{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:11:19Z","timestamp":1753891879134,"version":"3.41.2"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009991","name":"Department of Finance of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009991","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the effect of systemic corticosteroids (CSs) on ocular hypertension (OHT) and to evaluate the management of OHT in children with non-Hodgkin lymphoma (NHL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records of children with NHL treated in our institution between October 2016 and October 2019 were reviewed. The enrolled patients were divided into the mature B-cell lymphoma (MBL) group and lymphoblastic lymphoma (LBL) group based on pathology. Data on routine ophthalmic examinations and management of OHT were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 54 recruited patients, 38 patients (70.4%) had LBL, and 16 (29.6%) had MBL. Thirty-one patients (57.4%) developed OHT, 24 patients (77.4%) in the LBL group, and 7 (22.6%) in the MBL group. Twelve patients (38.7%) were identified as high responders (10 with LBL and 2 with MBL). Symptomatic patients had a higher mean peak IOP than asymptomatic patients (<jats:italic>p<\/jats:italic>=0.006). A total of 74.2% of OHT was controlled with antiglaucoma medications (100% in the MBL group <jats:italic>vs<\/jats:italic>. 66.7% in the LBL group, significant variation, <jats:italic>p<\/jats:italic> &amp;lt; 0.001). In total, 8 patients (25.8%) underwent tapering of the CSs dose. The duration of OHT was shorter in the MBL group than in the LBL group (<jats:italic>p<\/jats:italic> = 0.003). No patients were found to have glaucomatous damage or cataracts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients receiving systemic CSs had a higher risk of developing OHT, but the pattern of CSs administration might be a critical factor in the risk and severity of OHT. Tapering of CSs dose should be considered the first line for the management of OHT during high-dose CSs therapy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.982224","type":"journal-article","created":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T06:31:04Z","timestamp":1660285864000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation and management of systemic corticosteroids-induced ocular hypertension in children with non-Hodgkin lymphoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Yitian","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YuTong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhihua","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianmei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/bjh.15764","article-title":"Childhood, adolescent and young adult non-Hodgkin lymphoma: current perspectives","volume":"185","author":"Cairo","year":"2019","journal-title":"Br J Haematol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"67","DOI":"10.5005\/jp-journals-10028-1226","article-title":"Steroid-induced Glaucoma: an Avoidable Irreversible Blindness","volume":"11","author":"Phulke","year":"2017","journal-title":"J Curr Glaucoma Pract."},{"key":"B3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1097\/IOP.0000000000001320","article-title":"Effect of topical periocular steroid use on intraocular pressure: a retrospective analysis","volume":"35","author":"Maeng","year":"2019","journal-title":"Ophthalmic Plast Reconstr Surg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1438","DOI":"10.1097\/IAE.0000000000003080","article-title":"Long-term incidence and risk factors of ocular hypertension following dexamethasone-implant injections: the SAFODEX-2 study","volume":"41","author":"Rezkallah","year":"2021","journal-title":"Retina."},{"key":"B5","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/j.1365-2133.1976.tb00830.x","article-title":"Glaucoma following the application of corticosteroid to the skin of the eyelids","volume":"95","author":"Cubey","year":"1976","journal-title":"Br J Dermatol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/0002-9394(64)92500-0","article-title":"Topical corticosteroids and heredity in primary open-angle glaucoma","volume":"57","author":"Becker","year":"1964","journal-title":"Am J Ophthalmol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.2147\/OPTH.S36261","article-title":"Severe ocular hypertension secondary to systemic corticosteroid treatment in a child with nephrotic syndrome","volume":"6","author":"Brito","year":"2012","journal-title":"Clin Ophthalmol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1136\/bjo.64.6.430","article-title":"Intraocular pressure response to corticosteroids in children","volume":"64","author":"Biedner","year":"1980","journal-title":"Br J Ophthalmol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e27977","DOI":"10.1002\/pbc.27977","article-title":"Corticosteroid-induced glaucoma in pediatric patients with hematological malignancies","volume":"66","author":"Sugiyama","year":"2019","journal-title":"Pediatr Blood Cancer."},{"key":"B10","doi-asserted-by":"publisher","first-page":"2083","DOI":"10.1002\/pbc.25070","article-title":"Steroid-induced ocular hypertensive response in children and adolescents with acute lymphoblastic leukemia and non-Hodgkin lymphoma","volume":"61","author":"de Queiroz Mendonca","year":"2014","journal-title":"Pediatr Blood Cancer."},{"key":"B11","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1111\/j.1755-3768.1972.tb06606.x","article-title":"Systemic steroids and ocular fluid dynamics. 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