{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T16:17:47Z","timestamp":1785341867739,"version":"3.55.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Globally, the incidence of necrotizing enterocolitis (NEC) varies between 6 and 15% of all neonates admitted to the neonatal intensive care unit (NICU). Though necrotizing enterocolitis is a multifactorial and life-threatening disease, low birth prematurity is the single cause. Therefore, determining the time to presentation and its predictors of necrotizing enterocolitis were the main goals of this investigation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>An institution-based retrospective follow-up study was conducted among 747 low birth weight (LBW) neonates admitted to the neonatal intensive care unit of Felege Hiwot comprehensive specialized Hospital from 1 January 2017 to 30 December 2019. The sample size was calculated by using the STATA package. Data were entered into Epi data version 3.1 and exported to STATA version 14 for analysis. The log-rank test and the Kaplan\u2013Meier estimator were used to display the survival probability and differences between groups. At a significance threshold of 5%, Cox proportional hazard regression was performed to determine the net independent predictors of necrotizing enterocolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>The overall incidence rate was 0.86 per 1,000 person-days (95% <jats:italic>CI<\/jats:italic>: 0.67, 1.14) with a 6.8% (95% i: 5.2, 8.9) proportion of necrotizing enterocolitis among low birth weight neonates. Preeclampsia [adjusted hazard ratio (<jats:italic>AHR<\/jats:italic>);1.92 (95% CI: 1.03\u20133.58)], premature rapture of membrane [<jats:italic>AHR<\/jats:italic>; 2.36 (95%, <jats:italic>CI<\/jats:italic>: 1.19\u20134.69)], perinatal asphyxia [<jats:italic>AHR<\/jats:italic>; 4.05 (95%, <jats:italic>CI<\/jats:italic>: 2.04\u20138.60)], gestational age between 28 and 32 weeks [<jats:italic>AHR<\/jats:italic>; 3.59 (95% <jats:italic>CI<\/jats:italic>: 1.01\u20138.83)], and birth weigh less than 1,000 g [<jats:italic>AHR<\/jats:italic>; 5.45 (95% <jats:italic>CI<\/jats:italic>: 3.84\u20139.12) were the independent predictors of necrotizing enterocolitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Within the first 1\u20137 days of a newborn\u2019s life, necrotizing enterocolitis was most common. It was discovered that preeclampsia, premature rupture of membrane, perinatal asphyxia, gestational age of 28\u201332 weeks, and birth weight less than 1,000 g were predictors of its occurrence.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.959631","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T05:44:06Z","timestamp":1662961446000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Time to occurrence of necrotizing enterocolitis and its predictors among low birth weight neonates admitted at neonatal intensive care unit of felege hiwot compressive specialized hospital BahirDar, Ethiopia, 2021: A retrospective follow-up study"],"prefix":"10.3389","volume":"10","author":[{"given":"Tamiru","family":"Alene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulualem Gete","family":"Feleke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Addisu","family":"Yeshambel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham Tsedalu","family":"Amare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agimasie","family":"Tigabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tekalign Amera","family":"Birlie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yared Asmare","family":"Aynalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gashaw","family":"Kerebeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirubel","family":"Eshetu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilahun Degu","family":"Tsega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biresaw","family":"Wassihun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Getachew Asmare","family":"Adella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfaye Yitna","family":"Chichiabellu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1542\/pir.2017-0002","article-title":"Necrotizing enterocolitis.","volume":"38","author":"Rich","year":"2017","journal-title":"Pediatr Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00383-010-2583-8","article-title":"Long-term outcome of surgically managed necrotizing enterocolitis in a developing country.","volume":"26","author":"Arnold","year":"2010","journal-title":"Pediatr Surg Int."},{"key":"B3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1056\/NEJMoa1403489","article-title":"Causes and timing of death in extremely premature infants from 2000 through 2011.","volume":"372","author":"Patel","year":"2015","journal-title":"N Engl J Med."},{"key":"B4","author":"Tooley","year":"2003","journal-title":"Intensive care nursery HOUSE STAFF MANUAL the Regents of the University of California"},{"key":"B5","author":"Caplan","year":"2016","journal-title":"Second Annual Neonatal Scientific Workshop at the EMA Report."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/s12887-020-02231-5","article-title":"Global incidence of necrotizing enterocolitis: A systematic review and meta-analysis.","volume":"20","author":"Alsaied","year":"2020","journal-title":"BMC Pediatr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1016\/B978-0-323-07255-7.00094-5","author":"Sylvester","year":"2012","journal-title":"Necrotizing enterocolitis. 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