{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:48:23Z","timestamp":1760986103713,"version":"3.41.2"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T00:00:00Z","timestamp":1657670400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Vitamin D deficiency is prevalent in pediatric patients presenting for hematopoietic stem cell transplantation (HSCT) and has been linked to poor clinical outcomes. Using the data from a randomized control trial, in this paper we explore the effects of vitamin D supplementation on circulating cytokine levels during pediatric HSCT (<jats:ext-link>www.clinicaltrials.gov<\/jats:ext-link> as NCT03176849). A total of 41 children, 20 received Stoss therapy and 21 children received standard of care vitamin D supplementation. Levels of 25(OH)D and 20 cytokines were assessed at baseline and day +30. Significantly (<jats:italic>P<\/jats:italic> &amp;lt; 0.05) higher levels of mostly proinflammatory cytokines, FGF, GCSF, TNF\u03b1, IL-2, IL-6, IP10 were detected pre-transplant for patients with low compared to those with normal vitamin D levels. In sex stratified models that compare changes in cytokines between Stoss vs. standard of care, females in the Stoss group show greater changes in mostly pro -inflammatory cytokines- IP-10 (<jats:italic>P<\/jats:italic> = 0.0047), MIG (<jats:italic>P<\/jats:italic> = 0.009), and RANTES (<jats:italic>P<\/jats:italic> = 0.0047), IL-2R (<jats:italic>P<\/jats:italic> = 0.07) and IL-6(<jats:italic>P<\/jats:italic> = 0.069). Despite a small sample size, these findings suggest vitamin D deficiency affects the pre-transplant cytokine milieu and higher doses of vitamin D (Stoss therapy) appears to influence proinflammatory cytokine responses in a sex specific manner during pediatric HSCT. Larger clinical trials are warranted to validate these results.<\/jats:p>","DOI":"10.3389\/fped.2022.913586","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T06:26:17Z","timestamp":1657693577000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Vitamin D Supplementation: Association With Serum Cytokines in Pediatric Hematopoietic Stem Cell 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