{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:18Z","timestamp":1753891878953,"version":"3.41.2"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Vertical transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is a highly debated topic in the current pandemic situation. Early neonatal SARS-CoV-2 infection is rare and generally mild. Long-term data describing symptoms after COVID-19 in premature neonates is scarce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Presentation<\/jats:title><jats:p>Two premature, monoamniotic neonates were born by cesarean section to a mother 5 days after onset of symptomatic COVID-19. On day three of life both neonates developed hyperthermia, respiratory distress, and hematological changes, of which neutropenia persisted for over 40 days. Nasopharyngeal swabs for SARS-CoV-2 turned positive four days after delivery although the neonates were strictly isolated. Both neonates showed nearly identical time courses of ct values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our case report revealed prolonged low absolute neutrophil counts in two preterm neonates with symptomatic SARS-CoV-2 infection that is reasonably assumed to have been transmitted vertically <jats:italic>in utero<\/jats:italic>. After preterm delivery to a SARS-CoV-2 positive mother, testing for SARS-CoV-2 infection in neonates is crucial. Both neutropenia and lymphopenia should alert physicians to test for SARS-CoV-2 infection and also to follow the case.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.877954","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T13:04:51Z","timestamp":1650891891000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: Prolonged Neutropenia in Premature Monoamniotic Twins With SARS-CoV-2 Infection Acquired by Vertical Transmission"],"prefix":"10.3389","volume":"10","author":[{"given":"Anna S.","family":"Scholz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Wallwiener","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"P\u00f6schl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navina","family":"Kuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1001\/jamapediatrics.2020.0878","article-title":"Neonatal early-onset infection with SARS-CoV-2 in 33 neonates born to mothers with COVID-19 in Wuhan, China.","volume":"174","author":"Zeng","year":"2020","journal-title":"JAMA Pediatr."},{"key":"B2","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18933-4","article-title":"Analysis of SARS-CoV-2 vertical transmission during pregnancy.","volume":"11","author":"Fenizia","year":"2020","journal-title":"Nat Commun."},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2020-015065","article-title":"Neonates born to mothers with COVID-19: data from the Spanish society of neonatology registry.","volume":"147","author":"Sanchez-Luna","year":"2021","journal-title":"Pediatrics."},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-17436-6","article-title":"Transplacental transmission of SARS-CoV-2 infection.","volume":"11","author":"Vivanti","year":"2020","journal-title":"Nat Commun."},{"key":"B5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ajog.2020.07.049","article-title":"Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis.","volume":"224","author":"Kotlyar","year":"2021","journal-title":"Am J Obstet Gynecol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S2352-4642(20)30342-4","article-title":"Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance.","volume":"5","author":"Gale","year":"2021","journal-title":"Lancet Child Adolesc Health."},{"key":"B7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.anpede.2021.05.005","article-title":"SARS-CoV-2 and prematurity. 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