{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:19:45Z","timestamp":1790662785457,"version":"4.1.0"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T00:00:00Z","timestamp":1673827200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Infective endocarditis (IE) can cause multiorgan dysfunction and chronic kidney disease, in addition to cardiac sequelae. The presentation may be vague and can manifest as acute glomerulonephritis. While the most common pathogens of infective endocarditis are <jats:italic>Staphylococcus<\/jats:italic> and <jats:italic>Streptococcus<\/jats:italic> species, we report a rare pathogen <jats:italic>Bordetella holmesii<\/jats:italic> causing infective endocarditis associated glomerulonephritis. A 20-year-old male patient with tetralogy of Fallot with pulmonary atresia and aortopulmonary collaterals underwent several cardiac surgeries including prosthetic pulmonary valve replacement in the past. He was admitted for 3 days at an outside hospital for fever, cough, and hemoptysis, and diagnosed with streptococcal pharyngitis, for which he received antibiotics. Five weeks later, he presented to our institution with lower extremity edema and gross hematuria. On examination, he was afebrile, normotensive, had a 7-kg weight gain with anasarca, and a systolic murmur, without rash. Investigations revealed elevated serum creatinine, nephrotic range proteinuria, hematuria, and hypocomplementemia, consistent with acute glomerulonephritis. Given his cardiac history, blood cultures were collected from three sites. Broad-spectrum antibiotics were initiated when he subsequently developed fever. Renal pathology on biopsy showed diffuse proliferative immune complex-mediated glomerulonephritis. Transesophageal echocardiogram visualized a vegetation on the pulmonary valve. <jats:italic>Bordetella holmesii<\/jats:italic> was ultimately cultured from the prior and current hospitalization. A serum sample detecting microbial cell-free DNA sequencing confirmed <jats:italic>Bordetella holmesii<\/jats:italic> at very high levels. After completing 6 weeks of intravenous antibiotics with concurrent angiotensin receptor blockade, his kidney function recovered with improvement in hypocomplementemia and proteinuria. This case report highlights the early recognition and comprehensive evaluation of a rare organism causing IE-associated GN, which allowed for renal recovery and preserved cardiac function.<\/jats:p>","DOI":"10.3389\/fped.2022.1093300","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T04:49:36Z","timestamp":1673844576000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: Bordetella holmesii: A\u00a0rare pathogen causing infective endocarditis associated glomerulonephritis"],"prefix":"10.3389","volume":"10","author":[{"given":"Tara","family":"Gavcovich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malek","family":"Al Barbandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Millan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Isner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J.","family":"Defreitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Glaberson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryso P.","family":"Katsoufis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Chandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaka","family":"Sigurjonsdottir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan A.","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sethuraman","family":"Swaminathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqin","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn L.","family":"Abitbol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wacharee","family":"Seeherunvong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1007\/s00431-021-04062-7","article-title":"Infective endocarditis in paediatric population","volume":"180","author":"Eleyan","year":"2021","journal-title":"Eur J Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.tcm.2020.04.008","article-title":"New approach to managing infective endocarditis","volume":"31","author":"Chirillo","year":"2021","journal-title":"Trends Cardiovasc Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41581-019-0178-8","article-title":"Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis","volume":"16","author":"Satoskar","year":"2020","journal-title":"Nat Rev Nephrol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1038\/ki.2014.424","article-title":"Update on endocarditis-associated glomerulonephritis","volume":"87","author":"Boils","year":"2015","journal-title":"Kidney Int"},{"key":"B5","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/0002-9343(94)90143-0","article-title":"New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. 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