{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T23:19:53Z","timestamp":1785453593821,"version":"3.56.0"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T00:00:00Z","timestamp":1651104000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Subcutaneous fat necrosis of the newborn (SCFN) is a panniculitis that develops in fatty areas after fetal or perinatal distress. Prognosis is generally good with complete regression, but it can be complicated by metabolic abnormalities like hypoglycemia, hypertriglyceridemia, thrombocytopenia, and also potentially life-threatening hypercalcemia. Treatments have included hydration, furosemide and corticosteroids. These treatments can be prolonged for several days and can have complications such as nephrocalcinosis. Use of bisphosphonates has been rarely reported in newborn. We describe a case of severe hypercalcemia complicating subcutaneous fat necrosis in a newborn successfully treated by a single dose of pamidronate after having obtained partial response by therapy with hyperhydration, furosemide and hydrocortisone. When high levels of calcium do not respond to first line therapy with hyperhydration and diuretic therapy, bisphosphonates treatment could be considered a valid choice to treat hypercalcemia and to avoid corticosteroids. Further studies are needed to understand if pamidronate and other bisphosphonates can be considered the first choice in hypercalcemia due to SCFN.<\/jats:p>","DOI":"10.3389\/fped.2022.845424","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T09:20:25Z","timestamp":1651137625000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Safety and Efficacy of Pamidronate in Neonatal Hypercalcemia Caused by Subcutaneous Fat Necrosis: A Case Report"],"prefix":"10.3389","volume":"10","author":[{"given":"Stefano","family":"Martinelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pitea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo Francesco","family":"Gatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Raouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziano","family":"Barera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ottavio","family":"Vitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1007\/s00431-011-1405-x","article-title":"Subcutaneous fat necrosis in newborn\u2014an unusual case and review of literature.","volume":"170","author":"Mitra","year":"2011","journal-title":"Eur J Pediatr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/j.1525-1470.2011.01374.x","article-title":"Extensive subcutaneous fat necrosis of the newborn associated with therapeutic hypothermia.","volume":"29","author":"Hogeling","year":"2012","journal-title":"Pediatr Dermatol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1111\/j.1442-200X.2012.03730.x","article-title":"Subcutaneous fat necrosis after selective head cooling in an infant.","volume":"55","author":"Kuboi","year":"2013","journal-title":"Pediatr Int."},{"key":"B4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1136\/adc.26.125.89","article-title":"Subcutaneous fat necrosis of the newborn.","volume":"26","author":"Holzel","year":"1951","journal-title":"Arch Dis Child."},{"key":"B5","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1525-1470.1993.tb00375.x","article-title":"Subcutaneous fat necrosis of the newborn and hypercalcemia: case report and review of the literature.","volume":"10","author":"Hicks","year":"1993","journal-title":"Pediatr Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1542\/peds.90.1.93","article-title":"Hypercalcemia in association with subcutaneous fat necrosis of the newborn: studies of calcium-regulating hormones.","volume":"90","author":"Cook","year":"1992","journal-title":"Pediatrics."},{"key":"B7","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1542\/peds.2010-3508","article-title":"Subcutaneous fat necrosis after moderate therapeutic hypothermia in neonates.","volume":"128","author":"Strohm","year":"2011","journal-title":"Pediatrics."},{"key":"B8","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/jid.1949.50","article-title":"Subcutaneous fat necrosis of the newborn; certain etiologic considerations.","volume":"12","author":"Noojin","year":"1949","journal-title":"J Invest Dermatol."},{"key":"B9","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1542\/peds.2014-0899","article-title":"Hypothermia and neonatal encephalopathy.","volume":"133","author":"Papile","year":"2014","journal-title":"Pediatrics."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1503\/cmaj.070734","article-title":"A 1-week-old newborn with hypercalcemia and palpable nodules: subcutaneous fat necrosis.","volume":"178","author":"Aljaser","year":"2008","journal-title":"CMAJ."},{"key":"B11","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1111\/j.1365-2133.2008.08844.x","article-title":"Expression of 25-hydroxyvitamin D3-1\u03b1-hydroxylase in subcutaneous fat necrosis.","volume":"160","author":"Farooque","year":"2009","journal-title":"Br J Dermatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1770","DOI":"10.1126\/science.1123933","article-title":"Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.","volume":"311","author":"Liu","year":"2006","journal-title":"Science."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1002\/jbmr.3296","article-title":"Hypercalcemic disorders in children.","volume":"32","author":"Stokes","year":"2017","journal-title":"J Bone Miner Res."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116289","article-title":"Bisphosphonates: the role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use.","volume":"156","author":"Ebetino","year":"2022","journal-title":"Bone."},{"key":"B15","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1056\/NEJM199810013391402","article-title":"Cyclic administration of pamidronate in children with severe osteogenesis imperfecta.","volume":"339","author":"Glorieux","year":"1998","journal-title":"N Engl J Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3803\/EnM.2021.1170","article-title":"Review and update of the risk factors and prevention of antiresorptive-related osteonecrosis of the jaw.","volume":"36","author":"Kim","year":"2021","journal-title":"Endocrinol Metab (Seoul)."},{"key":"B17","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.ijom.2019.08.004","article-title":"Can children be affected by bisphosphonate-related osteonecrosis of the jaw? A systematic review.","volume":"49","author":"Duarte","year":"2020","journal-title":"Int J Oral Maxillofac Surg."},{"key":"B18","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1159\/000092602","article-title":"Pamidronate: treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis.","volume":"65","author":"Alos","year":"2006","journal-title":"Horm Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00431-008-0797-8","article-title":"Effectiveness of pamidronate in severe neonatal hypercalcemia caused by subcutaneous fat necrosis: a case report.","volume":"168","author":"Lombardi","year":"2009","journal-title":"Eur J Pediatr."},{"key":"B20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000151599","article-title":"Commentary on \u2018Pamidronate: treatment for severe hypercalcemia in neonatal subcutaneous fat necrosis\u2019 by Alos N. et al., Horm Res 2006;65:289-294.","volume":"70","author":"Lombet","year":"2008","journal-title":"Horm Res."},{"key":"B21","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1177\/000992280104000407","article-title":"Intravenous bisphosphonate for hypercalcemia accompanying subcutaneous fat necrosis: a novel treatment approach.","volume":"40","author":"Khan","year":"2001","journal-title":"Clin Pediatr (Phila)."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.845424\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T09:20:36Z","timestamp":1651137636000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.845424\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,28]]},"references-count":21,"alternative-id":["10.3389\/fped.2022.845424"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.845424","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,28]]},"article-number":"845424"}}