{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:47:46Z","timestamp":1790801266659,"version":"4.1.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>While heart rate variability (HRV) is a relevant non-invasive tool to assess the autonomic nervous system (ANS) functioning with recognized diagnostic and therapeutic implications, the lack of knowledge on its interest in neonatal medicine is certain. This review aims to briefly describe the algorithms used to decompose variations in the length of the RR interval and better understand the physiological autonomic maturation data of the newborn. Assessing newborns\u2019 autonomous reactivity can identify dysautonomia situations and discriminate children with a high risk of life-threatening events, which should benefit from cardiorespiratory monitoring at home. Targeted monitoring of HRV should provide an objective reflection of the newborn\u2019s intrinsic capacity for cardiorespiratory self-regulation.<\/jats:p>","DOI":"10.3389\/fped.2022.860145","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T06:37:34Z","timestamp":1650523054000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Heart Rate Variability Analysis to Evaluate Autonomic Nervous System Maturation in Neonates: An Expert Opinion"],"prefix":"10.3389","volume":"10","author":[{"given":"Hugues","family":"Patural","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pichot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Giraud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s12017-008-8034-1","article-title":"Autonomic control of the aging heart.","volume":"10","author":"Kaye","year":"2008","journal-title":"Neuromolecular Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S0929-693X(08)71851-7","article-title":"Normal and changed heart rate maturation of the neonate.","volume":"15","author":"Patural","year":"2008","journal-title":"Arch Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1203\/01.PDR.0000088074.97781.4F","article-title":"Sample asymmetry analysis of heart rate characteristics with application to neonatal sepsis and systemic inflammatory response syndrome.","volume":"54","author":"Kovatchev","year":"2003","journal-title":"Pediatr Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.clp.2010.06.002","article-title":"Heart rate characteristics: physiomarkers for detection of late-onset neonatal sepsis.","volume":"37","author":"Fairchild","year":"2010","journal-title":"Clin Perinatol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.autneu.2011.03.003","article-title":"Autonomic dysfunction in 2009 pandemic influenza A (H1N1) virus-related infection: a pediatric comparative study.","volume":"162","author":"Matt\u00e9i","year":"2011","journal-title":"Auton Neurosci."},{"key":"B6","first-page":"638","article-title":"Vagus nerve stimulation: a new approach to reduce heart failure.","volume":"17","author":"Klein","year":"2010","journal-title":"Cardiol J."},{"key":"B7","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin.","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature."},{"key":"B8","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1002\/aur.1929","article-title":"Diminished respiratory sinus arrhythmia response in infants later diagnosed with autism spectrum disorder.","volume":"11","author":"McCormick","year":"2018","journal-title":"Autism Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.earlhumdev.2005.03.015","article-title":"Short term heart rate variability in healthy neonates: normative data and physiological observations.","volume":"81","author":"Longin","year":"2005","journal-title":"Early Hum Dev."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2019.e01300","article-title":"Autonomic maturation from birth to 2 years: normative values.","volume":"5","author":"Patural","year":"2019","journal-title":"Heliyon."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1161\/01.cir.93.5.1043","article-title":"Heart rate variability. 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