{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:48:01Z","timestamp":1778593681505,"version":"3.51.4"},"reference-count":102,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T00:00:00Z","timestamp":1654214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Kidney transplantation (KT) is currently the elective approach for patients with end-stage renal disease. Although it is a safe choice for these patients, the early complications can lead to graft dysfunction. One of the most redoubtable complications is delayed graft function (DGF), having no specific treatment. The effects of DGF on the graft survival are large enough to justify the formulation of specific biological protocols. Therefore, discovering biomarkers of acute impairment in renal transplanted patients is required. Creatinine is a poor marker to establish the kidney injury. Estimated glomerular filtration rate together with creatinine is ready to approximately measure the kidney function. Different serum and urine proteins are being studied as possible predictive biomarkers for delayed graft function. This review will concentrate on recent and existing research which provide insight concerning the contribution of some molecules for the estimation and evaluation of graft function after kidney transplantation. Further studies examining various aspects of DGF after KT are urgently needed to address a hitherto less-known clinical question.<\/jats:p>","DOI":"10.3389\/fped.2022.869628","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T08:31:07Z","timestamp":1654245067000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft"],"prefix":"10.3389","volume":"10","author":[{"given":"Paul Luchian","family":"Aldea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreea Liana","family":"Rachisan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan Ioan","family":"Stanciu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrei","family":"Picos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina Monica","family":"Picos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan Ioan","family":"Delean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramona","family":"Stroescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena Iuliana","family":"Starcea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina Maria","family":"Borzan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin Ioan","family":"Elec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2279","DOI":"10.1111\/j.1600-6143.2010.03179.x","article-title":"A risk prediction model for delayed graft function in the current era of deceased donor renal transplantation","volume":"10","author":"Irish","year":"2010","journal-title":"Am J Transplant."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/ajt.13195","article-title":"OPTN\/SRTR. 2013 annual data report: kidney","volume":"15","author":"Matas","year":"2015","journal-title":"Am J Transplant."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2995","DOI":"10.1093\/ndt\/gfn158","article-title":"Marked variation in the definition and diagnosis of delayed graft function: a systematic review","volume":"23","author":"Yarlagadda","year":"2008","journal-title":"Nephrol Dial Transplant."},{"key":"B4","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1590\/2175-8239-jbn-2018-0065","article-title":"Long-term effects of delayed graft function duration on function and survival of deceased donor kidney transplants","volume":"41","author":"Helfer","year":"2019","journal-title":"J Bras Nefrol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/tri.12696","article-title":"Predictors and outcomes of delayed graft function after living-donor kidney transplantation","volume":"29","author":"Redfield","year":"2015","journal-title":"Transplant Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.1093\/ndt\/gfp428","article-title":"Creatinine as the gold standard for kidney injury biomarker studies?","volume":"24","author":"Waikar","year":"2009","journal-title":"Nephrol Dial Transplant."},{"key":"B7","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3389\/fmed.2018.00358","article-title":"Non-invasive biomarkers of acute rejection in kidney transplantation: novel targets and strategies","volume":"5","author":"Eikmans","year":"2019","journal-title":"Front Med."},{"key":"B8","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1681\/ASN.2017010004","article-title":"Precision transplant medicine: biomarkers to the rescue","volume":"29","author":"Naesens","year":"2018","journal-title":"J Am Soc Nephrol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"11684","DOI":"10.1038\/srep11684","article-title":"Biomarkers of delayed graft function as a form of acute kidney injury in kidney transplantation","volume":"5","author":"Malyszko","year":"2015","journal-title":"Sci Rep."},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-44942-7.00216-8","author":"Di Somma","year":"2019","journal-title":"Diagnosis and Management of Acute Kidney Injury in the Emergency Department"},{"key":"B11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/B978-0-323-52978-5.00002-1","volume-title":"Measurement and Estimation of Kidney Function Fourth Edit. 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