{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:43:33Z","timestamp":1785825813029,"version":"3.56.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Neonatal death is the major problem in developing world. Burden and predictors of neonatal mortality vary across countries and even among regions of a country, so understanding the problem concerning these factors is essential to overcome the problem. Therefore, this study aimed to determine time to death and its predictors of neonatal mortality among neonates who were admitted to the neonatal intensive care unit of Tertiary Hospital, Addis Ababa, Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A hospital-based retrospective cohort study was employed among 434 neonates admitted in Tertiary hospital, Addis Ababa, Ethiopia. A Kaplan Meier curve and a log-rank test were used to estimate the survival time and compare survival curves between variables. The cox proportional hazard model was also fitted to identify predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 434 neonates included in the study, 11.1% of which were died, and the incidence rate was 19.2 per 1000 live births. The time to death of neonates was 17 days. Independent predictors of neonatal mortality were incomplete maternal antenatal follow up[AHR: 3.7 (95% CI:1.86,7.60)], low(Appearance, Pulse, Grimily, Activity, and Respiration(APGAR)score[AHR:5.0 (95%CI:1.51\u201315.04)], perinatal asphyxia [AHR:5.2 (95%CI:1.92\u201314.30)], preterm 4.2 (95%CI: 1.32\u20138.83)]. Moreover, small for gestational age [AHR:4.8 (95%CI:2.33\u20139.72)], respiratory distress[AHR: 2.5 (95%CI: 1.24\u20135.09)], sepsis [AHR: 3.4 (95%CI: 1.71\u20134.01)], low birth weight[AHR: 7.3 (95%CI:2.69,1.91)], and tracheoesophageal fistula [AHR: 2.2 (95%CI: 1.13\u20134.32)].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The overall incidence rate was 19.2 deaths per 1,000 live births. Emphasis should be given to incomplete Antenatal care follow up, small for gestation, preterm, low birth weight, low 5<jats:sup>th<\/jats:sup> min APGAR score, neonatal sepsis, respiratory distress, perinatal asphyxia, and tracheoesophageal fistula.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.913583","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T05:10:55Z","timestamp":1661749855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["Time to death and its predictors among neonates who were admitted to the neonatal intensive care unit at tertiary hospital, Addis Ababa, Ethiopia: Retrospective follow up study"],"prefix":"10.3389","volume":"10","author":[{"given":"Mulat Mossie","family":"Menalu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bereket","family":"Gebremichael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalkidan Wondwossen","family":"Desta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Worku Misganaw","family":"Kebede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fetene Nigussie","family":"Tarekegn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getaneh Baye","family":"Mulu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bantalem Tilaye","family":"Atinafu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"B1","unstructured":"Neonatal Mortality2021"},{"key":"B2","volume-title":"Levels & Trends in Child Mortality","year":"2018"},{"key":"B3","volume-title":"Newborns: Reducing Mortality","year":"2018"},{"key":"B4","unstructured":"The global health observationChild mortality and cause of death"},{"key":"B5","unstructured":"Children in Africa: Key Statistics on Child Survival and Population"},{"key":"B6","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/s12978-016-0119-y","article-title":"The neonatal mortality and its determinants in rural communities of Eastern Uganda","volume":"13","author":"Kananura","year":"2016","journal-title":"Reprod Health."},{"key":"B7","volume-title":"Newborn Mortality","year":"2022"},{"key":"B8","volume-title":"Committing to Child Survival: A Promise Renewed","year":"2015"},{"key":"B9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1186\/1471-2458-14-521","article-title":"Determinants of neonatal mortality in Nigeria: evidence from the 2008 demographic and health survey","volume":"14","author":"Ezeh","year":"2014","journal-title":"BMC Public Health."},{"key":"B10","unstructured":"WORLDDATA ATLAS ETHIOPIA HEALTH,. Ethiopia Neonatal Mortality Rate, 1960\u20132021.\n          2020"},{"key":"B11","doi-asserted-by":"publisher","first-page":"55","DOI":"10.4314\/ejhs.v24i0.6S","article-title":"A meta-analysis of selected maternal and fetal factors for perinatal mortality","volume":"24","author":"Berhan","year":"2014","journal-title":"Ethiopian J Health Sci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1186\/1471-2458-13-483","article-title":"Neonatal mortality in Ethiopia: trends and determinants","volume":"13","author":"Mekonnen","year":"2013","journal-title":"BMC Public Health."},{"key":"B13","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/1471-2458-13-168","article-title":"Predictors of perinatal mortality in rural population of Northwest Ethiopia: a prospective longitudinal study","volume":"13","author":"Andargie","year":"2013","journal-title":"BMC Public Health."},{"key":"B14","volume-title":"Maternal and Newborn Health Disparities Ethiopia","year":"2015"},{"key":"B15","article-title":"Central Statistical Agency (CSA)","year":"2016"},{"key":"B16","unstructured":"National Newborn and Child Survival Strategy Document Brief Summary 2015\/16-2019\/20"},{"key":"B17","unstructured":"2010"},{"key":"B18","doi-asserted-by":"publisher","first-page":"715","DOI":"10.4314\/ahs.v20i2.23","article-title":"Determinants of neonatal mortality in Ethiopia: an analysis of the 2016 Ethiopia Demographic and Health Survey","volume":"20","author":"Basha","year":"2020","journal-title":"Afr Health Sci."},{"key":"B19","first-page":"p. 1","volume-title":"Population Size by Age and Sex","year":"2008"},{"key":"B20","volume-title":"Addis Ababa University","year":""},{"key":"B21","unstructured":"2006"},{"key":"B22","doi-asserted-by":"publisher","first-page":"57","DOI":"10.2147\/PHMT.S130309","article-title":"Patterns of admission and factors associated with neonatal mortality among neonates admitted to the neonatal intensive care unit of University of Gondar Hospital, Northwest Ethiopia","volume":"8","author":"Demisse","year":"2017","journal-title":"Pediatr Health, Med Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1111\/papr.12108","article-title":"Recent management advances in acute postoperative pain","volume":"14","author":"Argoff","year":"2014","journal-title":"Pain Pract."},{"key":"B24","article-title":"Central Statistical Agency (CSA)[Ethiopia] and ICF","volume-title":"Ethiopia Demographic and Health Survey, Addis Ababa.","year":"2016"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-016-0994-9","article-title":"Survival of neonates and predictors of their mortality in Tigray region, Northern Ethiopia: prospective cohort study","volume":"16","author":"Mengesha","year":"2016","journal-title":"BMC Pregnancy Childbirth."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-019-2227-5","article-title":"Predictors of neonatal mortality in neonatal intensive care unit at referral hospital in Southern Ethiopia: a retrospective cohort study","volume":"19","author":"Orsido","year":"2019","journal-title":"BMC Pregnancy Childbirth."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12887-019-1907-7","article-title":"Neonatal survival and determinants of mortality in Aroresa district, southern Ethiopia: a prospective cohort study","volume":"20","author":"Limaso","year":"2020","journal-title":"BMC Pediatr."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13052-017-0369-5","article-title":"A cohort analysis of neonatal hospital mortality rate and predictors of neonatal mortality in a sub-urban hospital of Cameroon","volume":"43","author":"Ndombo","year":"2017","journal-title":"Ital J Pediatr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"e0203314","DOI":"10.1371\/journal.pone.0203314","article-title":"Trends of admission and predictors of neonatal mortality: a hospital based retrospective cohort study in Somali region of Ethiopia","volume":"13","author":"Elmi Farah","year":"2018","journal-title":"PLoS ONE."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4172\/2161-0665.1000352","article-title":"Predictors of neonatal mortality among neonates who admitted in neonatal intensive care unit at Arba Minch General Hospital","volume":"33","author":"Dessu","year":"2019","journal-title":"Ethiopian J Health Dev"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e0245065","DOI":"10.1371\/journal.pone.0245065","article-title":"Timing and causes of neonatal mortality in Tamale Teaching Hospital, Ghana: a retrospective study","volume":"16","author":"Abdul-Mumin","year":"2021","journal-title":"PloS ONE"},{"key":"B32","doi-asserted-by":"publisher","first-page":"369","DOI":"10.4314\/ahs.v18i2.22","article-title":"Neonatal mortality at the neonatal unit: the situation at a teaching hospital in Ghana","volume":"18","author":"Owusu","year":"2018","journal-title":"Afr Health Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0140-6736(13)60993-9","article-title":"Mortality risk in preterm and small-for-gestational-age infants in low-income and middle-income countries: a pooled country analysis","volume":"382","author":"Katz","year":"2013","journal-title":"Lancet."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e20171881","DOI":"10.1542\/peds.2017-1881","article-title":"Mortality in infants affected by preterm birth and severe small-for-gestational age birth weight","volume":"140","author":"Ray","year":"2017","journal-title":"Pediatrics."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12887-020-02051-7","article-title":"Cause and predictors of neonatal mortality among neonates admitted to neonatal intensive care units of public hospitals in eastern Ethiopia: a facility-based prospective follow-up study","volume":"20","author":"Desalew","year":"2020","journal-title":"BMC Pediatr."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12884-014-0389-8","article-title":"A case-control study of risk factors for fetal and early neonatal deaths in a tertiary hospital in Kenya","volume":"14","author":"Yego","year":"2014","journal-title":"BMC Pregnancy Childbirth."},{"key":"B37","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12884-020-03533-3","article-title":"Apgar score and neonatal mortality in China: an observational study from a national surveillance system","volume":"21","author":"Mu","year":"2021","journal-title":"BMC Pregnancy Childbirth."},{"key":"B38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1056\/NEJMoa1915075","article-title":"Apgar score and risk of neonatal death among preterm infants","volume":"383","author":"Cnattingius","year":"2020","journal-title":"N Engl J Med."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12889-016-3979-8","article-title":"Cause of neonatal deaths in Northern Ethiopia: a prospective cohort study","volume":"17","author":"Mengesha","year":"2017","journal-title":"BMC Public Health."},{"key":"B40","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.2147\/JMDH.S366470","article-title":"Time to death and predictors among neonates with esophageal atresia in Ethiopia","volume":"15","author":"Misganaw","year":"2022","journal-title":"J Multidiscip Healthc."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.913583\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T13:06:31Z","timestamp":1662037591000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.913583\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,29]]},"references-count":40,"alternative-id":["10.3389\/fped.2022.913583"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.913583","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,29]]},"article-number":"913583"}}