{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:14:35Z","timestamp":1792851275783,"version":"4.5.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T00:00:00Z","timestamp":1650931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Lung ultrasound is a technique that has rapidly developed in recent years. It is a low-cost, radiation-free, and easy-to-operate tool that can be repeatedly performed at the bedside. Compared to chest X-ray, lung ultrasound has high sensitivity and specificity in the diagnosis of neonatal respiratory distress syndrome, transient tachypnoea of newborns and pneumothorax. Lung ultrasound has been widely used in neonatal intensive care units. However, due to the physical barriers of air, where ultrasonic waves cannot pass and therefore reflection artifacts occur, it has limitations in some other lung diseases and cannot fully substitute for chest X-rays or CT\/MRI scanning. This review describes these limitations in detail and highlights that if clinical symptoms are not effectively alleviated after medical treatment or the clinical presentation is not compatible with the ultrasound appearances, then chest X-rays or CT\/MRI scanning should be performed to avoid misdiagnosis and mistreatment.<\/jats:p>","DOI":"10.3389\/fped.2022.855958","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T03:29:35Z","timestamp":1650943775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Limitations of Bedside Lung Ultrasound in Neonatal Lung Diseases"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiaolei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Si","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/BF02012957","article-title":"Hyaline membrane disease in the newborn: diagnosis by ultrasound","volume":"20","author":"Avni","year":"1990","journal-title":"Pediatr radiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1159\/000113059","article-title":"Lung ultrasound in respiratory distress syndrome: a useful tool for early diagnosis","volume":"94","author":"Copetti","year":"2008","journal-title":"Neonatology."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1016\/j.chest.2015.12.024","article-title":"Lung Ultrasonography to Diagnose Transient Tachypnea of the Newborn","volume":"149","author":"Liu","year":"2016","journal-title":"Chest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1159\/000495911","article-title":"A multicenter lung ultrasound study on transient tachypnea of the neonate","volume":"115","author":"Raimondi","year":"2019","journal-title":"Neonatology."},{"key":"B5","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.jpeds.2016.04.018","article-title":"Lung Ultrasound for Diagnosing Pneumothorax in the Critically Ill Neonate","volume":"175","author":"Raimondi","year":"2016","journal-title":"J Pediatr."},{"key":"B6","doi-asserted-by":"crossref","DOI":"10.1016\/S0378-3782(14)50011-4","article-title":"Lung ultrasound findings in meconium aspiration syndrome","volume-title":"Early Hum Dev.","author":"Piastra","year":"2014"},{"key":"B7","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000493001","article-title":"Lung Ultrasound for the Differential Diagnosis of Respiratory Distress in Neonates","volume":"115","author":"Corsini","year":"2019","journal-title":"Neonatology."},{"key":"B8","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13054-020-2787-9","article-title":"International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC)","volume":"24","author":"Singh","year":"2020","journal-title":"Crit Care."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.21203\/rs.3.rs-568776\/v1","article-title":"Lung ultrasonography decreases radiation exposure in newborns with respiratory distress: a retrospective cohort study","volume":"181","author":"Tandircioglu","year":"2021","journal-title":"Eur J Pediatr."},{"key":"B10","doi-asserted-by":"publisher","first-page":"443","DOI":"10.11152\/mu-3059","article-title":"Lung ultrasound in children, WFUMB review paper (part 2)","volume":"23","author":"Dietrich","year":"2021","journal-title":"Med Ultrason."},{"key":"B11","doi-asserted-by":"publisher","first-page":"S99","DOI":"10.1055\/s-0039-1692131","article-title":"Lung ultrasound: a new tool in the management of congenital lung malformation","volume":"36","author":"Quercia","year":"2019","journal-title":"Am J Perinatol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"1222","DOI":"10.1055\/s-0038-1645861","article-title":"Lung ultrasound findings in congenital pulmonary airway malformation","volume":"35","author":"Yousef","year":"2018","journal-title":"Am J Perinatol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s40477-019-00406-0","article-title":"Congenital lung malformations: a novel application for lung ultrasound?","volume":"26","author":"Merli","year":"2019","journal-title":"J Ultrasound."},{"key":"B14","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s10140-018-1640-9","article-title":"Use of ultrasonography for differentiation between bullae and pneumothorax","volume":"26","author":"Karacabey","year":"2019","journal-title":"Emerg Radiol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s00134-018-5317-3","article-title":"Lung ultrasound in a dyspneic patient with giant bullae","volume":"45","author":"Lichtenstein","year":"2019","journal-title":"Intensive Care Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/s12630-010-9435-9","article-title":"Subcutaneous emphysema: ultrasound barrier","volume":"58","author":"Verniquet","year":"2011","journal-title":"Can J Anaesth."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e44","DOI":"10.1053\/j.jvca.2012.03.003","article-title":"Retromolar placement of a double-lumen tube: novel approach for a difficult airway","volume":"26","author":"Truong","year":"2012","journal-title":"J Cardiothorac Vasc Anesth."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1298","DOI":"10.1016\/j.ajem.2017.04.001","article-title":"Lung ultrasonography to diagnose pneumothorax of the newborn","volume":"35","author":"Liu","year":"2017","journal-title":"Am J Emerg Med."},{"key":"B19","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/jp.2017.140","article-title":"Neonatal lung ultrasound exam guidelines","volume":"38","author":"Kurepa","year":"2018","journal-title":"J Perinatol."},{"key":"B20","article-title":"Point-of-care lung ultrasound in neonatology: classification into descriptive and functional applications","volume-title":"Pediatr Res.","author":"Raimondi","year":"2018"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1016\/j.ajem.2016.07.032","article-title":"Absence of lung sliding is not a reliable sign of pneumothorax in patients with high positive end-expiratory pressure","volume":"34","author":"Markota","year":"2016","journal-title":"Am J Emerg Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1007\/s40477-020-00427-0","article-title":"Not all abolished lung sliding are pneumothorax: the case of a particular lung atelectasis","volume":"24","author":"Boccatonda","year":"2021","journal-title":"J Ultrasound."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1460","DOI":"10.1007\/s00134-014-3402-9","article-title":"Semi-quantification of pneumothorax volume by lung ultrasound","volume":"40","author":"Volpicelli","year":"2014","journal-title":"Intensive Care Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.1016\/j.jpeds.2015.02.016","article-title":"Lung ultrasound: a useful tool for the follow-up of neonatal localized interstitial emphysema","volume":"166","author":"Balcells","year":"2015","journal-title":"J Pediatr."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1007\/s00247-017-3910-1","article-title":"Lung ultrasound for the diagnosis of community-acquired pneumonia in children","volume":"47","author":"Stadler","year":"2017","journal-title":"Pediatr Radiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1378\/chest.13-2852","article-title":"Lung ultrasonography for the diagnosis of severe neonatal pneumonia","volume":"146","author":"Liu","year":"2014","journal-title":"Chest."},{"key":"B27","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1001\/2013.jamapediatrics.107","article-title":"Prospective evaluation of point-of-care ultrasonography for the diagnosis of pneumonia in children and young adults","volume":"167","author":"Shah","year":"2013","journal-title":"JAMA Pediatr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1186\/s12890-018-0750-1","article-title":"Lung ultrasound for the diagnosis of pneumonia in children with acute bronchiolitis","volume":"18","author":"Biagi","year":"2018","journal-title":"BMC Pulm Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/2036-7902-4-16","article-title":"Prospective application of clinician-performed lung ultrasonography during the 2009 H1N1 influenza A pandemic: distinguishing viral from bacterial pneumonia","volume":"4","year":"2012","journal-title":"Crit Ultrasound J"},{"key":"B30","doi-asserted-by":"crossref","DOI":"10.1055\/s-0041-1729880","article-title":"Efficiency of Lung Ultrasonography in the Diagnosis and Follow-up of Viral Pneumonia in Newborn","volume-title":"Am J Perinatol.","author":"\u00d6ktem","year":"2021"},{"key":"B31","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12890-019-0925-4","article-title":"Lung ultrasound in infants with bronchiolitis","volume":"19","author":"Buonsenso","year":"2019","journal-title":"BMC Pulm Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/s12887-015-0380-1","article-title":"Lung ultrasound: a useful tool in diagnosis and management of bronchiolitis","volume":"15","author":"Basile","year":"2015","journal-title":"BMC Pediatr."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.855958\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T03:29:41Z","timestamp":1650943781000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.855958\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,26]]},"references-count":32,"alternative-id":["10.3389\/fped.2022.855958"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.855958","relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.161538296.65652710\/v1","asserted-by":"object"}]},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,26]]},"article-number":"855958"}}