{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T14:00:11Z","timestamp":1782396011307,"version":"3.54.5"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T00:00:00Z","timestamp":1665619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This review aimed to assess if monochorionic twin pregnancies conceived by assisted conception have worse maternal and neonatal outcomes as compared to those conceived naturally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Datasets of PubMed, ScienceDirect, CENTRAL, Embase, and Google Scholar were searched for studies comparing maternal and neonatal outcomes of monochorionic twin pregnancies conceived by assisted vs. spontaneous methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight studies comparing 337 assisted with 2,711 spontaneously conceived monochorionic twin pregnancies were included. Meta-analysis revealed that the mode of conception of monochorionic twin pregnancies had no impact on the risk of hypertensive disorders of pregnancy (HDP) (OR: 1.36 95% CI, 0.73, 2.54 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20099% <jats:italic>p<\/jats:italic>\u2009=\u20090.03), twin-twin transfusion syndrome (TTTS) (OR: 0.83 95% CI, 0.52, 1.31 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090% <jats:italic>p<\/jats:italic>\u2009=\u20090.42), and very preterm delivery (OR: 1.18 95% CI, 0.74, 1.88 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200941% <jats:italic>p<\/jats:italic>\u2009=\u20090.49). We noted no statistically significant difference in the mean birth weights (MD: \u221217.66 95% CI, \u2212157.23, 121.91 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200982% <jats:italic>p<\/jats:italic>\u2009=\u20090.80), risk of intra-uterine death (OR: 0.90 95% CI, 0.51, 1.60 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200936% <jats:italic>p<\/jats:italic>\u2009=\u20090.73) and small for gestational age between the two groups (OR: 0.92 95% CI, 0.67, 1.26 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090% <jats:italic>p<\/jats:italic>\u2009=\u20090.59). There was an increased risk of caesarean sections (OR: 1.34 95% CI, 1.00, 1.80 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u20090% <jats:italic>p<\/jats:italic>\u2009=\u20090.05) and neonatal death with assisted conceptions as compared to spontaneous conceptions (OR: 2.35 95% CI, 1.11, 5.01 <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200937% <jats:italic>p<\/jats:italic>\u2009=\u20090.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Monochorionic twin pregnancies conceived <jats:italic>via<\/jats:italic> assisted reproductive technology have a heightened risk of cesarean section and neonatal deaths. However, there is a need for further studies to supplement current evidence.<\/jats:p><jats:p><jats:bold>Systematic Review Registration:<\/jats:bold><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?RecordID=325133<\/jats:ext-link>, identifier: CRD42022325133.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.962190","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T11:55:43Z","timestamp":1665662143000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparison of outcomes of monochorionic twin pregnancies conceived by assisted reproductive technology vs. spontaneous conceptions: A systematic review and 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