{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T00:03:53Z","timestamp":1784937833423,"version":"3.55.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Many patients with cystic fibrosis (CF) wheeze, and are dubbed as having CF-asthma. Understanding the determinants of such wheezing may avoid unnecessary treatments and open newer treatment avenues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Main: To evaluate the prevalence and characteristics of wheezing and a positive bronchodilatory response (BDR) in children with CF. Secondary: To identify the predictive markers and the impact of current wheezing a positive BDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective single-center study in children with CF. We determined the characteristics of physician-reported wheeze in patients &amp;lt;6 years, and a BDR in patients aged 6\u201317 years. Anthropometric, lung function, laboratory, genetic and microbiological data were recorded in all groups. Variables were compared using the Chi<jats:sup>2<\/jats:sup>and Student<jats:italic>t<\/jats:italic>-tests, and ANOVA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>125 preschool and 69 school-aged children and adolescents with CF were included in the study. 71.2% of patients &amp;lt;6 years of age had had at least one episode of wheezing: 26.3% of patients were Transient Early Wheezers, 12.6% Late Onset Wheezers and 37.9% were Persistent Wheezers. The prevalence of a positive BDR was 73.5, 48.5, and 52.9% in the 6\u20138 years, 10\u201312 years, and 15\u201317 years age groups, respectively. Allergic factors were not predictive of wheezing in preschoolers. In the 6\u20138 years age group, the sum of wheal diameters of allergic skin prick tests (SPT, house dust mite + cat + dog dander) was greater in those with a BDR vs. no BDR (4 [2.0\u20138.8] vs. 1 [0\u20137.0] mm,<jats:italic>p<\/jats:italic>= 0.01). The presence of<jats:italic>Pseudomonas aeruginosa<\/jats:italic>in the bronchial secretions before 3 years of age was not significantly associated with either the presence of wheezing at the age of 6 years or a BDR in school-aged children and adolescents. The proportion of homozygous p.F508del patients was significantly lower in the group of patients who had wheezed by 6 years of age (60% vs. 72.7%,<jats:italic>p<\/jats:italic>= 0.009), but higher in the 6\u20138 years old group with a BDR vs. no BDR (64% vs. 36%,<jats:italic>p<\/jats:italic>= 0.04). Current wheezers at 6 years had a lower mean FEV<jats:sub>1<\/jats:sub>vs. the non-current wheezers (91.5 \u00b1 4.4% vs. 100.9 \u00b1 2.4%;<jats:italic>p<\/jats:italic>= 0.047). Similarly, forced vital capacity (FVC) was significantly lower in the 6\u20138 years old group with BDR vs. no BDR (85 \u00b1 19 vs. 101 \u00b1 21%,<jats:italic>p<\/jats:italic>= 0.015).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Wheezing and BDR are very frequent findings in children with CF. Current wheeze at the age of 6 years was associated with worse lung function. Labeling wheezing in CF as \u201cCF-Asthma\u201d is misleading since the determinants are different, and may lead to inappropriate prescriptions of inhaled steroids.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.856840","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T06:15:02Z","timestamp":1652336102000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Prevalence and Determinants of Wheezing and Bronchodilatation in Children With Cystic Fibrosis: A Retrospective Cohort Study"],"prefix":"10.3389","volume":"10","author":[{"given":"Francois","family":"Galod\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ladipo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Andrieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Feghali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fayon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1002\/ppul.20294","article-title":"Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.","volume":"40","author":"Armstrong","year":"2005","journal-title":"Pediatr Pulmonol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.1164\/ajrccm.162.supplement_1.maic-3","article-title":"Clinical implications of inflammation in young children.","volume":"162","author":"Bush","year":"2000","journal-title":"Am J Respir Crit Care Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1136\/thx.2004.028340","article-title":"Structural changes to airway smooth muscle in cystic fibrosis.","volume":"60","author":"Hays","year":"2005","journal-title":"Thorax."},{"key":"B4","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1164\/rccm.200707-977OC","article-title":"Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis.","volume":"177","author":"Regamey","year":"2008","journal-title":"Am J Respir Crit Care Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1164\/ajrccm.149.3.8155167","article-title":"Guidelines for the evaluation of impairment\/disability in patients with asthma.","author":"Miller","year":"1994","journal-title":"Am J Respir Crit Care Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"77","DOI":"10.5694\/j.1326-5377.1980.tb76884.x","article-title":"Cystic fibrosis and bronchial hyperreactivity. 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