{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T21:25:46Z","timestamp":1779917146105,"version":"3.53.1"},"reference-count":21,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to determine the influence of fluid overload on bronchopulmonary dysplasia (BPD) in very low-birth-weight infants (VLBWI) within 1 week after birth.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective case control study conducted in the Jingzhou Central Hospital. The clinical data of VLBWI (with a birth weight [BW] &amp;lt; 1,500 g and 26 weeks \u2264 gestational age [GA] &amp;lt; 32 weeks) who were admitted to the neonatal intensive care unit of this hospital from January 2016 to December 2021 were analyzed retrospectively. A total of 157 cases were enrolled and divided into a BPD group (<jats:italic>n<\/jats:italic> = 60) and a non-BPD group (<jats:italic>n<\/jats:italic> = 97) according to whether BPD was present. The general condition, fluid intake, and fluid overload of the two groups of neonates within 1 week after birth were compared. The logistic regression was used to assess the association between infant characteristics and BPD. The ROC curve was used to assess how well the 7 day cumulative fluid overload predicted BPD, and to identify an optimal cut off for prediction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The comparison of the patients' general condition revealed that the neonates in the BPD group had a younger GA, lower BW, lower 5-min Apgar score, longer duration of invasive mechanical ventilation, and higher incidence of intrauterine infections and administration of surfactants (<jats:italic>P<\/jats:italic> &amp;lt; 0.05). The differences in the other indicators were not statistically significant between the two groups. The logistic regression analysis revealed that a younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were the risk factors for the development of BPD. A ROC curve was plotted with the 7-day cumulative fluid overload as the test variable and BPD as the status variable. The area under the curve was 0.75 (95% confidence interval: 0.664\u20130.826, <jats:italic>P<\/jats:italic> = 0.042), with a sensitivity of 76.7% and a specificity of 70.1%, corresponding to a 7-day cumulative fluid overload of 36.2%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A younger GA, the presence of intrauterine infection, and a 7-day cumulative fluid overload were risk factors for the development of BPD. A 7 day cumulative fluid overload threshold of 36.2% best predicted the development of BPD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.980179","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:15:18Z","timestamp":1665468918000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Influence of early fluid overload on bronchopulmonary dysplasia in very low-birth-weight infants"],"prefix":"10.3389","volume":"10","author":[{"given":"Yu-Jie","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Fang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Hong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qian","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12967-018-1417-7","article-title":"Bronchopulmonary dysplasia: clinical aspects and preventive and therapeutic strategies","volume":"16","author":"Principi","year":"2018","journal-title":"J Transl Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.3390\/jcm9051539","article-title":"Present and future of bronchopulmonary dysplasia","volume":"9","author":"Bonadies","year":"2020","journal-title":"J Clin Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1007\/s00431-020-03654-z","article-title":"Early fluid overload is associated with mortality and prolonged mechanical ventilation in extremely low birth weight infants","volume":"179","author":"Matsushita","year":"2020","journal-title":"Eur J Pediatr."},{"key":"B4","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1016\/j.jpeds.2005.06.039","article-title":"Association between fluid intake and weight loss during the first ten days of life and risk of bronchopulmonary dysplasia in extremely low birth weight infants","volume":"147","author":"Oh","year":"2005","journal-title":"J Pediatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.3233\/NPM-190267","article-title":"Low caloric intake and high fluid intake during the first week of life are associated with the severity of bronchopulmonary dysplasia in extremely low birth weight infants","volume":"13","author":"Al-Jebawi","year":"2020","journal-title":"J Neonatal Perinatal Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1038\/s41390-021-01485-8","article-title":"Sant'Anna G, Beltempo M. 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