{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:16Z","timestamp":1753891876194,"version":"3.41.2"},"reference-count":9,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T00:00:00Z","timestamp":1663718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Chronic neutrophilic leukemia (CNL) is a rare <jats:italic>BCR-ABL<\/jats:italic> negative myeloproliferative neoplasm that usually affects older adults with a poor prognosis. Leukemia cutis is an extramedullary manifestation of leukemia and may be misdiagnosed by dermatologists. Here, we describe a case of CNL in a 6-year-old Chinese girl with leukemia cutis as the first manifestation. Her skin rashes failed to attract the attention of dermatologists in early stages. The diagnosis was confirmed by peripheral smear, bone marrow studies, genomic analysis and skin biopsy.<\/jats:p>","DOI":"10.3389\/fped.2022.972224","type":"journal-article","created":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T07:47:16Z","timestamp":1663746436000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl"],"prefix":"10.3389","volume":"10","author":[{"given":"Ya Bin","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Feng","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi Gang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui Hui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-018-0049-8","article-title":"Chronic neutrophilic leukemia: new science and new diagnostic criteria.","volume":"8","author":"Szuber","year":"2018","journal-title":"Blood Cancer J."},{"key":"B2","doi-asserted-by":"publisher","first-page":"853","DOI":"10.6004\/jadpro.2019.10.8.6","article-title":"Chronic neutrophilic leukemia: a case report of a rare myeloproliferative neoplasm with a CSF3R mutation.","volume":"10","author":"Coombs","year":"2019","journal-title":"J Adv Pract Oncol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"673","DOI":"10.5021\/ad.2019.31.6.673","article-title":"Leukemia cutis in chronic neutrophilic leukemia associated with colony stimulating factor 3 receptor mutation: clinical severity paralleled with hematologic abnormality.","volume":"31","author":"Kwon","year":"2019","journal-title":"Ann Dermatol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2391","DOI":"10.1182\/blood-2016-03-643544","article-title":"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.","volume":"127","author":"Arber","year":"2016","journal-title":"Blood."},{"key":"B5","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1610-0387.2011.07842.x","article-title":"Leukemia cutis - epidemiology, clinical presentation, and differential diagnoses.","volume":"10","author":"Wagner","year":"2012","journal-title":"J Dtsch Dermatol Ges."},{"key":"B6","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/0190-9622(93)70178-v","article-title":"Neutrophilic dermatosis associated with chronic neutrophilic leukemia.","volume":"29","author":"Castanet","year":"1993","journal-title":"J Am Acad Dermatol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/j.blre.2017.07.003","article-title":"The skin as a window to the blood: cutaneous manifestations of myeloid malignancies.","volume":"31","author":"Li","year":"2017","journal-title":"Blood Rev."},{"key":"B8","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/cup.13925","article-title":"Case and review: cutaneous involvement by chronic neutrophilic leukemia vs Sweet syndrome- a diagnostic dilemma.","volume":"48","author":"Hobbs","year":"2021","journal-title":"J Cutan Pathol."},{"key":"B9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1067\/mjd.2001.103996","article-title":"Leukemia cutis in a patient with chronic neutrophilic leukemia.","volume":"44","author":"Willard","year":"2001","journal-title":"J Am Acad Dermatol."}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.972224\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,21]],"date-time":"2022-09-21T07:47:19Z","timestamp":1663746439000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2022.972224\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,21]]},"references-count":9,"alternative-id":["10.3389\/fped.2022.972224"],"URL":"https:\/\/doi.org\/10.3389\/fped.2022.972224","relation":{},"ISSN":["2296-2360"],"issn-type":[{"type":"electronic","value":"2296-2360"}],"subject":[],"published":{"date-parts":[[2022,9,21]]},"article-number":"972224"}}