{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:23Z","timestamp":1785434783891,"version":"3.56.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T00:00:00Z","timestamp":1670803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009330","name":"Medical Science and Technology Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["A2022152"],"award-info":[{"award-number":["A2022152"]}],"id":[{"id":"10.13039\/501100009330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The occurrence of gestational diabetes mellitus (GDM) is caused by a variety of factors and associated with increased risks of several adverse outcomes for both mothers and infants. However, the effects of epidural labor analgesia in parturients with GDM on maternal and infant outcomes have not been characterized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>According to parturients' choice, they were divided into the epidural group (<jats:italic>n<\/jats:italic>\u2009=\u2009133) and no epidural (control) group (<jats:italic>n<\/jats:italic>\u2009=\u2009135). Data for relative variables in the perinatal period were collected, and the potential associations of epidural labor analgesia with infant outcomes were analyzed by univariate analysis and multivariate logistic regression analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The rate of neonatal admission to the neonatal intensive care unit (NICU) for hypoglycemia was higher in the epidural group (7.52%) than in the control group (1.48%; <jats:italic>P<\/jats:italic>\u2009&amp;lt;\u20090.05). Epidural labor analgesia and drug-based diabetes control were independent predictors of the rate of neonate transfer to the NICU for hypoglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Epidural labor analgesia was associated with an increased risk of neonatal transfer to the NICU for hypoglycemia. Thus, monitoring of neonatal blood glucose levels after administration of epidural labor analgesia in parturients with GDM may be beneficial.<\/jats:p><jats:p><jats:bold>Trial registration:<\/jats:bold> The study was registered in the China Clinical Registration Center (Registration No. ChiCTR-OOC-17013164, Registered on 30 October 2017).<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.1022291","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:21:23Z","timestamp":1670822483000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of epidural labor analgesia on maternal and infant outcomes in parturients with gestational diabetes mellitus\u2014A prospective cohort study"],"prefix":"10.3389","volume":"10","author":[{"given":"Gehui","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuhong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingguang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuantao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"399","DOI":"10.15537\/smj.2015.4.10307","article-title":"Gestational diabetes mellitus","volume":"36","author":"Alfadhli","year":"2015","journal-title":"Saudi Med J"},{"key":"B2","first-page":"154","volume-title":"J Diabetes Investig.","author":"Gao","year":"2019"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e17113","DOI":"10.7759\/cureus.17113","article-title":"Factors associated with gestational diabetes mellitus: a cross-sectional study","volume":"13","author":"Wagan","year":"2021","journal-title":"Cureus"},{"key":"B4","doi-asserted-by":"publisher","first-page":"e1545","DOI":"10.1542\/peds.2009-2257","article-title":"Hyperglycemia and adverse pregnancy outcome study: neonatal glycemia | American academy of pediatrics","volume":"126","author":"Metzger","year":"2010","journal-title":"Pediatrics"},{"key":"B5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/1471-2393-8-23","article-title":"Use of real time continuous glucose monitoring and intravenous insulin in type 1 diabetic mothers to prevent respiratory distress and hypoglycaemia in infants","volume":"8","author":"Iafusco","year":"2008","journal-title":"BMC Pregnancy Childbirth"},{"key":"B6","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/s0889-8529(05)70208-5","article-title":"Neuroendocrinology of stress","volume":"30","author":"Habib","year":"2001","journal-title":"Endocrinol Metab Clin North Am"},{"key":"B7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1093\/bja\/56.3.251","article-title":"Maternal and umbilical cord plasma noradrenaline concentrations during labour with and without segmental extradural analgesia, and during caesarean section","volume":"56","author":"Jouppila","year":"1984","journal-title":"Br J Anaesth"},{"key":"B8","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1007\/BF03012090","article-title":"Epidural\u00a0analgesia in early labour blocks the stress response but uterine contractions remain unchanged","volume":"45","author":"Scull","year":"1998","journal-title":"Can J Anaesth"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1093\/eurheartj\/ehs114","article-title":"Do observational studies using propensity score methods agree with randomized trials? 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