{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:41:56Z","timestamp":1772836916469,"version":"3.50.1"},"reference-count":18,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Coronavirus disease 2019 (COVID-19) was first reported to the World Health Organization (WHO) in December 2019 and has since unleashed a global pandemic, with over 518 million cases as of May 10, 2022. Neonates represent a very small proportion of those patients. Among reported cases of neonates with symptomatic COVID-19 infection, the rates of hospitalization remain low. Most reported cases in infants and neonates are community acquired with mild symptoms, most commonly fever, rhinorrhea and cough. Very few require intensive care or invasive support for acute infection. We present a case of a 2-month-old former 26-week gestation infant with a birthweight of 915 grams and diagnoses of mild bronchopulmonary dysplasia and a small ventricular septal defect who developed acute respiratory decompensation due to COVID-19 infection. He required veno-arterial extracorporeal membrane oxygenation support for 23 days. Complications included liver and renal dysfunction and a head ultrasound notable for lentriculostriate vasculopathy, extra-axial space enlargement and patchy periventricular echogenicity. The patient was successfully decannulated to conventional mechanical ventilation with subsequent extubation to non-invasive respiratory support. He was discharged home at 6 months of age with supplemental oxygen <jats:italic>via<\/jats:italic> nasal cannula and gastrostomy tube feedings. He continues to receive outpatient developmental follow-up. To our knowledge, this is the first case report of a preterm infant during their initial hospitalization to survive ECMO for COVID-19.<\/jats:p>","DOI":"10.3389\/fped.2022.953122","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T06:47:54Z","timestamp":1660286874000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Extracorporeal membrane oxygenation in the care of a preterm infant with COVID-19 infection: Case report"],"prefix":"10.3389","volume":"10","author":[{"given":"Jessica","family":"Patrick-Esteve","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Mumphrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Masoumy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Lawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Hebert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Barkemeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/S1473-3099(20)30120-1","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2021","journal-title":"The Lancet Infect Dis."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3041","DOI":"10.1007\/s00431-021-04042-x","article-title":"Clinical characteristics of COVID-19 in neonates and young infants","volume":"180","author":"Spoulou","year":"2021","journal-title":"Eur J Pediatr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.arcmed.2022.03.001","article-title":"COVID-19 in neonates with positive RT-PCR Test","volume":"53","author":"Garcia","year":"2022","journal-title":"Systematic Review Arch Med Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1038\/s41372-020-0715-0","article-title":"The clinical course of SARS-CoV-2 positive neonates","volume":"40","author":"De Bernardo","year":"2020","journal-title":"J Perinatol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1097\/INF.0000000000002700","article-title":"COVID-19 in children, pregnancy and neonates: a review of epidemiologic and clinical features","volume":"39","author":"Zimmermann","year":"2020","journal-title":"Pediatr Infect Dis J"},{"key":"B6","unstructured":"2021"},{"key":"B7","unstructured":"2022"},{"key":"B8","unstructured":"Louisiana Hits Record COVID-19 Cases, Hospitalizations. Louisiana Department of Health\n            FacianeM\n          2021"},{"key":"B9","unstructured":"2022"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e2111182","DOI":"10.1001\/jamanetworkopen.2021.11182","article-title":"Underlying Medical conditions associated with severe COVID-19 illness among children","volume":"4","author":"Kompaniyets","year":"2021","journal-title":"JAMA Netw Open"},{"key":"B11","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1056\/NEJMoa2204399","article-title":"Maternal vaccination and risk of hospitalization for COVID-19 among infants","volume":"387","author":"Rankin","year":"2022","journal-title":"NEJM"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1542\/neo.22-1-e1","article-title":"Advancing health equity by translating lessons learned from NICU family visitations during the COVID-19 pandemic","volume":"22","author":"Peng","year":"2021","journal-title":"Neoreviews"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1038\/s41372-018-0206-8","article-title":"Lenticulostriate vasculopathy in preterm infants: a new classification, clinical associations and neurodevelopmental outcome","volume":"38","author":"Sisman","year":"2018","journal-title":"J Perinatol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.thromres.2021.07.011","article-title":"Thrombotic risk in children with COVID-19 infection: a systematic review of the literature","volume":"205","author":"Zaffanello","year":"2021","journal-title":"Thromb Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1097\/MAT.0000000000001422","article-title":"Extracorporeal Life Support Oxygenation for COVID-19: updated 2021 guidelines from the extracorporeal life support organization","volume":"67","author":"Bedulak","year":"2021","journal-title":"ASAIO J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1007\/s12055-021-01204-2","article-title":"Use of VA ECMO and percutaneous palliation of ductal dependent coarctation in a neonate with trisomy 21 and COVID-19 pneumonia","volume":"37","author":"Sainathan","year":"2021","journal-title":"Indian J Thorac Cardiovasc Surg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1017\/S1047951121002511","article-title":"COVID-19 and ECMO support after neonatal congenital heart surgery: a case report","volume":"32","author":"Cicek","year":"2022","journal-title":"Cardiol Young"},{"key":"B18","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1097\/MAT.0000000000001309","article-title":"Extracorporeal membrane oxygenation in children with coronavirus Disease 2019: preliminary report from the collaborative European chapter of the extracorporeal life support organization prospective survey","volume":"67","author":"Di Nardo","year":"2021","journal-title":"ASAIO J"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.953122\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T06:47:57Z","timestamp":1660286877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.953122\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,12]]},"references-count":18,"alternative-id":["10.3389\/fped.2022.953122"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.953122","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,12]]},"article-number":"953122"}}