 1:25,000 births and can be responsible for End-Stage Renal Failure in childhood. There have been several studies on the effect of pop-off mechanisms in boys with posterior urethral valves, but results are contradictory. We aimed to assess and discuss the effect of pop-off mechanisms on renal function in a large cohort of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and method<\/jats:title><jats:p>Boys with PUV with and without pop-off mechanisms (urinoma, VURD or giant bladder diverticula) were divided into three severity groups for renal function according to their nadir creatinine (low-risk NC\u2009&amp;lt;\u200935\u2005\u03bcmol\/L, intermediate-risk NC between 35 and 75\u2005\u03bcmol\/L, and high-risk NC\u2009&amp;gt;\u200975\u2005\u03bcmol\/L). We compared children with and children without pop-off mechanisms for mean renal function as well as patient distribution within each severity group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 137 boys of which 39 had a pop-off mechanism. Patients had complete data for at least 5 years follow-up. Though there was no significant statistical difference in mean renal function between the pop-off and non-pop-off group, patient distribution within each severity group varied according to whether patients had a pop-off mechanism or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Though there was no significant difference in mean renal function between boys with and without pop-off mechanisms, it is possible that these are two different patient populations and direct comparison is not possible.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.1014422","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T05:00:10Z","timestamp":1666069210000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Evaluating the impact of pop-off mechanisms in boys with posterior urethral valves"],"prefix":"10.3389","volume":"10","author":[{"given":"T.","family":"Delefortrie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Ferdynus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Paye-Jaouen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Michel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Dobremez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Peycelon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"El Ghoneimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Harper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1016\/S0022-5347(17)41908-2","article-title":"Protective factors in posterior urethral valves","volume":"140","author":"Rittenberg","year":"1988","journal-title":"J Urol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1007\/BF02011386","article-title":"Urinoma formation in posterior urethral valves: relationship to later renal function","volume":"20","author":"Fernbach","year":"1990","journal-title":"Ped. 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Urol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.jpurol.2010.08.002","article-title":"Timing of posterior urethral valve diagnosis and its impact on clinical outcome","volume":"7","author":"Kibar","year":"2011","journal-title":"J Pediatr Urol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.jpurol.2009.06.016","article-title":"Long-term upper and lower urinary tract functions in children with posterior urethral valves","volume":"6","author":"Otukesh","year":"2010","journal-title":"J Pediatr Urol"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1014422\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T05:00:12Z","timestamp":1666069212000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1014422\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":13,"alternative-id":["10.3389\/fped.2022.1014422"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.1014422","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"article-number":"1014422"}}