{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T22:36:12Z","timestamp":1785796572144,"version":"3.56.0"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study explored the status of serum vitamin D in hospitalized full-term neonates at a tertiary hospital in eastern China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective study was conducted among 471 hospitalized full-term neonates at the Children's Hospital of Soochow University between January 1 and June 20, 2020. Perinatal clinical data, serum 25-hydroxyvitamin D (25(OH)D<jats:sub>3<\/jats:sub>), laboratory examinations, serum calcium levels, and immune function were obtained and analyzed. We explored and analyzed the risk factors for vitamin D insufficiency or deficiency, and we also attempted to determine correlations between vitamin D and its influence on immunity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean serum 25(OH)D<jats:sub>3<\/jats:sub> was 33.65\u00b16.07ng\/ml.The prevalence of vitamin D insufficiency was 28.24%,vitamin D sufficiency was 71.76%, there was no vitamin D deficiency. The serum 25-(OH)D<jats:sub>3<\/jats:sub> in singleton neonate was higher than twins or multiple infants (<jats:italic>t<\/jats:italic> = \u221210.918, <jats:italic>P<\/jats:italic> = 0.000). The serum 25-(OH)D<jats:sub>3<\/jats:sub> were higher in neonates who born in spring and summer than in winter (H = 13.443, <jats:italic>P<\/jats:italic> = 0.001). The serum 25-(OH)D<jats:sub>3<\/jats:sub> in appropriate for gestational age (AGA) and large for gestational age (LGA) neonates were higher than small for gestational age (SGA) (H = 7.686, <jats:italic>P<\/jats:italic> = 0.021). The serum 25-(OH)D<jats:sub>3<\/jats:sub> were higher in neonates whose mothers had no underlying diseases than those with certain immunological and infectious diseases (F = 12.417, <jats:italic>P<\/jats:italic> = 0.000). The serum 25-(OH)D<jats:sub>3<\/jats:sub> in neonates whose mothers had none or one perinatal complication were higher than those with two or more (F = 13.299, <jats:italic>P<\/jats:italic> = 0.000). The neonates with eosinophils \u22645% or normal platelet counts or serum Ca<jats:sup>++<\/jats:sup> \u22650.9 mmol\/L have higher serum 25-(OH)D<jats:sub>3<\/jats:sub>. Neonates born in winter were at risk for vitamin D insufficiency, and the incidence of infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia in the vitamin D insufficiency group were higher than sufficiency group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The serum CD3+, CD3+CD4+, and IgA levels in vitamin D sufficiency neonates were significantly higher than those in insufficiency group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of vitamin D insufficiency was 28.24%, and birth in winter was a risk factor for vitamin D insufficiency in hospitalized full-term neonates in Suzhou area. Neonates with infectious pneumonia, sepsis, cytomegalovirus infection, and hypocalcemia exhibited a high risk of vitamin D insufficiency. The serum CD3<jats:sup>+<\/jats:sup>, CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup>, and IgA levels in neonates with vitamin D insufficiency were lower.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.878992","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T15:44:57Z","timestamp":1654098297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Serum Vitamin D Insufficiency in Hospitalized Full-Term Neonates at a Tertiary Hospital in Eastern China"],"prefix":"10.3389","volume":"10","author":[{"given":"Huawei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1210\/jc.81.3.1129","article-title":"Healthy elderly French women living at home have secondary hyperparathyroidism and high bone turnover in winter. 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