{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:06:35Z","timestamp":1791068795451,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T00:00:00Z","timestamp":1678665600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Pediatr."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Post-operative systemic inflammation response syndrome (SIRS) is an event that results from surgical trauma, white blood cells contact activation, and intra-surgical bacterial translocation, which is difficult to distinguish from sepsis. Presepsin is a novel biomarker that is increased since the early stages of bacterial infection and can be used to confirm the diagnosis of post-operative infectious complications. This study aimed to investigate the diagnostic performance of presepsin for post-operative infectious complications compared to other well-known biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This cross-sectional study included 100 post-operative patients admitted to Cipto Mangunkusumo National Hospital and Bunda Hospital in Jakarta, Indonesia. The objective was to identify the optimal cutoff and trend of plasma presepsin concentration on the first and third day after surgery and to compare them with other biomarkers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Result<\/jats:title><jats:p>Plasma presepsin level was higher in the infection group compared to the non-infection group (median 806.5\u2005pg\/ml vs. 717\u2005pg\/ml and 980\u2005pg\/ml vs. 516\u2005pg\/ml on the first and third day, respectively). Presepsin levels tended to increase on the third post-operative day (median\u2009+\u2009252\u2005pg\/ml) in children with infection. The opposite trend was observed in the non-infection group from the first to the third day (median -222.5\u2005pg\/ml). Presepsin delta, a three-day difference between the first and third post-operative day, had the best diagnostic performance compared to other biomarkers (Area Under the Curve 0.825). The optimal cutoff for presepsin delta to diagnose post-operative infection was +90.5\u2005pg\/ml.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serial assessments of presepsin levels on the first and third days post-surgery and their trends are helpful diagnostic markers for clinicians to detect post-operative infectious complications in children.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fped.2023.1036993","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:11:20Z","timestamp":1678684280000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Presepsin as a promising biomarker for early detection of post-operative infection in children"],"prefix":"10.3389","volume":"11","author":[{"given":"Niken Wahyu","family":"Puspaningtyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulya Rahma","family":"Karyanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiara Nien","family":"Paramita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikari Ambara","family":"Sjakti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina Dwi","family":"Putri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bambang","family":"Tridjaja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piprim Basarah","family":"Yanuarso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kshetra","family":"Rinaldhy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Yani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramita","family":"Gayatri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,3,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1213\/ANE.0000000000005175","article-title":"Systemic inflammatory response syndrome after surgery: mechanisms and protection","volume":"131","author":"Margraf","year":"2020","journal-title":"Anesth Analg"},{"key":"B2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/adc.2010.183111","article-title":"Risk score to stratify children with suspected serious bacterial infection: observational cohort study","volume":"96","author":"Brent","year":"2011","journal-title":"Arch Dis Child"},{"key":"B3","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1586\/eri.10.154","article-title":"Biomarkers for pediatric sepsis and septic shock","volume":"9","author":"Standage","year":"2011","journal-title":"Expert Rev Anti Infect Ther"},{"key":"B4","doi-asserted-by":"publisher","first-page":"547818","DOI":"10.1155\/2014\/547818","article-title":"Biomarkers for sepsis","volume":"2014","author":"Henriquez-Camacho","year":"2014","journal-title":"Biomed Res Int"},{"key":"B5","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1016\/j.annemergmed.2012.05.027","article-title":"Comparison of the test characteristics of procalcitonin to C-reactive protein and leukocytosis for the detection of serious bacterial infections in children presenting with fever without source: a systematic review and meta-analysis","volume":"60","author":"Yo","year":"2012","journal-title":"Ann Emerg Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.5847\/wjem.j.issn.1920-8642.2014.01.002","article-title":"Presepsin as a novel sepsis biomarker","volume":"5","author":"Zou","year":"2014","journal-title":"World J Emerg Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3109\/14767058.2011.601923","article-title":"Soluble CD14 subtype presepsin (sCD14-ST) and lipopolysaccharide binding protein (LBP) in neonatal sepsis: new clinical and analytical perspectives for two old biomarkers","volume":"24","author":"Mussap","year":"2011","journal-title":"J Matern Neonatal Med"},{"key":"B8","first-page":"e15019","article-title":"Presepsin as a diagnostic and prognostic biomarker in sepsis","volume":"13","author":"Velissaris","year":"2021","journal-title":"Cureus"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1016\/j.cca.2011.07.024","article-title":"Development of a point-of-care assay system for measurement of presepsin (sCD14-ST)","volume":"412","author":"Okamura","year":"2011","journal-title":"Clin Chim Acta"},{"key":"B10","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1186\/s12879-019-4397-1","article-title":"Presepsin as a diagnostic marker of sepsis in children and adolescents: a systemic review and meta-analysis","volume":"19","author":"Yoon","year":"2019","journal-title":"BMC Infect Dis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s13613-015-0089-1","article-title":"The accuracy of presepsin for the diagnosis of sepsis from SIRS: a systematic review and meta-analysis","volume":"5","author":"Zheng","year":"2015","journal-title":"Ann Intensive Care"},{"key":"B12","doi-asserted-by":"publisher","first-page":"e0133057","DOI":"10.1371\/journal.pone.0133057","article-title":"Accuracy of presepsin in sepsis diagnosis:\u00a0a\u00a0systematic review and meta-analysis","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"},{"key":"B13","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jbi.2014.02.013","article-title":"Sample size estimation in diagnostic test studies of biomedical informatics","volume":"48","author":"Hajian-Tilaki","year":"2014","journal-title":"J Biomed Inform"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1007\/s00246-014-0953-z","article-title":"Health care-associated infections in children after cardiac surgery","volume":"35","author":"Turcotte","year":"2014","journal-title":"Pediatr Cardiol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/PCC.0000000000001445","article-title":"Risk factors for healthcare-associated infections after pediatric cardiac surgery","volume":"19","author":"Hatachi","year":"2018","journal-title":"Pediatr Crit Care Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e0225607","DOI":"10.1371\/journal.pone.0225607","article-title":"Preoperative and operation-related risk factors for postoperative nosocomial infections in pediatric patients: a retrospective cohort study","volume":"14","author":"Li","year":"2019","journal-title":"PLoS One"},{"key":"B17","year":""},{"key":"B18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cca.2015.06.026","article-title":"Presepsin (sCD14-ST), an innate immune response marker in sepsis","volume":"450","author":"Chenevier-Gobeaux","year":"2015","journal-title":"Clin Chim Acta"},{"key":"B19","doi-asserted-by":"publisher","first-page":"768","DOI":"10.23736\/S0375-9393.20.14169-5","article-title":"Presepsin as a biomarker in perioperative medicine","volume":"86","author":"Handke","year":"2020","journal-title":"Minerva Anestesiol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.biopha.2018.12.124","article-title":"Presepsin: a promising biomarker for the detection of bacterial infections","volume":"111","author":"Memar","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"B21","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1097\/BRS.0000000000002376","article-title":"Postoperative changes in presepsin level and values predictive of surgical site infection after spinal surgery: a single-center, prospective observational study","volume":"43","author":"Koakutsu","year":"2018","journal-title":"Spine (Phila Pa 1976)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s10388-020-00736-7","article-title":"The perioperative presepsin as an accurate diagnostic marker of postoperative infectious complications after esophagectomy: a prospective cohort study","volume":"17","author":"Takeuchi","year":"2020","journal-title":"Esophagus"},{"key":"B23","doi-asserted-by":"publisher","first-page":"30","DOI":"10.5114\/kitp.2015.50565","article-title":"Prognostic value of sCD14-ST (presepsin) in cardiac surgery","volume":"12","author":"Popov","year":"2015","journal-title":"Kardiochirurgia I Torakochirurgia Pol=Polish J Cardio-Thoracic Surg"},{"key":"B24","doi-asserted-by":"publisher","first-page":"P194","DOI":"10.1186\/cc6415","article-title":"Early elevation of plasma soluble CD14 subtype, a novel biomarker for sepsis, in a rabbit cecal ligation and puncture model","volume":"12","author":"Nakamura","year":"2008","journal-title":"Crit Care"},{"key":"B25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1097\/SHK.0000000000001479","article-title":"The prognostic value of presepsin for sepsis in abdominal surgery: a prospective study","volume":"54","author":"B\u00f6sch","year":"2020","journal-title":"Shock"},{"key":"B26","doi-asserted-by":"publisher","first-page":"215","DOI":"10.5114\/ait.2021.108159","article-title":"Perioperative presepsin as a potential early predictor for postoperative infectious complications in cardiac surgery","volume":"53","author":"Suzuki","year":"2021","journal-title":"Anaesthesiol Intensive Ther"},{"key":"B27","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1002\/jhbp.802","article-title":"Diagnostic potential of presepsin in bacterial infection following hepato-biliary-pancreatic surgery: a prospective observational study","volume":"27","author":"Yao","year":"2020","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"B28","doi-asserted-by":"publisher","first-page":"4301","DOI":"10.1111\/jocs.15952","article-title":"C-reactive protein and procalcitonin after congenital heart surgery utilizing cardiopulmonary bypass: when should we be worried?","volume":"36","author":"Farias","year":"2021","journal-title":"J Card Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1001\/jamainternmed.2013.9763","article-title":"Health care-associated infections: a meta-analysis of costs and financial impact on the US health care system","volume":"173","author":"Zimlichman","year":"2013","journal-title":"JAMA Intern Med"}],"container-title":["Frontiers in Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2023.1036993\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T05:11:23Z","timestamp":1678684283000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fped.2023.1036993\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,13]]},"references-count":29,"alternative-id":["10.3389\/fped.2023.1036993"],"URL":"https:\/\/doi.org\/10.3389\/fped.2023.1036993","relation":{},"ISSN":["2296-2360"],"issn-type":[{"value":"2296-2360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,13]]},"article-number":"1036993"}}