{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:19:50Z","timestamp":1780503590250,"version":"3.54.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T00:00:00Z","timestamp":1649203200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this case report, we describe an extended-spectrum beta-lactamase (ESBL) \u2013 <jats:italic>Escherichia coli (E. coli)<\/jats:italic> strain of sequence type (ST) 1193, a novel, virulent, multidrug-resistant (MDR) clone with a rapid global spread. ST 1193 has been more commonly associated with invasive disease than other ESBL-<jats:italic>E. coli<\/jats:italic> STs. To our knowledge, this is the first known case in Sweden where a newborn died of an ESBL-<jats:italic>E. coli<\/jats:italic> ST 1193 meningitis. We emphasize that the clinical knowledge about the properties of certain MDR-clones should be increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A moderately preterm boy was born after preterm prolonged rupture of membranes. The mother had an ESBL-<jats:italic>E. coli<\/jats:italic> urinary tract infection during pregnancy. At 36 h of age he developed signs of infection and was given first-line therapy for early onset sepsis. Thereafter he developed seizures. The treatment was changed to cover suspected meningitis. Culture showed growth of the same ESBL- <jats:italic>E. coli<\/jats:italic> ST 1193 strain in the child\u2019s blood and cerebrospinal fluid, as well as in the mother\u2019s urine. Antibiotics were adapted. His condition deteriorated and he developed fulminant septic shock with treatment-resistant seizures. The boy passed away at 3 days of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This case highlights the risk of delay in diagnosis when a marking for carriage of MDR-bacteria is falsely removed from a medical record of a pregnant women. Further, it demonstrates that ESBL-<jats:italic>E. coli<\/jats:italic> ST 1193 infection in neonates can be fatal. Thus, studies regarding virulence factors of ESBL-<jats:italic>E. coli<\/jats:italic> infections in pregnant women and their children are needed to understand the association between this infection and severe invasive disease in newborn children.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.866762","type":"journal-article","created":{"date-parts":[[2022,4,6]],"date-time":"2022-04-06T06:10:23Z","timestamp":1649225423000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case Report: Fatal Outcome for a Preterm Newborn With Meningitis Caused by Extended-Spectrum \u03b2-Lactamase-Producing Escherichia coli Sequence Type 1193"],"prefix":"10.3389","volume":"10","author":[{"given":"Frida","family":"Oldendorff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Linn\u00e9r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Finder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Eisenlauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Kjellberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian 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