{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:44:01Z","timestamp":1767912241842,"version":"3.49.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Despite recent progress in caring for patients born with esophageal atresia (EA), undernutrition and stunting remain common. Our study objective was to assess nutritional status in the first year after birth with EA and to identify factors associated with growth failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>We conducted a population-based study of all infants born in France with EA between 2010 and 2016. Through the national EA register, we collected prenatal to 1 year follow-up data. We used body mass index and length-for-age ratio Z scores to define patients who were undernourished and stunted, respectively. Factors with <jats:italic>P<\/jats:italic> &amp;lt; 0.20 in univariate analyses were retained in a logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 1,154 patients born with EA, body mass index and length-for-age ratio Z scores at 1 year were available for about 61%. Among these, 15.2% were undernourished and 19% were stunted at the age of 1 year. There was no significant catch-up between ages 6 months and 1 year. Patients born preterm (41%), small for gestational age (17%), or with associated abnormalities (55%) were at higher risk of undernutrition and stunting at age 1 year (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). Neither EA type nor surgical treatment was associated with growth failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Undernutrition and stunting are common during the first year after birth in patients born with EA. These outcomes are significantly influenced by early factors, regardless of EA type or surgical management. Identifying high-risk patient groups with EA (i.e., those born preterm, small for gestational age, and\/or with associated abnormalities) may guide early nutritional support strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.969617","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T13:45:52Z","timestamp":1659620752000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Nutritional status at age 1 year in patients born with esophageal atresia: A population-based, prospective cohort study"],"prefix":"10.3389","volume":"10","author":[{"given":"Suzanne","family":"Depoortere","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Lapillonne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rony","family":"Sfeir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaud","family":"Bonnard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gelas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta","family":"Panait","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Yves","family":"Rabattu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Guignot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lamireau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Irtan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Habonimana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Breton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Fouquet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossein","family":"Allal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Elbaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Talon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Ranke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Abely","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Luc","family":"Michel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9phine","family":"Lirussi Borgnon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Buisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hubert","family":"Lardy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Petit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Chaussy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinne","family":"Borderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Levard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Cremillieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Tolg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Breaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Jaby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Grossos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philine","family":"De Vries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Arnould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Pelatan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Geiss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Laplace","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u00e9va","family":"Kyheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Nicolas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Aumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Gottrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jpeds.2021.02.064","article-title":"Risk factors of early mortality and morbidity in esophageal atresia with distal tracheoesophageal fistula: a population-based cohort study","volume":"234","author":"Sfeir","year":"2021","journal-title":"J Pediatr"},{"key":"B2","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1097\/MPG.0000000000001401","article-title":"ESPGHAN-NASPGHAN guidelines for the evaluation and treatment of gastrointestinal and nutritional complications in children with esophageal atresia-tracheoesophageal fistula","volume":"63","author":"Krishnan","year":"2016","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.prrv.2015.11.005","article-title":"Motility, digestive and nutritional problems in esophageal atresia","volume":"19","author":"Gottrand","year":"2016","journal-title":"Paediatr Respir Rev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1053\/jpsu.2001.22299","article-title":"Experiences of a parent support group with the long-term consequences of esophageal atresia","volume":"36","author":"Schier","year":"2001","journal-title":"J Pediatr Surg."},{"key":"B5","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s13023-014-0206-5","article-title":"Results from the French national esophageal atresia register: one-year outcome","volume":"9","author":"Schneider","year":"2014","journal-title":"Orphanet J Rare Dis."},{"key":"B6","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1055\/s-0030-1249610","article-title":"Early and long term outcome in children with esophageal atresia treated over the last 22 years","volume":"222","author":"Lacher","year":"2010","journal-title":"Klin Padiatr."},{"key":"B7","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1136\/archdischild-2012-301730","article-title":"Long-term outcome of children with oesophageal atresia type III","volume":"97","author":"Legrand","year":"2012","journal-title":"Arch Dis Child."},{"key":"B8","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3345\/kjp.2010.53.6.705","article-title":"An 18-year experience of tracheoesophageal fistula and esophageal atresia","volume":"53","author":"Seo","year":"2010","journal-title":"Korean J Pediatr."},{"key":"B9","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jpeds.2021.10.012","article-title":"Feeding and growth outcomes in infants with type C esophageal atresia who undergo early primary repair","volume":"241","author":"Harrington","year":"2021","journal-title":"J Pediatr"},{"key":"B10","doi-asserted-by":"publisher","first-page":"F417","DOI":"10.1136\/archdischild-2016-311598","article-title":"Longitudinal evaluation of growth in oesophageal atresia patients up to 12 years","volume":"102","author":"Vergouwe","year":"2017","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"B11","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1097\/MPG.0000000000001436","article-title":"Prevalence of malnutrition and feeding difficulties in children with esophageal atresia","volume":"64","author":"Menzies","year":"2017","journal-title":"J Pediatr Gastroenterol Nutr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1055\/s-0035-1569466","article-title":"National esophageal atresia register","volume":"25","author":"Sfeir","year":"2015","journal-title":"Eur J Pediatr Surg."},{"key":"B13","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1097\/00000658-194701000-00002","article-title":"Esophageal atresia and tracheo-esophageal fistula","volume":"125","author":"Ladd","year":"1947","journal-title":"Ann Surg."},{"key":"B14","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1542\/pir.2016-0050","article-title":"CHARGE syndrome","volume":"38","author":"Hudson","year":"2017","journal-title":"Pediatr Rev."},{"key":"B15","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1750-1172-6-56","article-title":"VACTERL\/VATER association","volume":"6","author":"Solomon","year":"2011","journal-title":"Orphanet J Rare Dis."},{"key":"B16","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2431-13-59","article-title":"A systematic review and meta-analysis to revise the Fenton growth chart for preterm infants","volume":"13","author":"Fenton","year":"2013","journal-title":"BMC Pediatr."},{"key":"B17","unstructured":"De nouvelles courbes de croissance de r\u00e9f\u00e9rence fran\u00e7aises. Salle de presse2018"},{"key":"B18","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.3148\/71.1.2010.54","article-title":"Promoting optimal monitoring of child growth in Canada: using the new WHO growth charts","volume":"71","year":"2010","journal-title":"Can J Diet Pract Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.1016\/j.jpedsurg.2020.02.018","article-title":"The burden of esophageal dilatations following repair of esophageal atresia","volume":"55","author":"Campos","year":"2020","journal-title":"J Pediatr Surg."},{"key":"B20","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1007\/s00431-020-03733-1","article-title":"Risk factors for digestive morbidities after esophageal atresia repair","volume":"180","author":"Lu","year":"2021","journal-title":"Eur J Pediatr."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1016\/j.jpedsurg.2017.04.021","article-title":"Long-term outcomes of oesophageal atresia without or with proximal tracheooesophageal fistula - gross types A and B","volume":"52","author":"Koivusalo","year":"2017","journal-title":"J Pediatr Surg."},{"key":"B22","doi-asserted-by":"publisher","first-page":"2242","DOI":"10.1016\/j.jpedsurg.2019.06.017","article-title":"Surgical treatment and major complications within the first year of life in newborns with long-gap esophageal atresia gross type A and B - a systematic review","volume":"54","author":"Stadil","year":"2019","journal-title":"J Pediatr Surg."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v045.i03","article-title":"mice: multivariate imputation by chained equations in R","volume":"45","author":"Van Buuren","year":"2011","journal-title":"J Stat Softw"},{"key":"B24","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1016\/S0022-3468(03)00110-6","article-title":"Long-term analysis of children with esophageal atresia and tracheoesophageal fistula","volume":"38","author":"Little","year":"2003","journal-title":"J Pediatr Surg."},{"key":"B25","doi-asserted-by":"publisher","first-page":"F428","DOI":"10.1136\/adc.2001.004044","article-title":"Postnatal growth retardation: a universal problem in preterm infants","volume":"89","author":"Cooke","year":"2004","journal-title":"Arch Dis Child Fetal Neonatal Ed."},{"key":"B26","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.arcped.2010.12.006","volume":"18","author":"Lapillonne","year":"2011","journal-title":"Arch Pediatr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/ped.13939","article-title":"Risk factors for absence of catch-up growth in small for gestational age very low-birthweight infants","volume":"61","author":"Arai","year":"2019","journal-title":"Pediatr Int"},{"key":"B28","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1203\/00006450-199508000-00022","article-title":"children born small for gestational age: do they catch up?","volume":"38","author":"Hokken-Koelega","year":"1995","journal-title":"Pediatr Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.perped.2019.04.002","volume":"2","year":"2019","journal-title":"Perfect En P\u00e9diatrie"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.969617\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T13:45:56Z","timestamp":1659620756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.969617\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,4]]},"references-count":29,"alternative-id":["10.3389\/fped.2022.969617"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.969617","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,4]]},"article-number":"969617"}}