{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T01:58:27Z","timestamp":1793152707684,"version":"4.5.0"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In the year 2015, more than one-third of neonatal deaths caused by prematurity was recorded worldwide. Despite different kinds of efforts taken at the global and local levels to reduce neonatal mortality, it remains high with low reduction rates, especially in low- and middle-income countries like sub-Saharan Africa and South Asia. Therefore, this study aims to assess the survival status and predictors of mortality among preterm neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective follow-up study was conducted on randomly selected 561 preterm neonates. Data were extracted from patient records using a pretested checklist. Data entry and analysis were done using Epi-Data Version 4.4.2.1 and Stata version 14, respectively. The Cox proportional hazard regression model was fitted to identify the predictors of mortality. A hazard ratio with a 95% confidence interval (CI) was estimated and <jats:italic>p<\/jats:italic>-values\u2009&amp;lt;\u20090.05 were considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The proportion of preterm neonatal deaths was 32.1% (180) with an incidence of 36.6 (95% CI: 31.6\u201342.4) per 1,000 person days. The mean survival time was 18.7 (95% CI: 17.7\u201319.9) days. Significant predictors for time to death of preterm neonates were respiratory distress syndrome [adjusted hazard ratio (AHR): 2.04; 95% CI: 1.48\u20132.82], perinatal asphyxia (AHR: 2.13; 95% CI: 1.32\u20133.47), kangaroo mother care (AHR: 0.14; 95% CI: 0.08\u20130.24), and gestational age (AHR: 0.85; 95% CI: 0.80\u20130.90).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preterm neonatal death is still a major public health concern. Respiratory distress syndrome, perinatal asphyxia, kangaroo mother care, and gestational age were independent significant predictors for time to death, as found in this study. Hence, priority must be given to neonates with the above illnesses and strengthen the management and care of preterm neonates.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.1083749","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T04:56:05Z","timestamp":1673585765000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Survival and predictors of mortality among preterm neonates in Northern Ethiopia: A retrospective follow-up study"],"prefix":"10.3389","volume":"10","author":[{"given":"Bekahegn","family":"Girma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailemariam","family":"Berhe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Furtuna","family":"Mekonnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemberu","family":"Nigussie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1016\/S0140-6736(16)31593-8","article-title":"Global, regional, and national causes of under-5 mortality in 2000\u201315: an updated systematic analysis with implications for the sustainable development goals","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/S0140-6736(12)60560-1","article-title":"Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000","volume":"379","author":"Liu","year":"2012","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1016\/S0140-6736(14)61698-6","article-title":"Global, regional, and national causes of child mortality in 2000\u201313, with projections to inform post-2015 priorities: an updated systematic analysis","volume":"385","author":"Liu","year":"2015","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1186\/s12889-015-2232-1","article-title":"Level of mortality risk for babies born preterm or with a small weight for gestation in a tertiary hospital of Nepal","volume":"15","author":"Ashish","year":"2015","journal-title":"BMC Public Health"},{"key":"B5","year":""},{"key":"B6","volume-title":"ICD-10: International statistical classification of diseases and related health problems: Tenth revision","year":"2010"},{"key":"B7","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12912-016-0170-6","article-title":"Pre-term and post-term births: predictors and implications on neonatal mortality in Northern Ethiopia","volume":"15","author":"Mengesha","year":"2016","journal-title":"BMC Nurs"},{"key":"B8","first-page":"46","volume-title":"Neonatal intensive care unit (NICU) training participants manual: Ethiopia","year":"2014"},{"key":"B9","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.jpeds.2015.10.028","article-title":"Survival, hospitalization, and acute-care costs of very and moderate preterm infants in the first 6 years of life: a population-based study","volume":"169","author":"Stephens","year":"2016","journal-title":"J Pediatr"},{"key":"B10","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1097\/01.AOG.0000297311.33046.73","article-title":"Neonatal mortality and morbidity rates in late preterm births compared with births at term","volume":"111","author":"McIntire","year":"2008","journal-title":"Obstet Gynecol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"284","DOI":"10.17354\/ijss\/2016\/629","article-title":"Magnitude of preterm admissions in neonatal intensive care unit of rural medical college hospital","volume":"4","author":"Kuppusamy","year":"2016","journal-title":"Int J Sci Study"},{"key":"B12","volume-title":"Preterm birth: causes, consequences, and prevention","author":"Butler","year":"2007"},{"key":"B13","article-title":"March of dimes, PMNCH, save the children","volume-title":"Born too soon: the global action report on preterm birth","author":"Howson","year":"2012"},{"key":"B14","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/pr.2013.204","article-title":"Preterm birth associated neurodevelopmental impairment estimates at regional and global level for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr Res"},{"key":"B15","first-page":"46","volume-title":"Neonatal intensive care unit (NICU) training participants manual: Ethiopia","year":"2014"},{"key":"B16","first-page":"364","volume-title":"Ethiopia demographic and health survey 2016: key indicators report. 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