{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:14:42Z","timestamp":1753892082963,"version":"3.41.2"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T00:00:00Z","timestamp":1656288000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Multisystem inflammatory syndrome in children (MIS-C) is a newly defined hyperinflammatory disease linked to antecedent coronavirus disease 2019. Patients with MIS-C present with various symptoms, and ocular findings such as mild bilateral conjunctivitis are relatively common. However, detailed descriptions of severe ocular reports associated with MIS-C are scarce in the current literature. Here we report a case of MIS-C in a Japanese boy, with severe eye manifestations in the form of anterior scleritis as the primary MIS-C symptom. Detailed ocular examinations by ophthalmologists may be key for clarifying the pathophysiology of MIS-C.<\/jats:p>","DOI":"10.3389\/fped.2022.943652","type":"journal-article","created":{"date-parts":[[2022,6,27]],"date-time":"2022-06-27T06:04:11Z","timestamp":1656309851000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Anterior Scleritis Presenting as a Primary Ocular Manifestation in Multisystem Inflammatory Syndrome in Children With COVID-19"],"prefix":"10.3389","volume":"10","author":[{"given":"Daisuke","family":"Matsubara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Kasuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Mizobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mami","family":"Hiwada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuru","family":"Seki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Yamagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1016\/S0140-6736(20)31103-X","article-title":"An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study","volume":"395","author":"Verdoni","year":"2020","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1056\/NEJMoa2021680","article-title":"Multisystem inflammatory syndrome in U.S. Children and adolescents","volume":"383","author":"Feldstein","year":"2020","journal-title":"N Engl J Med."},{"key":"B3","unstructured":"Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease 2019 (COVID-19)"},{"key":"B4","unstructured":"Multisystem Inflammatory Syndrome in Children and Adolescents With COVID-19"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1016\/S0140-6736(21)00579-1","article-title":"Anterior uveitis in paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2","volume":"397","author":"Wong Chung","year":"2021","journal-title":"Lancet."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e818","DOI":"10.1016\/S2665-9913(21)00272-1","article-title":"Bilateral anterior non-necrotising scleritis, anterior uveitis, and unilateral facial nerve palsy in paediatric inflammatory multisystem syndrome temporally associated with COVID-19","volume":"3","author":"Islam","year":"2021","journal-title":"Lancet Rheumatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1002\/jmv.27521","article-title":"Bilateral intermediate uveitis in a healthy teenager with the multisystem inflammatory syndrome in children secondary to COVID-19 infection","volume":"94","author":"Sim","year":"2022","journal-title":"J Med Virol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1080\/09273948.2021.1909070","article-title":"Bilateral acute anterior uveitis and corneal punctate epitheliopathy in children diagnosed with multisystem inflammatory syndrome secondary to COVID-19","volume":"29","author":"\u00d6zt\u00fcrk","year":"2021","journal-title":"Ocul Immunol Inflamm."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.4103\/ijo.IJO_52_21","article-title":"COVID-19 related multi-inflammatory syndrome presenting with uveitis - 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