{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:57:02Z","timestamp":1787673422716,"version":"build-2736575974"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>The accurate assessment of the stages of hepatic fibrosis in children with biliary atresia (BA) before performing Kasai portoenterostomy (KPE) is of utmost importance. Some studies demonstrated that ultrasound elastography can be used to assess the stages of hepatic fibrosis by detecting liver stiffness. Therefore, the aim of this work was to explore the usefulness of sound touch elastography (STE) for preoperatively assessing liver cirrhosis in infants with BA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 189 children from the Hunan Children\u2019s Hospital with highly suspected BA were selected for this study, and their preoperative liver STE values and related clinical data were collected. The pathological results of the liver stages were considered as the gold standard. Spearman correlation was used to analyze the correlation between each parameter and the stage of hepatic fibrosis, and the receiver operator characteristic (ROC) curve was used to analyze the diagnostic performance for cirrhosis of each parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the selected 189 patients with suspected BA, 159 were included in this study and were composed of 3 at hepatic fibrosis stage F1, 45 at stage F2, 41 at stage F3, and 70 at stage F4, while no patients at stage F0 were present. Spearman correlation analysis showed that the liver STE value had the highest correlation with the stage of hepatic fibrosis, with a correlation coefficient of 0.813 (<jats:italic>P<\/jats:italic> &amp;lt; 0.001). The liver STE value had the highest diagnostic performance for hepatic cirrhosis compared to other biomarkers of serum fibrosis; the area under the ROC curve was 0.899 when the best cut-off value was 14.57 kPa. The sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy were 78.6, 84.3, 79.7, 83.3, and 81.8%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The liver STE value has a high correlation with the stage of hepatic fibrosis in children with BA. STE has a good diagnostic performance in evaluating cirrhosis before KPE in children with BA.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2022.989293","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T05:41:21Z","timestamp":1664430081000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Sound touch elastography for assessing cirrhosis preoperatively in infants with biliary atresia: Comparison with serum fibrosis biomarkers"],"prefix":"10.3389","volume":"10","author":[{"given":"Xingxing","family":"Duan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wengang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.874809","article-title":"The value of hepatic scintigraphy in the diagnosis of biliary atresia.","volume":"10","author":"Chan","year":"2022","journal-title":"Front Pediatr."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2144\/fsoa-2019-0153","article-title":"Biliary atresia: pathology, etiology and pathogenesis.","volume":"6","author":"Vij","year":"2020","journal-title":"Future Sci OA."},{"key":"B3","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11040999","article-title":"Biliary atresia in 2021: epidemiology, screening and public policy.","volume":"11","author":"Schreiber","year":"2022","journal-title":"J Clin Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/S0140-6736(09)60946-6","article-title":"Biliary atresia.","volume":"374","author":"Hartley","year":"2009","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1007\/s00383-017-4173-5","article-title":"Liver transplantation for biliary atresia: a systematic review.","volume":"33","author":"Kasahara","year":"2017","journal-title":"Pediatr Surg Int."},{"key":"B6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.dld.2015.11.021","article-title":"Comparison of liver transplantation outcomes in biliary atresia patients with and without prior portoenterostomy: a meta-analysis.","volume":"48","author":"Wang","year":"2016","journal-title":"Dig Liver Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1007\/s00247-020-04959-9","article-title":"Diagnostic accuracy of two-dimensional shear wave elastography in detecting hepatic fibrosis in children with autoimmune hepatitis, biliary atresia and other chronic liver diseases.","volume":"51","author":"Galina","year":"2021","journal-title":"Pediatr Radiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3348\/kjr.2020.0055","article-title":"Diffusion-weighted imaging for differentiation of biliary atresia and grading of hepatic fibrosis in infants with cholestasis.","volume":"22","author":"Kim","year":"2021","journal-title":"Korean J Radiol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"853","DOI":"10.7863\/ultra.33.5.853","article-title":"Transient elastography and sonography for prediction of liver fibrosis in infants with biliary atresia.","volume":"33","author":"Shin","year":"2014","journal-title":"JUM."},{"key":"B10","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1053\/j.sempedsurg.2017.09.003","article-title":"Long-term outlook in biliary atresia.","volume":"26","author":"Kelay","year":"2017","journal-title":"Semin Pediatr Surg."},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9036362","article-title":"Does supersonic shear wave elastography help differentiate biliary atresia from other causes of cholestatic hepatitis in infants less than 90 days old? 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