{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T01:44:21Z","timestamp":1783734261680,"version":"3.55.0"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T00:00:00Z","timestamp":1666310400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022NSFSC0743"],"award-info":[{"award-number":["2022NSFSC0743"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze obstructive sleep apnea (OSA)-related quality of life (QoL), the statuses of depression and anxiety, and to reveal the correlation between OSA-related QoL and two mental statuses in Chinese adolescent patients with cleft palate (CP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Obstructive Sleep Apnea Questionaire-18 (OSA-18), the Generalized Anxiety Disorder Scale (GAD-7) and the Patient Health Questionnaire-9 (PHQ-9) were applied to assess OSA-related QoL and the statuses of anxiety and depression in Chinese adolescent patients with CP, respectively. Non-CP adolescents were also included in the control group. OSA-related QoL and the two mental statuses were compared between the study and control groups. The correlation between the OSA-related QoL and two mental statuses was estimated in Chinese adolescent patients with CP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8.7% patients showed a moderate or high impact of OSA on QoL, while all the adolescents from the control group showed little impact. The mean total OSA-18 score of the study group (36.261\u2009\u00b1\u200913.500) was significantly higher than the control (28.435\u2009\u00b1\u20098.934). The mean PHQ-9 scores of the study group and the control group were statistically different (3.957 vs. 2.113). The GAD-7 score in the study group was slightly higher than the control group (3.043 vs. 2.194), while the proportion of moderate-severe anxiety in the study group was relatively larger than that in the control group (6.5% vs. 1.6%). Moreover, there was a positive correlation between the OSA-related QoL and the statuses of anxiety and depression respectively, and the differences in GAD-7 and PHQ-9 scores between the moderate or high impact group and the little impact group were statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chinese adolescents with CP reported a rate of moderate or high impact of OSA on QoL of 8.7%, which was significantly higher than adolescents without CP. The OSA-related QoL was worse and depression was severer in Chinese CP adolescents than in the control, while anxiety and depression in Chinese CP adolescents were associated with OSA-related QoL.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.985375","type":"journal-article","created":{"date-parts":[[2022,10,21]],"date-time":"2022-10-21T06:14:15Z","timestamp":1666332855000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The correlation between OSA-related quality of life and two mental statuses in adolescent Chinese patients with cleft palate: A comprehensive study"],"prefix":"10.3389","volume":"10","author":[{"given":"Yuan","family":"Zong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojun","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caixia","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanyao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,10,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"568e","DOI":"10.1097\/prs.0000000000008334","article-title":"Global burden of orofacial clefts and the world surgical workforce","volume":"148","author":"Massenburg","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"10556656211068306","DOI":"10.1177\/10556656211068306","article-title":"Prevalence and risk factors for obstructive sleep apnea syndrome among children and adolescents with cleft lip and palate: a survey study in Hong Kong","author":"Ho","year":"2021","journal-title":"Cleft Palate Craniofac J"},{"key":"B3","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1597\/1545-1569_2003_040_0498_caotpa_2.0.co_2","article-title":"Cephalometric assessment of the posterior airway space in patients with cleft palate after palatoplasty","volume":"40","author":"Rose","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"key":"B4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.2165\/00151829-200605040-00002","article-title":"Improving health-related quality of life in patients with obstructive sleep apnea: what are the available options?","volume":"5","author":"Shah","year":"2006","journal-title":"Treat Respir Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-022-02589-z","article-title":"The association between sleep architecture, quality of life, and hypertension in patients with obstructive sleep apnea","author":"Chen","year":"2022","journal-title":"Sleep Breath"},{"key":"B6","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/15402002.2018.1545649","article-title":"Association of anxiety and depression in obstructive sleep apnea patients: a systematic review and meta-analysis","volume":"18","author":"Garbarino","year":"2020","journal-title":"Behav Sleep Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.jpsychores.2007.10.016","article-title":"A bidirectional relationship between anxiety and depression, and insomnia? 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