{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:23:45Z","timestamp":1790641425668,"version":"4.1.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T00:00:00Z","timestamp":1670198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:p>Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE<jats:sup>+<\/jats:sup> long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE<jats:sup>+<\/jats:sup> LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE<jats:sup>+<\/jats:sup> PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE<jats:sup>+<\/jats:sup> LLPCs.<\/jats:p>","DOI":"10.3389\/fped.2022.979012","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T06:47:10Z","timestamp":1670222830000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["IgE-expressing long-lived plasma cells in persistent sensitization"],"prefix":"10.3389","volume":"10","author":[{"given":"Shiqiu","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.jaci.2016.02.005","article-title":"Prevention of food allergy","volume":"137","author":"Toit","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B2","first-page":"1","article-title":"Trends in allergic conditions among children: United States, 1997\u20132011","volume":"121","author":"Jackson","year":"2013","journal-title":"NCHS Data Brief"},{"key":"B3","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.iac.2021.07.012","article-title":"Diagnosis and management of food allergy","volume":"41","author":"Oriel","year":"2021","journal-title":"Immunol Allergy Clin North Am"},{"key":"B4","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.envres.2017.06.009","article-title":"Nasal epithelium injury by chlorination products and other stressors predicts persistent sensitization to aeroallergens in young schoolchildren","volume":"158","author":"Bernard","year":"2017","journal-title":"Environ Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1111\/pai.13592","article-title":"Childhood food allergy and food allergen sensitisation are associated with adult airways disease: a birth cohort study","volume":"32","author":"Fong","year":"2021","journal-title":"Pediatr Allergy Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1007\/s11882-020-0898-7","article-title":"Epidemiology and burden of food allergy","volume":"20","author":"Warren","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1111\/all.13124","article-title":"Allergen immunotherapy for IgE-mediated food allergy: a systematic review and meta- analysis","volume":"72","author":"Nurmatov","year":"2017","journal-title":"Allergy"},{"key":"B8","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1111\/imr.13015","article-title":"On the road to eliminating long-lived plasma cells\u2014\u201care we there yet?\u201d","volume":"303","author":"Markmann","year":"2021","journal-title":"Immunol Rev"},{"key":"B9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/s40478-017-0487-8","article-title":"The chronically inflamed central nervous system provides niches for long-lived plasma cells","volume":"5","author":"Pollok","year":"2017","journal-title":"Acta Neuropathol Commun"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.4049\/jimmunol.117.4.1139","article-title":"The metabolism of IgE. 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