{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:56:13Z","timestamp":1793382973953,"version":"4.5.0"},"reference-count":52,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Children with severe adenoviral pneumonia (ADVP) have poor prognosis and high risk of mortality. We performed a meta-analysis to evaluate the association between pretreatment lactate dehydrogenase (LDH) and severity, postinfectious bronchiolitis obliterans (PIBO), and mortality in children with ADVP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Relevant observational studies were identified by search of PubMed, Embase, Web of Science, Wanfang, and CNKI databases from inception to August 3, 2022. A random effect model was used to pool the results by incorporating the potential between-study heterogeneity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 23 studies with 4,481 children with ADVP were included in this meta-analysis. Results of meta-analysis showed that children with severe ADVP had a significantly higher level of pretreatment LDH as compared to those with non-severe ADVP (standard mean difference [SMD]: 0.51, 95% confidence interval [CI]: 0.36 to 0.66, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200969%). Besides, pooled results also suggested that the pretreatment LDH was significantly higher in children who developed PIBO as compared to those who did not (SMD: 0.47, 95% CI: 0.09 to 0.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.02, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200980%). Finally, results of the meta-analysis also confirmed that a higher pretreatment LDH (&amp;gt;500\u2005IU\/L) was a risk factor of increased mortality during hospitalization (odds ratio: 3.10, 95% CI: 1.62 to 5.92, <jats:italic>p<\/jats:italic>\u2009&amp;lt;\u20090.001, <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090%). Sensitivity analyses by excluding one dataset at a time showed consistent results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High pretreatment LDH may be associated with disease severity, development of PIBO, and increased risk of mortality in children with ADVP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.1059728","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T06:24:57Z","timestamp":1674714297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Lactate dehydrogenase and the severity of adenoviral pneumonia in\u00a0children: A 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