{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:47:33Z","timestamp":1762508853107,"version":"3.41.2"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To examine the predictive value of serum biomarkers combined with other indicators for necrotizing enterocolitis (NEC) surgery decision-making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical data, including baseline information, clinical features, imaging presentation and serum assessment, of the infants enrolled were collected, and the serum concentrations of HBD2, HMGB-1, Claudin-3 and Relm\u03b2 were determined. <jats:italic>Student's t test<\/jats:italic>, the <jats:italic>Mann\u2013Whitney U test<\/jats:italic>, the <jats:italic>chi-square test<\/jats:italic> and logistic regression analysis were used. Receiver operating characteristic (<jats:italic>ROC<\/jats:italic>) curves were also generated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty-nine infants were enrolled, with 23 in the surgical NEC group and 26 in the medical NEC group. There were no differences in the baseline clinical information, including birth weight, gestational age, admission age and risk factors, during pregnancy and before enrollment (<jats:italic>P<\/jats:italic> &amp;gt; 0.05). Peritonitis, intestinal adhesion and sepsis were more common in the surgical group (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The incidences of abdominal distention, abdominal wall tenseness, abdominal tenderness and absent bowel sounds in the surgical group were significantly higher when NEC occurred (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). There were no differences between the two groups in the imaging presentation (<jats:italic>P<\/jats:italic> &amp;gt; 0.05). The concentration of Relm\u03b2 {[8.66 (4.29, 19.28) <jats:italic>vs<\/jats:italic>. 20.65 (9.51, 44.65)]} in the surgical group was significantly higher (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Abdominal wall tenseness, abdominal tenderness and a Relm\u03b2 concentration &amp;gt; 19.7 \u03bcmol\/L were included in the predictive model, and the AUC of the predictive score was 0.943 (95% CI: 0.891\u20131.000) (<jats:italic>P<\/jats:italic> &amp;lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum Relm\u03b2 concentration combined with abdominal wall tenseness and abdominal tenderness may be useful in determining surgical timing in neonates with NEC.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.943320","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:03:26Z","timestamp":1662440606000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Serum Relm\u03b2 combined with abdominal signs may predict surgical timing in neonates with NEC: A cohort study"],"prefix":"10.3389","volume":"10","author":[{"given":"Xiao-Chen","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Ran","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Yu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Jie","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.jpeds.2019.01.048","article-title":"Association between policy changes for oxygen saturation alarm settings and neonatal morbidity and mortality in infants born very preterm","volume":"209","author":"Foglia","year":"2019","journal-title":"J Pediatr."},{"key":"B2","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jpeds.2020.05.040","article-title":"NEOCOSUR neonatal network. 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