{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:40Z","timestamp":1753891900476,"version":"3.41.2"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The health\u2014related quality of life (HRQoL) concept is nowadays increasingly and more broadly used for helping evaluate the effectiveness of medical treatment, superseding the earlier \u201cquality of life\u201d approach. The HRQoL concept likewise applies to otolaryngology and this narrative review study is focused on HRQoL outcomes in four key childhood otolaryngological diseases as reported in the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study aim<\/jats:title><jats:p>To retrospectively evaluate the literature on measuring HRQoL in children suffering from selected otolaryngological illnesses, during treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Published studies\/case reports were searched for in Medline, PubMed, Web of Science, Scopus and ORCID on the quality of life based on paediatric patient questionnaires, whether completed by subjects themselves or by their parents (by proxy). The following key words were used: health quality of life, otolaryngology\/ENT, pediatrics\/paediatrics. Studies before 1999 were omitted because hitherto, the \u201cquality of life\u201d had been imprecisely defined thus rendering any subsequent comparisions problematic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HRQoL scores and well-being were found to significantly deteriorate in child patients suffering from four important otolaryngological disorders: chronic sinusitis, nasal septum deviation, adenoid hypertrophy and hearing disease. The main problems found were infection, inflammation, disruption to family life and child-parental interaction, fitness-related issues, reduced ENT patencies and apnea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The HRQoL appears to significantly deteriorate in children suffering from otolaryngological diseases. Further such studies are needed for other ENT diseases.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.1077198","type":"journal-article","created":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T06:07:58Z","timestamp":1673417278000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["A review of health\u2014related quality of life issues in children suffering from certain key otolaryngological illnesses"],"prefix":"10.3389","volume":"10","author":[{"given":"Lechos\u0142aw Pawe\u0142","family":"Chmielik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gra\u017cyna","family":"Mielnik\u2013Niedzielska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kasprzyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Niedzielski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1001\/jama.1997.03550010061041","article-title":"The problem of quality of life in medicine","volume":"278","author":"Lepl\u00e8ge","year":"1997","journal-title":"JAMA"},{"key":"B2","first-page":"171","article-title":"Jako\u015b\u0107 \u017cycia i oczekiwania terapeutyczne chorych na padaczk\u0119","volume":"11","author":"Ryglewicz","year":"2003","journal-title":"Epileptologia"},{"key":"B3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2174\/17450179021170102534.","article-title":"An overview of the international literature on health-related quality of life, mental health and psychosocial issues in people with cancer","volume":"17","author":"Lindert","year":"2021","journal-title":"Clin Pract Epidemiol Ment Health"},{"key":"B4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.tcmj.2012.09.002","article-title":"Methodological issues in measuring health-related quality of life","volume":"25","author":"Lin","year":"2013","journal-title":"Tzu Chi Med J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1108\/09526860810880162","article-title":"Health-related quality of life measurement","volume":"21","author":"Sajid","year":"2008","journal-title":"Int J Health Care Qual Assur"},{"key":"B6","first-page":"136","article-title":"O badaniach nad jako\u015bci\u0105 \u017cycia i sposobach rozumienia norm","volume":"1","author":"Skrzypek","year":"2000","journal-title":"Alma Mater"},{"key":"B7","first-page":"35","article-title":"Health\u2014related quality of live (HRQL) in children and adolescents\u2014concepts study methods and lecected applications","volume":"7","author":"Mazur","year":"2003","journal-title":"Med Wieku Rozwoj"},{"key":"B8","doi-asserted-by":"publisher","first-page":"622","DOI":"10.7326\/0003-4819-118-8-199304150-00009","article-title":"Measuring health\u2014related quality of life","volume":"118","author":"Guyatt","year":"1993","journal-title":"Ann Inter Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3310\/hta5040","article-title":"Quality of life measures in chronic diseases of childhood","volume":"5","author":"Eiser","year":"2001","journal-title":"Health Technol Assess"},{"key":"B10","article-title":"An exploration of life outcomes measures in scoliosis and cerebral palsy","volume":"104","author":"Vitale","year":"1999","journal-title":"Pediatrics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1111\/j.1651-2227.2002.tb02838.x","article-title":"Export consensus in the development of European heath-related quality of life measure for children and adolescents: a delihi study","volume":"91","author":"Herdman","year":"2002","journal-title":"Acta Paediatr"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2399","DOI":"10.1002\/lary.26522","article-title":"Scoping review of pediatric tonsillectomy quality of life assessment instruments: pediatric tonsillectomy QoL assessment tools","volume":"127","author":"Kao","year":"2017","journal-title":"Laryngoscope"},{"key":"B13","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/icvts\/ivaa258","article-title":"Development of the diaphragmatic paralysis questionnaire: a simple tool for patient relevant outcome","volume":"32","author":"Kosse","year":"2021","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e0197507","DOI":"10.1371\/journal.pone.0197507","article-title":"Health related quality of life in adults after burn injuries: a systematic review","volume":"13","author":"Spronk","year":"2018","journal-title":"PLoS One"},{"key":"B15","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1097\/MEG.0000000000001914","article-title":"Gastroesophageal reflux disease\u2014health-related quality of life questionnaire: prospective development and validation in Italian: prospective development and validation in Italian","volume":"33","author":"Balla","year":"2021","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2174\/1573396313666170615092324","article-title":"A review of the psychometric properties and use of the rheumatoid arthritis quality of life questionnaire (RAQoL) in clinical research","volume":"13","author":"Heaney","year":"2017","journal-title":"Curr Rheumatol Rev"},{"key":"B17","doi-asserted-by":"publisher","first-page":"4912920","DOI":"10.1155\/2020\/4912920","article-title":"Analysis of optimal health-related quality of life measures in patients waitlisted for lung transplantation","volume":"2020","author":"Tokuno","year":"2020","journal-title":"Can Respir J"},{"key":"B18","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1037\/hea0000653","article-title":"Physical activity and health-related quality of life in children and adolescents: a systematic review and meta-analysis","volume":"37","author":"Marker","year":"2018","journal-title":"Health Psychol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"480","DOI":"10.3390\/medicina57050480","article-title":"Health related quality of life T-14 outcomes for pediatric bizact tonsillectomy","volume":"57","author":"Stepan","year":"2021","journal-title":"Medicina"},{"key":"B20","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1001\/jamaoto.2020.0869","article-title":"Effectiveness of adenotonsillectomy vs watchful waiting in young children with mild to moderate obstructive sleep apnea: a randomized clinical trial: a randomized clinical trial","volume":"146","author":"Fehrm","year":"2020","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.ijporl.2014.05.038","article-title":"Quality of life after adenotonsillectomy for children with sleep-disordered breathing: a linear mixed model analysis","volume":"78","author":"Lee","year":"2014","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.sleep.2021.02.057","article-title":"Quality-of-life but not behavior improves 48-months post-adenotonsillectomy in children with SDB","volume":"81","author":"Lushington","year":"2021","journal-title":"Sleep Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/0091217419829988","article-title":"Effect of adenotonsillectomy on sleep problems, attention deficit hyperactivity disorder symptoms, and quality of life of children with adenotonsillar hypertrophy and sleep-disordered breathing","volume":"54","author":"T\u00fcrko\u011flu","year":"2019","journal-title":"Int J Psychiatry Med"},{"key":"B24","first-page":"39","article-title":"Komentarz do artyku\u0142u ocena skuteczno\u015bci tonsillektomii lub adenotonsylektomii w leczeniu nawracaj\u0105cych zapale\u0144 gard\u0142a u dzieci","volume":"6","author":"Hassmann-Pozna\u0144ska","year":"2002","journal-title":"Medycyna Praktyczna Pediatria"},{"key":"B25","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1001\/archotol.126.1.45","article-title":"Quality of life and health status in pediatric tonsil and adenoid disease","volume":"126","author":"Stewart","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B26","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1001\/archotol.130.2.190","article-title":"Quality of life after adenotonsillectomy for obstructive sleep apnea in children","volume":"130","author":"Michell","year":"2004","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1016\/j.ijporl.2009.05.015","article-title":"Child behavior and quality of life before and after tonsillotomy versus tonsillectomy","volume":"73","author":"Ericsson","year":"2009","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1067\/mhn.2000.105254","article-title":"Quality of life for children with obstructive sleep apnea","volume":"123","author":"Francor","year":"2000","journal-title":"Otolareyngogy\u2014Head and Neck Surgery"},{"key":"B29","first-page":"11","article-title":"Niezabiegowe leczenie obturacyjnego leczenia bezdechu podczas snu","volume":"4","author":"Przyby\u0142owski","year":"2005","journal-title":"Niezabiegowe Leczenie Obturacyjnego Bezdechu Podczas Snu Otolaryngologia"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.12968\/hmed.2021.0589","article-title":"Rhinosinusitis and its impact on quality of life in children","volume":"83","author":"Ahmed","year":"2022","journal-title":"Br J Hosp Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30232","article-title":"Quality of life measurement for adolescent patients with sinonasal symptoms","author":"Makary","year":"2022","journal-title":"Laryngoscope"},{"key":"B32","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1016\/j.pedneo.2022.01.008","article-title":"Validation of the traditional Chinese version of the Sinus and nasal quality of life survey (SN-5) for children","volume":"63","author":"Lai","year":"2022","journal-title":"Pediatr Neonatol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"111050","DOI":"10.1016\/j.ijporl.2022.111050","article-title":"Pediatric turbinate radiofrequency ablation improves quality of life and rhinomanometric values. A prospective study","volume":"154","author":"Calvo-Henriquez","year":"2022","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"110425","DOI":"10.1016\/j.ijporl.2020.110425","article-title":"Cross-cultural adaptation of the sinus and nasal quality of life survey (SN-5) to Spanish","volume":"139","author":"Calvo-Henr\u00edquez","year":"2020","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijporl.2016.09.005","article-title":"Quality of life after endoscopic sinus surgery in refractory pediatric chronic rhinosinusitis","volume":"90","author":"Sethi","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1016\/j.otohns.2005.12.033","article-title":"Improvements in quality of life in children after surgical therapy for sinonasal disease","volume":"134","author":"Rudnick","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B37","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1055\/s-2007-966094","article-title":"Polyposis nasi\u2014improvement in quality of life by the influence of leukotrien receptor antagonists","volume":"4","author":"Pauli","year":"2007","journal-title":"Laryngorhinootologie"},{"key":"B38","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1067\/mhn.2003.41","article-title":"Quality of life for children with persistent sinonasal symptoms","volume":"128","author":"Kay","year":"2003","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B39","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/1477-7525-3-68","article-title":"Evaluating change in health\u2014related quality of life in adult rhinitis: responsiveness of the rhinosinusitis disability index","volume":"8","author":"Chen","year":"2005","journal-title":"Health Qual Life Outcomes"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1001\/archotol.126.11.1363","article-title":"The health impact of chronic recurrent rhinosinusitis in children","volume":"126","author":"Cunningham","year":"2000","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4193\/Rhin20.600","article-title":"European Position paper on rhinosinusitis and nasal polyps","volume":"58","author":"Fokens","year":"2020","journal-title":"Rhinology"},{"key":"B42","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00405-018-5229-4","article-title":"Predictive factors of patients\u2019 general quality of life after nasal septoplasty","volume":"276","author":"Valsamidis","year":"2019","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1097\/MOO.0000000000000378","article-title":"Pediatric nasal surgery: timing and technique","volume":"25","author":"Gary","year":"2017","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"B44","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/ped4.12145","article-title":"Quality of life in children following nasal septal surgery: a review of its outcome","volume":"3","author":"Saniasiaya","year":"2019","journal-title":"Pediatr Investig"},{"key":"B45","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijporl.2018.05.016","article-title":"Pediatric septoplasty and functional septorhinoplasty: a quality of life outcome study","volume":"111","author":"Manteghi","year":"2018","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.fsc.2017.06.00947.","article-title":"Issues in pediatric craniofacial trauma","volume":"25","author":"Chandra","year":"2017","journal-title":"Facial Plast Surg Clin North Am"},{"key":"B47","first-page":"167","article-title":"Structural changes in the rat middle ear mucosa due to endotoxin and eustachian tube obstruction","volume-title":"Eur Arch Otorhinolaryngol","author":"Nell","year":"1999"},{"key":"B48","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ijporl.2003.10.013","article-title":"Eustachian tube function and tympanic membrane findings after chronic secretory otitis media","volume":"68","author":"Ryding","year":"2004","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"30","DOI":"10.20344\/amp.9457","article-title":"Qualidade de vida das crian\u00e7as com otite m\u00e9dia e impacto da coloca\u00e7\u00e3o de tubos de ventila\u00e7\u00e3o transtimp\u00e2nicos numa popula\u00e7\u00e3o portuguesa quality of life of children with Otitis media and impact of insertion of transtympanic ventilation tubes in a Portuguese population","volume":"31","author":"Lameiras","year":"2018","journal-title":"Acta Med Port"},{"key":"B50","doi-asserted-by":"publisher","first-page":"110590","DOI":"10.1016\/j.ijporl.2020.110590","article-title":"Hearing-related quality of life, developmental outcomes and performance in children and young adults with unilateral conductive hearing loss due to aural atresia","volume":"142","author":"Smit","year":"2021","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.ijporl.2007.06.001","article-title":"Quality of life outcomes after ventilating tube insertion for otitis media in an Australian population","volume":"71","author":"Chow","year":"2007","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12887-022-03254-w","article-title":"Quality of life in children with cochlear implants in Kazakhstan","volume":"22","author":"Zhumabayev","year":"2022","journal-title":"BMC Pediatr"},{"key":"B53","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ijporl.2011.10.016","article-title":"Screening for pre-school and school-age hearing problems: european consensus statement","volume":"76","author":"Skar\u017cy\u0144ski","year":"2012","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1159\/000500992","article-title":"Changes in hearing threshold and tinnitus severity after stapes surgery: which is more important to the patient's Quality of life?","volume":"81","author":"Dziendziel","year":"2019","journal-title":"ORL J Otorhinolaryngol Relat Spec"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1077198\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T06:08:04Z","timestamp":1673417284000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.1077198\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,11]]},"references-count":54,"alternative-id":["10.3389\/fped.2022.1077198"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.1077198","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2023,1,11]]},"article-number":"1077198"}}